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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CADM1, TIMM9 (from a repository: Tue May 8 03:14:32 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins7 (20.59 %)
The number (and %) of the tumor suppressors3 (8.82 %)
Total number of binary PPIs (saturation %)75 (13.37 %)
The number (and %) of affected PPIs32 (42.67 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.882
Assortativity coefficient-0.1144
The network average Clustering coefficient0.563
The number (and %) of a zero Clustering coefficients6 (17.65 %)
The number (and %) of a zero Betweenness Centrality13 (38.24 %)


List of the fusions

PPI for parental proteins: CADM1,TIMM9 All fusions
Proteins found in more fusions PRDX6 (see 1 fusions); SFPQ (see 6 fusions); LGALS3 (see 2 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CADM1parental protein70.095300.000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Syndecan (PF01034, IPR027789): Syndecan domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
2 TIMM9parental protein250.100761.800zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
3 ATF2oncoprotein200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
4 BAG3oncoprotein60.400202.800BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 CNBPoncoprotein20149.200zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-ribbon_3 (PF13248): zinc-ribbon domain
6 COX5Ainteractor30.6671.000COX5A (PF02284, IPR003204): Cytochrome c oxidase subunit Va
7 CTSAinteractor21.0000Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
8 DHX9oncoprotein40.333185.867DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
9 EPB41L3suppressor21.00004_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
10 HNRNPMinteractor30.6673.733RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M
Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
11 HTRA2suppressor40.6670.667Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32
PDZ_2 (PF13180, IPR001478): PDZ domain
Trypsin_2 (PF13365): Trypsin-like peptidase domain
12 LGALS3oncoprotein200Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
13 LIN7Ainteractor21.0000DUF932 (PF06067, IPR026325): Domain of unknown function (DUF932)
L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
14 MPP3interactor21.0000L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
15 MPSTinteractor50.5004.667Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
16 NADK2interactor30.6670.667NAD_kinase (PF01513, IPR002504): ATP-NAD kinase
17 NDUFV1interactor60.4677.333Complex1_51K (PF01512, IPR011538): Respiratory-chain NADH dehydrogenase 51 Kd subunit
NADH_4Fe-4S (PF10589, IPR019575, SM00928): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
SLBB (PF10531, IPR019554): SLBB domain
18 NIT2suppressor21.0000CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
19 NUDCinteractor100CS (PF04969, IPR007052): CS domain
D5_N (PF08706, IPR014818, SM00885): D5 N terminal like
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc.
NuDC (PF16273, IPR032572): Nuclear distribution C domain
20 OXCT1interactor60.5005.000CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
21 PRDX6protein found in more fusions40.6671.000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
22 PSMA6interactor20164.800Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
23 PTGES3interactor200CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
24 RPS15interactor21.0000Ribosomal_S19 (PF00203, IPR002222): Ribosomal protein S19
Prok_Ub (PF14454, IPR032866): Prokaryotic Ubiquitin
25 SART1interactor60.50013.733SART-1 (PF03343, IPR005011): SART-1 family
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
26 SEC22Binteractor30.6671.000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
27 SFPQoncoprotein60.5004.667GRP (PF07172, IPR010800): Glycine rich protein family
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
28 SLC25A6interactor40.8334.333Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
29 THOP1interactor21.0000Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
30 TIMM10interactor70.47623.400zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
31 TIMM13interactor50.6003.667zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
32 TIMM8Ainteractor31.0000dDENN (PF03455, IPR005112, SM00801): dDENN domain
zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
33 TIMM8Binteractor21.0000zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
34 UQCRFS1interactor40.8330.667Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region

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