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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)65
The number (and %) of the onco-proteins27 (41.54 %)
The number (and %) of the tumor suppressors14 (21.54 %)
Total number of binary PPIs (saturation %)303 (14.57 %)
The number (and %) of affected PPIs63 (20.79 %)
The number of possible different fusions20
PPI diameter4
PPI radius2
The average degree of PPI7.785
Assortativity coefficient-0.2009
The network average Clustering coefficient0.508
The number (and %) of a zero Clustering coefficients7 (10.77 %)
The number (and %) of a zero Betweenness Centrality13 (20.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GDF10,NFE2L2 All fusions
Proteins found in more fusions CREBBP (see 6 fusions); RBMX (see 3 fusions); PRKCH (see 1 fusions); UBE2E2 (see 1 fusions); AHR (see 1 fusions); ENC1 (see 1 fusions); TRIM28 (see 1 fusions); GSK3B (see 1 fusions); NQO1 (see 2 fusions); PRKCD (see 2 fusions); SIAH2 (see 1 fusions); CUL3 (see 1 fusions); SQSTM1 (see 5 fusions); UBC (see 1 fusions); MAPK9 (see 3 fusions); YY1 (see 2 fusions); TNNT1 (see 1 fusions); MYC (see 1 fusions); WAC (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GDF10parental protein100TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
2 NFE2L2parental protein620.0992808.682bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
3 AHRsuppressor60.6001.722HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
PAS_4 (PF08448, IPR013656): PAS fold
4 AKT1oncoprotein110.37817.208PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 ATF4oncoprotein100.38922.083bZIP_1 (PF00170, IPR004827): bZIP transcription factor
6 BACH1interactor80.4298.789BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
7 BPTFinteractor40.8330.667Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
DDT (PF02791, IPR004022, SM00571): DDT domain
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
GRP (PF07172, IPR010800): Glycine rich protein family
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
SDA1 (PF05285, IPR007949): SDA1
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
8 BRCA1suppressor180.29467.344BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
9 BTRConcoprotein120.309170.546WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
10 CDKN1Asuppressor90.6943.835CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
11 COPS7Ainteractor40.5002.500PCI (PF01399, IPR000717, SM00088): PCI domain
12 CREB3interactor60.6002.500bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
13 CREBBPsuppressor190.44447.264Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
14 CUL3protein found in more fusions150.28653.700Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
15 EIF2AK3interactor100OATP (PF03137, IPR004156): Organic Anion Transporter Polypeptide (OATP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
PQQ_2 (PF13360, IPR002372): PQQ-like domain
16 ENC1oncoprotein51.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
HTH_12 (PF08461, IPR013668): Ribonuclease R winged-helix domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
17 FBXW11interactor90.35719.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
18 GADD45GIP1suppressor21.0000CR6_interact (PF10147, IPR018472): Growth arrest and DNA-damage-inducible proteins-interacting protein 1
19 GSK3Bsuppressor90.35717.800Pkinase (PF00069, IPR000719): Protein kinase domain
20 HDAC1suppressor190.37362.245FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
21 HDAC2suppressor140.47422.530Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
22 HDAC3suppressor140.44927.747Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
23 JUNoncoprotein180.36056.060bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
24 KEAP1oncoprotein110.44425.667BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
25 KPNA3interactor30.6670.500Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
26 KRASoncoprotein40.333126.000Ras (PF00071, IPR001806, SM00173): Ras family
27 MAFoncoprotein70.4675.800bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Maf_N (PF08383, IPR013592): Maf N-terminal region
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen
TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
28 MAFFinteractor50.8330.500bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
29 MAFGoncoprotein70.5335.667bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
ThrE_2 (PF12821, IPR024528): Threonine/Serine exporter, ThrE
30 MAFKoncoprotein70.5245.908bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
31 MAP2K1oncoprotein70.53396.176Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
32 MAP2K2interactor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
33 MAPK7oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
34 MAPK8oncoprotein110.44421.938DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
35 MAPK9suppressor60.8000.508Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
36 MYConcoprotein180.39075.377HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
37 NCOR1oncoprotein120.50021.510BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
38 NCOR2oncoprotein130.47431.023CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Spt20 (PF12090, IPR021950): Spt20 family
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
39 NFE2interactor80.42911.090bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Peptidase_Mx (PF15887, IPR031321): Putative zinc-binding metallo-peptidase
40 NFE2L3interactor80.38110.333bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
41 NQO1oncoprotein200Flavodoxin_2 (PF02525, IPR003680): Flavodoxin-like fold
42 PGAM5interactor40.6671.000His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
43 PMF1interactor21.0000Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Nnf1 (PF03980, IPR007128): Nnf1
CCAP (PF11105, IPR024276): Arthropod cardioacceleratory peptide 2a
44 PRKCAinteractor40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
45 PRKCDsuppressor50.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
46 PRKCGinteractor200C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
47 PRKCHprotein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
48 PRKCQinteractor40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
49 RBM45interactor60.8001.167RNA_bind (PF08675, IPR014789): RNA binding domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
50 RBMXsuppressor50.6671.167RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
51 RNF4interactor90.4649.300Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
52 SIAH2oncoprotein31.0000Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
53 SMARCA4suppressor120.59113.149DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
54 SQSTM1oncoprotein110.44418.667PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
55 SUMO1interactor70.6672.556Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
56 SUMO2interactor80.6673.075Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
57 TCF20interactor40.6671.000tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
58 TNNT1protein found in more fusions200Troponin (PF00992, IPR001978): Troponin
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
59 TRIM24suppressor50.5001.389PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
zf-MYND (PF01753, IPR002893): MYND finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
Imm68 (PF15583, IPR028276): Immunity protein 68
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
60 TRIM28protein found in more fusions140.42329.144ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
61 UBCprotein found in more fusions130.40935.019ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
62 UBE2E2protein found in more fusions70.5332.908UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
63 UBE2E3interactor60.7001.067UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
64 WACprotein found in more fusions200DUF1319 (PF07028, IPR010746): Protein of unknown function (DUF1319)
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
WW (PF00397, IPR001202, SM00456): WW domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
65 YY1protein found in more fusions70.8670.508zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail

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