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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)71
The number (and %) of the onco-proteins20 (28.17 %)
The number (and %) of the tumor suppressors4 (5.63 %)
Total number of binary PPIs (saturation %)190 (7.65 %)
The number (and %) of affected PPIs69 (36.32 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI4.817
Assortativity coefficient-0.4939
The network average Clustering coefficient0.369
The number (and %) of a zero Clustering coefficients31 (43.66 %)
The number (and %) of a zero Betweenness Centrality33 (46.48 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GAB1,OXLD1 All fusions
Proteins found in more fusions SHC1 (see 1 fusions); ALAS1 (see 1 fusions); PTPN11 (see 1 fusions); GRB2 (see 1 fusions); MARK2 (see 2 fusions); BAG3 (see 4 fusions); GAB2 (see 3 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); ACADVL (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GAB1parental protein250.247732.360PH (PF00169, IPR001849, SM00233): PH domain
2 OXLD1parental protein440.0113175.525Oxidored-like (PF09791, IPR019180): Oxidoreductase-like protein, N-terminal
3 AARS2oncoprotein2070.302tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
4 ACADVLprotein found in more fusions40.33395.840Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
5 ACOT9interactor30.333116.3984HBT (PF03061, IPR006683): Thioesterase superfamily
6 ACSF3interactor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
7 AK4interactor2088.017ADK (PF00406, IPR000850): Adenylate kinase
8 ALAS1protein found in more fusions200Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
Preseq_ALAS (PF09029, IPR015118): 5-aminolevulinate synthase presequence
9 ALDH5A1interactor100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
10 ARHGAP32oncoprotein100.8673.899PX (PF00787, IPR001683, SM00312): PX domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
11 ATPAF2interactor21.0000ATP12 (PF07542, IPR011419): ATP12 chaperone protein
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
12 AUHoncoprotein200ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
13 BAG3oncoprotein70.53312.322BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
14 C1QBPinteractor50.300143.859MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
15 C1orf220interactor100NA
16 CARS2interactor2088.017tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
17 CASP1oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
18 CETN3interactor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
DUF3741 (PF12552, IPR022212): Protein of unknown function (DUF3741)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
19 CLPXinteractor60.400367.637AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
ClpB_D2-small (PF10431, IPR019489, SM01086): C-terminal, D2-small domain, of ClpB protein
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
Sigma54_activ_2 (PF14532, IPR002078): Sigma-54 interaction domain
20 CPT2interactor100Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
21 CRKoncoprotein110.61828.056SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
22 CRKLoncoprotein100.77810.214SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
23 DYNLT1interactor21.0000Tctex-1 (PF03645, IPR005334): Tctex-1 family
24 EGFRoncoprotein210.242836.140Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
25 FMC1interactor50.40073.026Complex1_LYR_2 (PF13233): Complex1_LYR-like
26 GAB2oncoprotein140.56428.861PH (PF00169, IPR001849, SM00233): PH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
27 GLDCinteractor3070.302Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
Beta_elim_lyase (PF01212, IPR001597): Beta-eliminating lyase
GDC-P (PF02347, IPR020580): Glycine cleavage system P-protein
Pyridoxal_deC (PF00282, IPR002129): Pyridoxal-dependent decarboxylase conserved domain
28 GLSinteractor100Glutaminase (PF04960, IPR015868): Glutaminase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
29 GRAP2interactor30.6671.000NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
SH2 (PF00017, IPR000980, SM00252): SH2 domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
30 GRB2oncoprotein170.500367.607SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
31 GRPEL2interactor40.5006.364GrpE (PF01025, IPR000740): GrpE
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
32 GTF2A1Linteractor100TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
33 HIBCHinteractor40.5008.182ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
34 HSD17B8interactor21.0000adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
35 HVCN1interactor100Ion_trans (PF00520, IPR005821): Ion transport protein
