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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ADGRA2, SPINK1 (from a repository: Sat Aug 17 11:30:33 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)5
The number (and %) of the onco-proteins2 (40.00 %)
The number (and %) of the tumor suppressors1 (20.00 %)
Total number of binary PPIs (saturation %)5 (50.00 %)
The number (and %) of affected PPIs3 (60.00 %)
The number of possible different fusions2
PPI diameter4
PPI radius2
The average degree of PPI1.600
Assortativity coefficient-0.3333
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients5 (100.00 %)
The number (and %) of a zero Betweenness Centrality2 (40.00 %)


List of the fusions

PPI for parental proteins: SPINK1,ADGRA2 All fusions
Proteins found in more fusions UBE3A (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 SPINK1parental protein100Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain
2 ADGRA2parental protein206.0007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
Ig_3 (PF13927): Immunoglobulin domain
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
3 DLG1suppressor208.000L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
4 RYKoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
5 UBE3Aoncoprotein306.000HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A

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