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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FSHR, TRABD (from a repository: Tue May 16 03:54:56 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins5 (17.24 %)
The number (and %) of the tumor suppressors6 (20.69 %)
Total number of binary PPIs (saturation %)42 (10.34 %)
The number (and %) of affected PPIs27 (64.29 %)
The number of possible different fusions6
PPI diameter2
PPI radiusinf
The average degree of PPI2.207
Assortativity coefficient-0.4563
The network average Clustering coefficient0.301
The number (and %) of a zero Clustering coefficients18 (62.07 %)
The number (and %) of a zero Betweenness Centrality26 (89.66 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TRABD,FSHR All fusions
Proteins found in more fusions ILK (see 1 fusions); ZBTB16 (see 3 fusions); RNF40 (see 2 fusions); FOXO1 (see 1 fusions); UBC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TRABDparental protein130.013154.000TraB (PF01963, IPR002816): TraB family
2 FSHRparental protein140.044173.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
GnHR_trans (PF12369, IPR024635): Gonadotropin hormone receptor transmembrane region
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
3 AKT2oncoprotein21.0000PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 APPL1interactor40.6671.000ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
5 APPL2interactor21.0000PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
6 ATP12Ainteractor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
7 ATP2B2interactor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
ATP_Ca_trans_C (PF12424, IPR022141): Plasma membrane calcium transporter ATPase C terminal
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
8 BECN1suppressor31.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
9 CBX5suppressor31.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
10 DNAJC11suppressor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
11 FOXO1suppressor31.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
12 GRK2interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
13 GRK4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
14 GRK6interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
15 HIPK4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
16 HSDL1interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
17 HSP90AA4Pinteractor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
18 ILKsuppressor200Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
19 MT-RNR2interactor100NA
20 NME2interactor200NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
21 RNF40protein found in more fusions200BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EzrA (PF06160, IPR010379): Septation ring formation regulator, EzrA
FlgN (PF05130, IPR007809): FlgN protein
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SpoIIE (PF07228, IPR001932): Stage II sporulation protein E (SpoIIE)
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
22 S100A10oncoprotein200S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
23 TOMM40interactor100Porin_3 (PF01459, IPR027246): Eukaryotic porin
24 TOP1oncoprotein100DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TonB_N (PF16031): TonB N-terminal region
25 TUG1interactor100NA
26 UBCprotein found in more fusions31.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
27 UQCRQinteractor100UcrQ (PF02939, IPR004205): UcrQ family
28 YWHAQinteractor21.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
29 ZBTB16suppressor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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