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Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)102
The number (and %) of the onco-proteins28 (27.45 %)
The number (and %) of the tumor suppressors16 (15.69 %)
Total number of binary PPIs (saturation %)737 (14.31 %)
The number (and %) of affected PPIs101 (13.70 %)
The number of possible different fusions20
PPI diameter4
PPI radius2
The average degree of PPI13.706
Assortativity coefficient-0.1103
The network average Clustering coefficient0.433
The number (and %) of a zero Clustering coefficients3 (2.94 %)
The number (and %) of a zero Betweenness Centrality8 (7.84 %)


List of the fusions

PPI for parental proteins: DAZAP1,IDH3G All fusions
Proteins found in more fusions TKT (see 5 fusions); CUL7 (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); RAC1 (see 1 fusions); MYC (see 1 fusions); EWSR1 (see 2 fusions); PCBP2 (see 3 fusions); MDH2 (see 1 fusions); PRDX1 (see 1 fusions); RACK1 (see 3 fusions); NQO1 (see 2 fusions); COPS5 (see 1 fusions); RAC1/PKM (see 1 fusions); RACK1/FN1 (see 1 fusions); EZH2 (see 1 fusions); SOD1/TAGLN2 (see 1 fusions); RPA1 (see 1 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 DAZAP1parental protein770.1563181.545RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
2 IDH3Gparental protein240.123650.025Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
3 AASDHPPTinteractor100ACPS (PF01648, IPR008278): 4'-phosphopantetheinyl transferase superfamily
4 ACO2interactor40.33310.467Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
5 ADKinteractor80.42910.561PfkB (PF00294, IPR011611): pfkB family carbohydrate kinase
6 ADRB2interactor130.288107.4887tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7 AGPSinteractor21.0000FAD-oxidase_C (PF02913, IPR004113): FAD linked oxidases, C-terminal domain
FAD_binding_4 (PF01565, IPR006094): FAD binding domain
8 AHSA1interactor50.6006.839Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
9 AKR1A1interactor100.48911.440Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
10 ARF4interactor120.33337.858Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
11 ARF5interactor50.6003.342Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
12 ASS1suppressor160.36260.235Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
13 ATOX1interactor41.0000HMA (PF00403, IPR006121): Heavy-metal-associated domain
14 BCORoncoprotein60.10023.896Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
15 BMI1oncoprotein110.44434.533zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
16 BRCA1suppressor110.31116.560BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
17 CAND1interactor210.57424.207Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
18 CAPGsuppressor70.6193.778Gelsolin (PF00626, IPR007123): Gelsolin repeat
19 CARHSP1interactor30.6670.200DUF4339 (PF14237, IPR025640): Domain of unknown function (DUF4339)
20 CDV3interactor60.40022.953TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein
CDV3 (PF15359, IPR026806): Carnitine deficiency-associated protein 3
21 CFL1interactor240.308123.664Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
22 COPS5protein found in more fusions230.54136.532JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
23 CRIP1interactor90.5009.824LIM (PF00412, IPR001781, SM00132): LIM domain
24 CUL1suppressor250.42895.551Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25 CUL2suppressor190.60231.680Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
26 CUL3protein found in more fusions300.365191.184Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
27 CUL4Boncoprotein130.7695.130Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
28 CUL5suppressor180.61438.769Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
29 CUL7protein found in more fusions230.329189.109ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
30 DAZ1interactor31.0000DUF1970 (PF09301, IPR015380): Domain of unknown function (DUF1970)
Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
WRC (PF08879, IPR014977): WRC
DUF2582 (PF10771, IPR019707): Winged helix-turn-helix domain (DUF2582)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
31 DAZLinteractor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
32 DUTinteractor90.44411.323dUTPase (PF00692, IPR008180): dUTPase
33 DYNLL1interactor80.4764.770Dynein_light (PF01221, IPR001372): Dynein light chain type 1
34 EDF1interactor201.210MBF1 (PF08523, IPR013729): Multiprotein bridging factor 1
HTH_3 (PF01381, IPR001387, SM00530): Helix-turn-helix
35 ELAVL1oncoprotein430.218780.381RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
36 EWSR1oncoprotein340.277468.417RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
37 EZH2suppressor100.58312.696CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
38 FAHD1interactor50.7000.884FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
39 FHsuppressor100.44416.039Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
40 FN1oncoprotein300.294191.353fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
41 FUBP3interactor170.33840.426DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
42 GLOD4interactor110.49119.691Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
43 HNRNPKoncoprotein280.296219.691ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
44 IDH1suppressor120.288227.150Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
