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Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)5
The number (and %) of the onco-proteins2 (40.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)7 (70.00 %)
The number (and %) of affected PPIs4 (57.14 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.4082
The network average Clustering coefficient0.433
The number (and %) of a zero Clustering coefficients2 (40.00 %)
The number (and %) of a zero Betweenness Centrality4 (80.00 %)


List of the fusions

PPI for parental proteins: FXN All fusions
Proteins found in more fusions ACTN1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 FXNparental protein40.16710.000Frataxin_Cyay (PF01491, IPR002908): Frataxin-like domain
2 ACTN1protein found in more fusions200CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
3 LYRM4interactor31.0000Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
4 PICK1oncoprotein100Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
5 PMPCBinteractor21.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain

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