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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins USP49, CEPT1 (from a repository: Tue Aug 20 20:00:14 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)59
The number (and %) of the onco-proteins10 (16.95 %)
The number (and %) of the tumor suppressors3 (5.08 %)
Total number of binary PPIs (saturation %)129 (7.54 %)
The number (and %) of affected PPIs57 (44.19 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI3.932
Assortativity coefficient-0.4065
The network average Clustering coefficient0.324
The number (and %) of a zero Clustering coefficients24 (40.68 %)
The number (and %) of a zero Betweenness Centrality29 (49.15 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: USP49,CEPT1 All fusions
Proteins found in more fusions HUWE1 (see 4 fusions); COPA (see 1 fusions); PSMC5 (see 2 fusions); RUVBL1 (see 1 fusions); UBR5 (see 4 fusions); MYC (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 USP49parental protein380.0362081.274UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
2 CEPT1parental protein190.0411049.154CDP-OH_P_transf (PF01066, IPR000462): CDP-alcohol phosphatidyltransferase
3 ANKRD28interactor50.7004.155Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
4 ANKRD52interactor41.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
5 CDC42oncoprotein60.50024.848Ras (PF00071, IPR001806, SM00173): Ras family
6 CETN1interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7 CETN2interactor21.0000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
8 CETN3interactor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
DUF3741 (PF12552, IPR022212): Protein of unknown function (DUF3741)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
9 CHST15interactor100Sulfotransfer_3 (PF13469): Sulfotransferase family
10 COPAprotein found in more fusions3020.889Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
COPI_C (PF06957, IPR010714): Coatomer (COPI) alpha subunit C-terminus
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
11 CSNK2A2interactor3056.483Pkinase (PF00069, IPR000719): Protein kinase domain
12 DICER1suppressor200DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Dicer_dimer (PF03368, IPR005034): Dicer dimerisation domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
13 ELAVL1oncoprotein80.238189.068RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 F7interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
15 FKBP5interactor40.50044.008FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NuDC (PF16273, IPR032572): Nuclear distribution C domain
16 HADHAinteractor50.100154.0703HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
17 HIST2H2BEinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
18 HUWE1oncoprotein90.250173.040BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
19 IPO7interactor40.50039.708Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
DUF3730 (PF12530, IPR022542): Protein of unknown function (DUF3730)
20 IPO9interactor50.40045.552IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_EZ (PF13513): HEAT-like repeat
21 IQGAP1interactor40.33341.317CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
22 KIF22interactor100Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
HHH_3 (PF12836): Helix-hairpin-helix motif
23 KRR1interactor21.0000Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
KH_1 (PF00013, IPR004088, SM00322): KH domain
24 LRPPRCinteractor2016.475DED (PF01335, IPR001875, SM00031): Death effector domain
MA3 (PF02847, IPR003891, SM00544): MA3 domain
PPR (PF01535, IPR002885): PPR repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
TPR_19 (PF14559): Tetratricopeptide repeat
PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR
25 MCM6interactor31.0000MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
26 MYConcoprotein110.178274.783HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
27 MYH14interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
28 NUP85interactor100Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
29 OAZ1interactor100ODC_AZ (PF02100, IPR002993): Ornithine decarboxylase antizyme
30 PDCD2interactor30.6671.286PDCD2_C (PF04194, IPR007320): Programmed cell death protein 2, C-terminal putative domain
zf-MYND (PF01753, IPR002893): MYND finger
31 PPM1Ginteractor21.0000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
32 PPP5Cinteractor21.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PPP5 (PF08321, IPR013235): PPP5 TPR repeat region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
33 PPP6R1interactor70.52418.489CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
34 PPP6R2interactor50.9000.500SAMP (PF05924, IPR009224): SAMP Motif
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
35 PPP6R3interactor60.60088.813SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
36 PRKACAinteractor30147.350Pkinase (PF00069, IPR000719): Protein kinase domain
37 PSMC1interactor50.300125.615AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
38 PSMC5protein found in more fusions60.60061.554AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
39 QSOX2interactor100Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain
Evr1_Alr (PF04777, IPR017905): Erv1 / Alr family
Thioredoxin (PF00085, IPR013766): Thioredoxin
zf-HYPF (PF07503, IPR011125): HypF finger
Thioredoxin_2 (PF13098, IPR012336): Thioredoxin-like domain
40 RBCK1interactor200GAGA (PF09237, IPR015318): GAGA factor
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
41 RPN1oncoprotein60.40089.898Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
42 RUVBL1oncoprotein70.333153.632TIP49 (PF06068, IPR010339): TIP49 C-terminus
43 SHCBP1interactor100Methyltransf_10 (PF05971, IPR010286): Protein of unknown function (DUF890)
DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408)
Pectate_lyase_3 (PF12708, IPR024535): Pectate lyase superfamily protein
Beta_helix (PF13229): Right handed beta helix region
44 SHPRHsuppressor100SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
45 SLC33A1interactor100Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
46 SLC39A7interactor100Zip (PF02535, IPR003689): ZIP Zinc transporter
47 SMC6interactor200SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
48 STAMBPL1interactor100CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
49 STIP1interactor50.30073.385TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): WTAP/Mum2p family
50 TOMM40interactor30.33328.113Porin_3 (PF01459, IPR027246): Eukaryotic porin
51 TRIM35suppressor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3410 (PF11890, IPR024531): Domain of unknown function (DUF3410)
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
52 UBR5protein found in more fusions40.33333.825CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
53 UGGT1interactor21.0000Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
UDP-g_GGTase (PF06427, IPR009448): UDP-glucose:Glycoprotein Glucosyltransferase
54 USP44interactor30.6671.000SurA_N (PF09312, IPR015391): SurA N-terminal domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
55 VAPAinteractor50.30070.950DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
56 WDR62interactor200eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
57 XRCC3oncoprotein60.067210.768Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
58 YARS2interactor100S4 (PF01479, IPR002942, SM00363): S4 domain
tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
59 YIPF5interactor21.0000Yip1 (PF04893, IPR006977): Yip1 domain

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