SlyX (PF04102, IPR007236): SlyX
VGPC1_C (PF16799, IPR031844): C-terminal membrane-localisation domain of ion-channel, VCN1
36 IBA57interactor100GCV_T (PF01571, IPR006222): Aminomethyltransferase folate-binding domain
GCV_T_C (PF08669, IPR013977): Glycine cleavage T-protein C-terminal barrel domain
37 KIAA0391interactor21.0000PPR (PF01535, IPR002885): PPR repeat
DnaA_N (PF11638, IPR024633): DnaA N-terminal domain
PPR_2 (PF13041, IPR002885): PPR repeat family
PRORP (PF16953, IPR031595): Protein-only RNase P
38 MAP3K3oncoprotein40.6674.000PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
39 MARK2protein found in more fusions70.46756.481DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
40 METoncoprotein60.9331.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
TIG (PF01833, IPR002909): IPT/TIG domain
41 MGME1interactor100PDDEXK_1 (PF12705): PD-(D/E)XK nuclease superfamily
42 MMABinteractor100Cob_adeno_trans (PF01923, IPR016030): Cobalamin adenosyltransferase
43 MOCS1interactor100MoaC (PF01967, IPR002820): MoaC family
Mob_synth_C (PF06463, IPR010505): Molybdenum Cofactor Synthesis C
Radical_SAM (PF04055, IPR007197): Radical SAM superfamily
44 MST1Rsuppressor41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
TIG (PF01833, IPR002909): IPT/TIG domain
45 MTG2interactor100GTP1_OBG (PF01018, IPR006169): GTP1/OBG
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
MMR_HSR1_C (PF08438, IPR013646): GTPase of unknown function C-terminal
46 MTIF2interactor21.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
IF-2 (PF11987, IPR023115): Translation-initiation factor 2
47 MUTinteractor40.333105.569B12-binding (PF02310, IPR006158): B12 binding domain
MM_CoA_mutase (PF01642, IPR006099): Methylmalonyl-CoA mutase
48 NARS2interactor100tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
49 NDUFAF5interactor31.0000Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
50 NDUFAF7interactor100Methyltransf_28 (PF02636, IPR003788): Putative S-adenosyl-L-methionine-dependent methyltransferase
51 NTRK1oncoprotein210.242887.801I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
52 NUDT19interactor100NUDIX (PF00293, IPR000086): NUDIX domain
53 PARD3interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
54 PDK1interactor3088.017HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
55 PDSS2suppressor100polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
56 PIK3R1oncoprotein110.8893.577RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
57 PLCG1oncoprotein90.69417.530C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
58 POLGinteractor100DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
DNA_pol_A (PF00476, IPR001098, SM00482): DNA polymerase family A
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
59 POLRMTinteractor2070.302DUF615 (PF04751, IPR006839): Protein of unknown function (DUF615)
PSD2 (PF07624, IPR011478): Protein of unknown function (DUF1585)
RNA_pol (PF00940, IPR002092): DNA-dependent RNA polymerase
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
60 PRKCIinteractor31.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
61 PTPN11suppressor90.8933.077SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
62 PUS1interactor2088.017PseudoU_synth_1 (PF01416, IPR020097): tRNA pseudouridine synthase
63 ROCK1interactor30.66713.304FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
ZapB (PF06005, IPR009252): Cell division protein ZapB
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
PH (PF00169, IPR001849, SM00233): PH domain
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
Rho_Binding (PF08912, IPR015008): Rho Binding
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
64 SHC1oncoprotein140.62853.452PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
65 TOP3Aoncoprotein2070.302A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
Topoisom_bac (PF01131, IPR013497): DNA topoisomerase
Toprim (PF01751, IPR006171, SM00493): Toprim domain
zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-GRF (PF06839, IPR010666): GRF zinc finger
zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
66 TRIM15suppressor50.6671.667Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
67 TRMT2Binteractor100tRNA_U5-meth_tr (PF05958, IPR010280): tRNA (Uracil-5-)-methyltransferase
68 TRMT61Binteractor100GCD14 (PF08704, IPR014816): tRNA methyltransferase complex GCD14 subunit
69 TSFMinteractor2033.850EF_TS (PF00889, IPR014039): Elongation factor TS
70 UQCC1interactor21.0000Ubiq_cyt_C_chap (PF03981, IPR021150): Ubiquinol-cytochrome C chaperone
71 UQCC2interactor30.333180.126Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)

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