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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins18 (33.96 %)
The number (and %) of the tumor suppressors2 (3.77 %)
Total number of binary PPIs (saturation %)124 (9.00 %)
The number (and %) of affected PPIs52 (41.94 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI3.849
Assortativity coefficient-0.2352
The network average Clustering coefficient0.439
The number (and %) of a zero Clustering coefficients15 (28.30 %)
The number (and %) of a zero Betweenness Centrality22 (41.51 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TOP3B,PPIL2 All fusions
Proteins found in more fusions SSX2IP (see 1 fusions); CENPF (see 1 fusions); MIB1 (see 4 fusions); RPA1 (see 1 fusions); HSP90AA1 (see 6 fusions); THOC1 (see 2 fusions); MAPK14 (see 1 fusions); APP (see 5 fusions); NUDT21 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TOP3Bparental protein320.0401513.997Topoisom_bac (PF01131, IPR013497): DNA topoisomerase
Toprim (PF01751, IPR006171, SM00493): Toprim domain
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
2 PPIL2parental protein200.082679.518Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Ribosomal_S6 (PF01250, IPR000529): Ribosomal protein S6
zf-NOSIP (PF15906, IPR031790): Zinc-finger of nitric oxide synthase-interacting protein
3 ADAMTSL4interactor30.6671.000ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
4 APPprotein found in more fusions70.33393.591APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATP6AP2interactor200Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
6 BAIAP2interactor31.0000IMD (PF08397, IPR013606): IRSp53/MIM homology domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
7 BSGinteractor21.0000Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
8 CALM1interactor21.0000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
9 CENPFoncoprotein200APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
IncA (PF04156, IPR007285): IncA protein
Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Usp (PF00582, IPR006016): Universal stress protein family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
CENP-F_N (PF10481, IPR018463): Cenp-F N-terminal domain
CENP-F_C_Rb_bdg (PF10490, IPR018302): Rb-binding domain of kinetochore protein Cenp-F/LEK1
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
10 CHD8oncoprotein100BUD22 (PF09073, IPR015158): BUD22
CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
11 CHIC2oncoprotein21.0000Erf4 (PF10256, IPR019383): Golgin subfamily A member 7/ERF4 family
12 FAM96Ainteractor21.0000DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
13 FAM96Binteractor30.6671.000DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
14 FBLN5interactor100EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
15 FGL1interactor100Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
16 FKBP6interactor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
17 FOXL1oncoprotein100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
18 FXR1interactor70.46755.738Agenet (PF05641, IPR008395, SM00743): Agenet domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
FXR_C3 (PF16097, IPR032177): Fragile X-related 1 protein C-terminal region 3
19 GBAinteractor30.33393.865Glyco_hydro_30 (PF02055, IPR001139): Glycosyl hydrolase family 30 TIM-barrel domain
Glyco_hydro_30C (PF17189): Glycosyl hydrolase family 30 beta sandwich domain
20 GRNoncoprotein2019.754Granulin (PF00396, IPR000118, SM00277): Granulin
Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
21 HIST1H2BGoncoprotein2037.144Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
22 HSP90AA1oncoprotein90.250195.088HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
23 KANSL2interactor21.0000WRC (PF08879, IPR014977): WRC
zf-C3Hc3H (PF13891, IPR025927): Potential DNA-binding domain
24 KLC2interactor40.50014.000TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
25 KLC3interactor40.33336.091TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TPR_12 (PF13424): Tetratricopeptide repeat
26 KRTAP4-12interactor50.5003.000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
27 MAPK14oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
28 MIB1protein found in more fusions40.33343.421Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
29 MID2interactor31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
30 MMS19interactor30.33343.421DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
31 NTRK1oncoprotein170.075634.689I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32 NUDT21protein found in more fusions40.66719.754NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
33 PDGFRAoncoprotein31.0000Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
LAT (PF15234, IPR008359): Linker for activation of T-cells
34 PIM2oncoprotein30.6675.230Pkinase (PF00069, IPR000719): Protein kinase domain
35 PNMA2interactor100PNMA (PF14893, IPR026523): PNMA
36 POC1Ainteractor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
37 PRCConcoprotein21.0000PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
38 RECQL5oncoprotein2055.629DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
RecQ5 (PF06959, IPR010716): RecQ helicase protein-like 5 (RecQ5)
SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
TAtT (PF16811, IPR031823): TRAP transporter T-component
39 RPA1suppressor70.46737.254Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
40 RPL10suppressor2019.754Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
41 SNRPBinteractor30.33357.629LSM (PF01423, IPR001163): LSM domain
42 SPRED2interactor100Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
WH1 (PF00568, IPR000697, SM00461): WH1 domain
43 SSX2IPprotein found in more fusions31.0000ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
44 TDRD3interactor60.40015.406RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
TUDOR (PF00567, IPR002999, SM00333): Tudor domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
DUF3472 (PF11958, IPR021862): Domain of unknown function (DUF3472)
45 THOC1protein found in more fusions70.46769.151Death (PF00531, IPR000488, SM00005): Death domain
efThoc1 (PF11957, IPR021861): THO complex subunit 1 transcription elongation factor
46 THOC2interactor50.70023.254Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
47 TRIM23interactor3032.462Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
48 TRIM41interactor40.333190.201BUD22 (PF09073, IPR015158): BUD22
Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
RecR (PF02132, IPR023628): RecR protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3631 (PF12307, IPR022081): Protein of unknown function (DUF3631)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
49 TSNAXinteractor30.33356.591Translin (PF01997, IPR002848): Translin family
50 UPF2interactor40.33344.735DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
51 VPS26Binteractor21.0000Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
52 ZNF408interactor40.6672.314zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
53 ZNF830interactor2037.318Sec34 (PF04136, IPR007265): Sec34-like family
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding

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