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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TSR2, FAM162A (from a repository: Tue Aug 13 05:02:50 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins4 (14.29 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)43 (11.38 %)
The number (and %) of affected PPIs26 (60.47 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI2.643
Assortativity coefficient-0.4357
The network average Clustering coefficient0.254
The number (and %) of a zero Clustering coefficients15 (53.57 %)
The number (and %) of a zero Betweenness Centrality18 (64.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TSR2,FAM162A All fusions
Proteins found in more fusions HSP90AA1 (see 6 fusions); PIAS2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TSR2parental protein80.071280.000WGG (PF10273, IPR019398): Pre-rRNA-processing protein TSR2
2 FAM162Aparental protein180.046520.667DUF1075 (PF06388, IPR009432): Protein of unknown function (DUF1075)
3 ADRB2interactor40.6671.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 BSGinteractor100Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
5 BYSLinteractor21.0000Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
6 CPVLinteractor100Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
7 DDX24interactor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tti2 (PF10521, IPR018870): Tti2 family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
8 GABARAPL2interactor100Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
9 HACL1interactor200TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
10 HSP90AA1oncoprotein40.6677.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
11 IWS1interactor100DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
12 KIFC3oncoprotein200Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
13 MRPL22interactor100Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
14 NDUFA4interactor50.50011.667B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
15 PIAS2protein found in more fusions200SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
16 PTRFinteractor100PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
17 RMDN3interactor100TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_16 (PF13432): Tetratricopeptide repeat
18 RPS26interactor40.167304.667Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
19 SIAEinteractor100SASA (PF03629, IPR005181): Carbohydrate esterase, sialic acid-specific acetylesterase
20 SLC25A1interactor30.333141.000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
21 SRRTinteractor100ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3546 (PF12066, IPR021933): Domain of unknown function (DUF3546)
DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
22 SSR3interactor30.6671.000TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
23 TIMM23Binteractor100Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
24 TM9SF4interactor100EMP70 (PF02990, IPR004240): Endomembrane protein 70
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
25 UBL4Ainteractor40.333166.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
26 USP39oncoprotein21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
27 VDAC2interactor30.6671.000Porin_3 (PF01459, IPR027246): Eukaryotic porin
28 ZBTB9interactor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
PRIMA1 (PF16101): Proline-rich membrane anchor 1

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