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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HSPB8, TAGLN (from a repository: Mon Apr 10 11:29:53 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)68
The number (and %) of the onco-proteins11 (16.18 %)
The number (and %) of the tumor suppressors5 (7.35 %)
Total number of binary PPIs (saturation %)293 (12.86 %)
The number (and %) of affected PPIs68 (23.21 %)
The number of possible different fusions7
PPI diameter4
PPI radius2
The average degree of PPI7.941
Assortativity coefficient-0.1780
The network average Clustering coefficient0.454
The number (and %) of a zero Clustering coefficients13 (19.12 %)
The number (and %) of a zero Betweenness Centrality19 (27.94 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HSPB8,TAGLN All fusions
Proteins found in more fusions KIF11 (see 1 fusions); SF1 (see 1 fusions); BAG3 (see 4 fusions); HSPB1 (see 4 fusions); JAK1 (see 1 fusions); HINT1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HSPB8parental protein180.110802.978Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
2 TAGLNparental protein500.1372167.865Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
3 ACAA2interactor90.55634.851Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ACDinteractor70.57129.187TPP1 (PF10341, IPR019437): Shelterin complex subunit, TPP1/ACD
5 ACTA1interactor60.33379.833Actin (PF00022, IPR004000, SM00268): Actin
6 ALDOAinteractor130.51546.909Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
7 ALDOCinteractor90.50033.263Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
8 ASB4interactor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
9 BAG3oncoprotein160.200607.080BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
10 CFL1interactor100.42218.458Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
11 CIAPIN1interactor200CIAPIN1 (PF05093, IPR007785): Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Methyltransf_31 (PF13847, IPR025714): Methyltransferase domain
12 CRYABoncoprotein60.7005.569Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
13 DNAJB6interactor40.33317.934DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
14 DSTNinteractor70.095121.746Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
15 DUSP12interactor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
16 DUSP6suppressor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
17 EEF2interactor60.46731.851EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
18 ENO1oncoprotein210.433207.484Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
19 ENO2interactor200.50063.897Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
20 ENO3interactor160.65066.973Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
21 FABP3suppressor31.0000Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
22 FABP5interactor130.57717.243Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
23 FABP7interactor21.0000Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
24 FKBP1Ainteractor170.54264.251FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
25 FKBP1Binteractor100.7118.748FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
26 FKBP2interactor150.60021.854FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
27 GIPC1interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
28 GPX4interactor140.61517.698GSHPx (PF00255, IPR000889): Glutathione peroxidase
29 GSTO1interactor50.40030.398GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
30 HINT1suppressor190.51654.785HIT (PF01230, IPR001310): HIT domain
31 HSD17B10interactor160.55027.209adh_short (PF00106, IPR002198): short chain dehydrogenase
32 HSPB1oncoprotein110.267160.432HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
33 HSPB2interactor100.250203.977Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
34 HSPB3interactor21.0000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
35 HSPB6interactor40.8332.705Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
36 HSPB7suppressor100HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
37 HSPE1interactor140.44053.908Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
38 ISG15suppressor110.29196.952ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
39 JAK1oncoprotein200FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
40 KCTD13interactor200BTB_2 (PF02214, IPR003131): BTB/POZ domain
41 KIF11protein found in more fusions200Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
42 MRPL53interactor50.6003.400MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
43 NCF1interactor200p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
44 NDUFA7interactor40.6671.733CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
45 NME1-NME2interactor140.49568.546NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
46 NME2interactor130.65226.108NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
47 NUTF2interactor51.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
48 PGDoncoprotein60.4674.5306PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
49 PIK3CDoncoprotein100PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
50 PLS3interactor60.5336.330CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
51 POT1interactor80.6198.083POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
52 PPIBinteractor130.55130.159Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
53 QRICH1interactor3017.209CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
54 RBM27interactor30.6670.500DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
PWI (PF01480, IPR002483, SM00311): PWI domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)
DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
55 RNF14interactor200IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
RWD (PF05773, IPR006575, SM00591): RWD domain
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-RING_11 (PF17123, IPR001841): RING-like zinc finger
56 S100A9oncoprotein305.915S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
57 SARNPoncoprotein21.0000SAP (PF02037, IPR003034, SM00513): SAP domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
Prok-E2_A (PF14457, IPR032865): Prokaryotic E2 family A
58 SF1protein found in more fusions40.6671.000UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
59 SNCAinteractor70.53315.221Synuclein (PF01387, IPR001058): Synuclein
60 SNX12interactor21.0000PX (PF00787, IPR001683, SM00312): PX domain
61 SNX3interactor70.42911.777PX (PF00787, IPR001683, SM00312): PX domain
62 SRPRBinteractor50.5006.000MHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
63 STIP1interactor160.392164.402TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
64 SUGP1interactor70.42962.154G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
65 TINF2interactor60.9001.641TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
66 UCHL3interactor120.54528.076Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
67 XPO1interactor60.13393.178CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
68 YKT6interactor31.0000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain

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