45 IDH2oncoprotein50.9000.333Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
46 IDH3Ainteractor100.35697.216Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
47 IDH3Binteractor70.5719.007Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
48 ITCHinteractor110.37829.891C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
49 ITGA4interactor250.322163.175FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
50 KPNA2interactor190.234118.719Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
51 MDH2protein found in more fusions150.29778.984Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
52 MPIinteractor60.4673.289PMI_typeI (PF01238, IPR001250): Phosphomannose isomerase type I
53 MTAPsuppressor100.37820.313PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
54 MYConcoprotein180.221158.611HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
55 NANSinteractor120.47017.780NeuB (PF03102, IPR013132): NeuB family
SAF (PF08666, IPR013974, SM00858): SAF domain
56 NEDD8interactor150.60420.051ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
57 NQO1oncoprotein60.7002.233Flavodoxin_2 (PF02525, IPR003680): Flavodoxin-like fold
58 OBSL1interactor190.34683.392BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
59 PAICSinteractor110.57810.016AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
60 PCBP1oncoprotein390.255527.032Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
61 PCBP2protein found in more fusions240.43176.806Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
62 PFN1suppressor110.45512.512Profilin (PF00235, IPR005455, SM00392): Profilin
63 PIN1suppressor140.35252.329Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
64 PIRinteractor150.33346.847Pirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
65 PKMoncoprotein250.347123.559PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
66 POU5F1oncoprotein120.12764.152Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
67 PPP1R12Ainteractor70.57117.463DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
68 PQBP1interactor50.30011.927WW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
69 PRDX1oncoprotein280.282138.509AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
70 PRDX2interactor210.38177.271AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
71 PSAT1interactor80.32111.305Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
72 RAB8Aoncoprotein60.53317.571Ras (PF00071, IPR001806, SM00173): Ras family
73 RAC1oncoprotein90.5368.377Ras (PF00071, IPR001806, SM00173): Ras family
74 RACK1suppressor240.37293.626WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
75 RAD52oncoprotein80.6193.198Rad52_Rad22 (PF04098, IPR007232): Rad52/22 family double-strand break repair protein
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
76 RBM12interactor60.5333.457RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
77 RNF2interactor130.37953.725zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
78 RPA1suppressor190.43177.187Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
79 RPA2oncoprotein160.50853.790RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
80 RPA3interactor160.49549.371Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
81 RSU1interactor50.7001.128LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
82 SBDSoncoprotein70.19041.941SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
83 SCP2interactor60.40063.819SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family
Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
84 SERPINH1interactor120.242136.707Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
85 SH3BGRLinteractor100SH3BGR (PF04908, IPR006993): SH3-binding, glutamic acid-rich protein
86 SNX12interactor60.4673.267PX (PF00787, IPR001683, SM00312): PX domain
87 SNX3interactor180.209160.408PX (PF00787, IPR001683, SM00312): PX domain
88 SOD1protein found in more fusions210.300101.588Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
89 SPRinteractor120.288104.033adh_short (PF00106, IPR002198): short chain dehydrogenase
90 SUGP1interactor110.21887.114G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
91 SUZ12suppressor120.43622.471DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
92 TAGLN2protein found in more fusions220.268129.978Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
93 TALDO1interactor120.42432.300TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
94 TIA1interactor170.35389.368Calcipressin (PF04847, IPR006931): Calcipressin
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
95 TIAL1interactor270.291160.114RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
96 TIMM44interactor60.4677.627Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
RecG_N (PF17190): RecG N-terminal helical domain
97 TKTprotein found in more fusions260.293212.193Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
98 TRIAP1oncoprotein21.0000UPF0203 (PF05254, IPR007918): Uncharacterised protein family (UPF0203)
99 UBE2L3interactor140.29567.742UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
100 UQCRFS1P1interactor21.0000NA
101 VCAM1interactor220.303130.239C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
102 WWOXsuppressor50.5003.539adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain

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