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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GDF10, PHIP (from a repository: Thu Jul 25 05:39:14 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins7 (26.92 %)
The number (and %) of the tumor suppressors3 (11.54 %)
Total number of binary PPIs (saturation %)74 (22.77 %)
The number (and %) of affected PPIs24 (32.43 %)
The number of possible different fusions6
PPI diameter2
PPI radiusinf
The average degree of PPI4.923
Assortativity coefficient-0.2170
The network average Clustering coefficient0.505
The number (and %) of a zero Clustering coefficients6 (23.08 %)
The number (and %) of a zero Betweenness Centrality10 (38.46 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GDF10,PHIP All fusions
Proteins found in more fusions DDB1 (see 4 fusions); CUL7 (see 2 fusions); MPHOSPH8 (see 5 fusions); CUL3 (see 1 fusions); CUL4A (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GDF10parental protein100TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
2 PHIPparental protein230.158338.733DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
E7 (PF00527, IPR000148): E7 protein, Early protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
3 CENPAinteractor50.6672.000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
4 CNTROBinteractor21.0000DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
FadA (PF09403, IPR018543): Adhesion protein FadA
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
5 CUL3protein found in more fusions90.57110.233Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
6 CUL4Aprotein found in more fusions100.52812.567Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
7 CUL4Boncoprotein70.7622.733Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
8 CUL7protein found in more fusions70.6004.833ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
9 DCUN1D1interactor51.0000Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
10 DDB1protein found in more fusions120.45523.233CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
11 EGR1suppressor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3432 (PF11914, IPR021839): Domain of unknown function (DUF3432)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
12 HDAC11interactor30.6671.000Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
13 HIST1H3Ainteractor70.4677.167Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
14 IFI16suppressor40.5002.333HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
15 KRASoncoprotein200Ras (PF00071, IPR001806, SM00173): Ras family
16 MPHOSPH8protein found in more fusions40.6670.667Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
YqzE (PF14038, IPR025622): YqzE-like protein
17 OBSL1interactor50.8330.667BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
18 ORC1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
BAH (PF01426, IPR001025, SM00439): BAH domain
Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
19 RNF2interactor40.6671.000zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
20 RPL10suppressor70.33312.833Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
21 SIRT7interactor60.6004.000DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
22 SPICE1interactor100SPICE (PF15678, IPR031387): Centriole duplication and mitotic chromosome congression
ANXA2R (PF15721, IPR031449): Annexin-2 receptor
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
23 STMN4interactor100Stathmin (PF00836, IPR000956): Stathmin family
Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
DUF3844 (PF12955, IPR024382): Domain of unknown function (DUF3844)
24 TMPOinteractor40.6672.000LEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha
25 TUBB3interactor21.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
26 UBXN7interactor51.0000UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain

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