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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MSRB3, SUCLA2 (from a repository: Sun Jul 21 03:33:44 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)47
The number (and %) of the onco-proteins9 (19.15 %)
The number (and %) of the tumor suppressors7 (14.89 %)
Total number of binary PPIs (saturation %)122 (11.29 %)
The number (and %) of affected PPIs45 (36.89 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI4.511
Assortativity coefficient-0.2032
The network average Clustering coefficient0.364
The number (and %) of a zero Clustering coefficients14 (29.79 %)
The number (and %) of a zero Betweenness Centrality17 (36.17 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SUCLA2,MSRB3 All fusions
Proteins found in more fusions MRPL12 (see 1 fusions); RRM1 (see 1 fusions); EGFR (see 2 fusions); OXCT1 (see 1 fusions); GAPDH (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SUCLA2parental protein350.0691305.950ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
nsp7 (PF08716, IPR014828): nsp7 replicase
2 MSRB3parental protein100.044257.826SelR (PF01641, IPR002579): SelR domain
3 ACADMoncoprotein80.42919.974Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 AGFG1interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
5 AGO4interactor100ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
6 AGTRAPinteractor200AGTRAP (PF06396, IPR009436, SM00805): Angiotensin II, type I receptor-associated protein (AGTRAP)
7 ALAS2interactor100Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
Preseq_ALAS (PF09029, IPR015118): 5-aminolevulinate synthase presequence
8 ARL6IP1interactor31.0000Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
9 AZIN1interactor100Orn_Arg_deC_N (PF02784, IPR022644): Pyridoxal-dependent decarboxylase, pyridoxal binding domain
Orn_DAP_Arg_deC (PF00278, IPR022643): Pyridoxal-dependent decarboxylase, C-terminal sheet domain
10 CMTM5suppressor100MARVEL (PF01284, IPR008253): Membrane-associating domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
11 COQ9interactor50.33327.789COQ9 (PF08511, IPR013718): COQ9
12 DLSToncoprotein1002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
13 EGFRoncoprotein80.23892.751Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 ETFAinteractor70.42914.617ETF (PF01012, IPR014730, SM00893): Electron transfer flavoprotein domain
ETF_alpha (PF00766, IPR014731): Electron transfer flavoprotein FAD-binding domain
15 FAF2interactor50.5004.767DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
16 FAM9Binteractor31.0000Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
17 GAPDHoncoprotein40.33327.903Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
18 GOLGA2interactor3032.491ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
19 GRHPRinteractor40.16737.2652-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
20 HPDLinteractor100Glyoxalase_3 (PF13468, IPR025870): Glyoxalase-like domain
Glyoxalase_4 (PF13669): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
21 IDH3Ainteractor50.5005.786Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
22 LNX2interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
23 MAPK8IP2interactor4030.237BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
24 MOV10interactor80.036169.310AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
25 MRPL12protein found in more fusions40.6671.887Ribosomal_L12 (PF00542, IPR013823): Ribosomal protein L7/L12 C-terminal domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
26 MRPL58interactor50.30031.164RF-1 (PF00472, IPR000352): RF-1 domain
27 NADK2interactor100NAD_kinase (PF01513, IPR002504): ATP-NAD kinase
28 NFS1interactor40.6672.182Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
29 NIT2suppressor21.0000CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
30 NTRK1oncoprotein150.154266.853I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
31 NXF1interactor80.048134.584NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
32 OXCT1protein found in more fusions60.7004.519CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
33 PRDM4suppressor200zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Ecl1 (PF12855, IPR024368): Life-span regulatory factor
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
34 PSMC2interactor70.46741.839AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
35 PSMD14interactor40.6676.876JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
36 RAB2Aoncoprotein50.40033.743Ras (PF00071, IPR001806, SM00173): Ras family
37 RBM4suppressor30.33330.843RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
CompInhib_SCIN (PF11546, IPR021612): Staphylococcal complement inhibitor SCIN
38 RRM1oncoprotein31.0000ATP-cone (PF03477, IPR005144): ATP cone domain
Ribonuc_red_lgC (PF02867, IPR000788): Ribonucleotide reductase, barrel domain
Ribonuc_red_lgN (PF00317, IPR013509): Ribonucleotide reductase, all-alpha domain
39 S100A16interactor70.23875.930S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
40 SDHAsuppressor70.38147.306FAD_binding_2 (PF00890, IPR003953): FAD binding domain
Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term
41 SDHBsuppressor40.6672.182Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
42 SEC22Binteractor21.0000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
43 SSR4interactor30.6671.786TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
44 SUCLG1interactor50.7002.167CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
CoA_binding_2 (PF13380, IPR003781): CoA binding domain
45 TCF4suppressor2011.460CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
46 TRIP6interactor21.0000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
47 UBXN8interactor3030.015Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
UBX (PF00789, IPR001012, SM00166): UBX domain

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