Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZNF521, RALGPS2 (from a repository: Sun Aug 11 21:58:58 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins4 (25.00 %)
The number (and %) of the tumor suppressors4 (25.00 %)
Total number of binary PPIs (saturation %)45 (37.50 %)
The number (and %) of affected PPIs14 (31.11 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI4.625
Assortativity coefficient-0.0112
The network average Clustering coefficient0.679
The number (and %) of a zero Clustering coefficients1 (6.25 %)
The number (and %) of a zero Betweenness Centrality7 (43.75 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RALGPS2,ZNF521 All fusions
Proteins found in more fusions SFN (see 1 fusions); SMAD4 (see 3 fusions); YWHAG (see 1 fusions); YWHAZ (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RALGPS2parental protein40.8330.667PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
2 ZNF521parental protein100.311107.667zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zf-met (PF12874): Zinc-finger of C2H2 type
zf-met2 (PF12907): Zinc-binding
zf-ribbon_3 (PF13248): zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zinc_ribbon_9 (PF14369): zinc-ribbon
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
3 BRAPinteractor200BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
4 ELAVL1oncoprotein50.33353.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5 HDAC1suppressor80.6198.000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
6 LYSTinteractor30.33336.667Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4800 (PF16057): Domain of unknown function (DUF4800)
7 MBD3L1interactor51.0000MBD_C (PF14048, IPR025884): C-terminal domain of methyl-CpG binding protein 2 and 3
MBDa (PF16564, IPR032343): p55-binding region of Methyl-CpG-binding domain proteins MBD
8 MTA1oncoprotein60.73316.000BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
9 RBBP7suppressor51.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
10 SFNsuppressor41.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
11 SMAD1interactor41.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
12 SMAD4suppressor41.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
13 YWHABinteractor50.50014.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
14 YWHAGprotein found in more fusions60.60022.33314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
15 YWHAZprotein found in more fusions60.60014.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
16 ZNF219interactor51.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1

B a c k    t o    T o p ⇑