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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LCORL, PKD2 (from a repository: Tue Feb 6 22:14:43 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins3 (13.04 %)
The number (and %) of the tumor suppressors1 (4.35 %)
Total number of binary PPIs (saturation %)30 (11.86 %)
The number (and %) of affected PPIs22 (73.33 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.087
Assortativity coefficient-0.3052
The network average Clustering coefficient0.204
The number (and %) of a zero Clustering coefficients17 (73.91 %)
The number (and %) of a zero Betweenness Centrality20 (86.96 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PKD2,LCORL All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); PKD1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PKD2parental protein200.018335.000Ion_trans (PF00520, IPR005821): Ion transport protein
PKD_channel (PF08016, IPR013122): Polycystin cation channel
Tetraspannin (PF00335, IPR018499): Tetraspanin family
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
2 LCORLparental protein202.000Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family
DUF4553 (PF15090, IPR028104): Domain of unknown function (DUF4553)
3 ALG5interactor100Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
4 ATP1A1interactor21.0000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
5 BCAS4oncoprotein100NA
6 CANXinteractor100Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
7 CEP170interactor100FHA (PF00498, IPR000253, SM00240): FHA domain
DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254)
CEP170_C (PF15308, IPR029300): CEP170 C-terminus
8 CTBP1protein found in more fusions2002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
9 FAM3Dinteractor100ILEI (PF15711): Interleukin-like EMT inducer
10 GLRA2interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
11 GOLGA2interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
12 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
13 KRTAP10-3interactor40.6671.000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
14 KRTAP10-8interactor31.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
15 MAGEA6interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
16 MAGEA8interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
17 PICK1oncoprotein100Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
18 PKD1suppressor31.0000Stress-antifung (PF01657, IPR002902): Salt stress response/antifungal
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
PKD (PF00801, IPR000601, SM00089): PKD domain
PKD_channel (PF08016, IPR013122): Polycystin cation channel
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
REJ (PF02010, IPR002859): REJ domain
WSC (PF01822, IPR002889, SM00321): WSC domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
19 PLSCR1interactor21.0000Scramblase (PF03803, IPR005552): Scramblase
20 SRPRAinteractor100SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
SRP54 (PF00448, IPR000897, SM00962): SRP54-type protein, GTPase domain
SRP54_N (PF02881, IPR013822, SM00963): SRP54-type protein, helical bundle domain
21 TMEM248interactor100TMEM219 (PF14940): Transmembrane 219
22 TNNI3interactor100Troponin (PF00992, IPR001978): Troponin
Troponin-I_N (PF11636, IPR021666): Troponin I residues 1-32
23 TRPC1interactor200Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)

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