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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)47
The number (and %) of the onco-proteins11 (23.40 %)
The number (and %) of the tumor suppressors4 (8.51 %)
Total number of binary PPIs (saturation %)90 (8.33 %)
The number (and %) of affected PPIs45 (50.00 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI3.277
Assortativity coefficient-0.4511
The network average Clustering coefficient0.402
The number (and %) of a zero Clustering coefficients18 (38.30 %)
The number (and %) of a zero Betweenness Centrality29 (61.70 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ARHGAP26,HINFP All fusions
Proteins found in more fusions TLE3 (see 1 fusions); ATN1 (see 1 fusions); PTK2 (see 3 fusions); TP53 (see 3 fusions); MBD2 (see 1 fusions); THAP7 (see 1 fusions); SREBF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARHGAP26parental protein90.083307.133Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
SH3_9 (PF14604, IPR001452): Variant SH3 domain
BAR_3 (PF16746): BAR domain of APPL family
2 HINFPparental protein360.0321613.020SLIDE (PF09111, IPR015195): SLIDE
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
3 ACADSinteractor100Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 ATN1protein found in more fusions200Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
5 C2CD2interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF2057 (PF09829, IPR018635): Uncharacterized protein conserved in bacteria (DUF2057)
6 CCDC36interactor100DUF4700 (PF15771, IPR031529): Domain of unknown function (DUF4700)
7 CDC42oncoprotein50.167143.115Ras (PF00071, IPR001806, SM00173): Ras family
8 CDC42EP2interactor21.0000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
9 CDYL2interactor30.6670.667Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
10 EFTUD2interactor31.0000EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
11 ELP4interactor21.0000A_deaminase_N (PF08451, IPR013659): Adenosine/AMP deaminase N-terminal
PAXNEB (PF05625, IPR008728): PAXNEB protein
12 GSPT1oncoprotein100GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
13 JUNDoncoprotein100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
14 MBD2oncoprotein200API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
MBD_C (PF14048, IPR025884): C-terminal domain of methyl-CpG binding protein 2 and 3
MBDa (PF16564, IPR032343): p55-binding region of Methyl-CpG-binding domain proteins MBD
15 MDC1suppressor40.50015.390FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
16 MIF4GDinteractor100MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
17 MKI67interactor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
K167R (PF08065, IPR012568): K167R (NUC007) repeat
PP1_bind (PF15276, IPR029334): Protein phosphatase 1 binding
AROS (PF15684, IPR023262): Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1
18 MORF4L1interactor200MRG (PF05712, IPR026541): MRG
Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
19 MOV10interactor40.6677.419AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
20 NIPBLoncoprotein100DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Zip (PF02535, IPR003689): ZIP Zinc transporter
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
Cohesin_HEAT (PF12765, IPR026003): HEAT repeat associated with sister chromatid cohesion
Nipped-B_C (PF12830, IPR024986): Sister chromatid cohesion C-terminus
HEAT_2 (PF13646): HEAT repeats
DNA_repr_REX1B (PF14966): DNA repair REX1-B
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
T3SS_basalb_I (PF17001, IPR012670): Type III secretion basal body protein I, YscI, HrpB, PscI
21 NPATinteractor21.0000Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
NPAT_C (PF15712, IPR031442): NPAT C terminus
22 NPDC1interactor100NPDC1 (PF06809, IPR009635): Neural proliferation differentiation control-1 protein (NPDC1)
23 NXF1interactor60.4006.971NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
24 PKN3interactor100HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
25 POM121Cinteractor100T2SSC (PF11356): Type II secretion system protein C
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
POM121 (PF15229): POM121 family
26 PRRC2Cinteractor21.0000BAT2_N (PF07001, IPR009738): BAT2 N-terminus
Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist
GRP (PF07172, IPR010800): Glycine rich protein family
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
DUF4661 (PF15576, IPR029073): Domain of unknown function (DUF4661)
PET117 (PF15786, IPR031568): PET assembly of cytochrome c oxidase, mitochondrial
27 PTENsuppressor30.66733.039DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
28 PTK2protein found in more fusions50.66735.206FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
29 RBM17interactor21.0000G-patch (PF01585, IPR000467, SM00443): G-patch domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
Slu7 (PF11708, IPR021715): Pre-mRNA splicing Prp18-interacting factor
30 RBM26interactor100Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking
PWI (PF01480, IPR002483, SM00311): PWI domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TT_ORF1 (PF02956, IPR004219): TT viral orf 1
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
31 RHOAsuppressor2038.609Ras (PF00071, IPR001806, SM00173): Ras family
32 RPUSD4interactor40.6674.233PseudoU_synth_2 (PF00849, IPR006145): RNA pseudouridylate synthase
33 SHMT2interactor30.33391.942SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
34 SREBF2protein found in more fusions31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
35 SRPK1interactor60.200155.365FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
36 SRRM2interactor40.50041.361cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
37 THAP7protein found in more fusions31.0000THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
38 TLE3protein found in more fusions200TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
39 TP53suppressor120.164370.262DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
40 TRA2Binteractor30.33335.413RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
41 TRAF2interactor50.33386.442MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
42 TRIM39interactor31.0000Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Prim_Zn_Ribbon (PF08273, IPR013237, SM00778): Zinc-binding domain of primase-helicase
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
43 TRIM44interactor100Agouti (PF05039, IPR007733, SM00792): Agouti protein
CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
Herpes_UL17 (PF04559, IPR007640): Herpesvirus UL17 protein
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
44 TTF2interactor100SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
zf-GRF (PF06839, IPR010666): GRF zinc finger
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
45 U2AF1oncoprotein40.50036.413DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509)
KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
46 ZBTB49interactor21.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
47 ZNHIT1interactor21.0000zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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