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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)99
The number (and %) of the onco-proteins36 (36.36 %)
The number (and %) of the tumor suppressors17 (17.17 %)
Total number of binary PPIs (saturation %)646 (13.32 %)
The number (and %) of affected PPIs98 (15.17 %)
The number of possible different fusions20
PPI diameter5
PPI radius3
The average degree of PPI12.364
Assortativity coefficient-0.1384
The network average Clustering coefficient0.582
The number (and %) of a zero Clustering coefficients5 (5.05 %)
The number (and %) of a zero Betweenness Centrality17 (17.17 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SSBP2,RFWD2 All fusions
Proteins found in more fusions PTPN11 (see 1 fusions); CUL4A (see 4 fusions); FOXO1 (see 3 fusions); TRIM33 (see 1 fusions); SFN (see 1 fusions); DCAF1 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); CDK6 (see 1 fusions); MDM4 (see 2 fusions); MVP (see 2 fusions); UBE2D2 (see 1 fusions); EWSR1 (see 1 fusions); BAG3 (see 4 fusions); YWHAZ (see 5 fusions); FOS (see 4 fusions); COPS5 (see 1 fusions); DDB1 (see 4 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SSBP2parental protein220.216817.562SSDP (PF04503): Single-stranded DNA binding protein, SSDP
2 RFWD2parental protein760.1503580.988Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
3 ATF6interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
4 BAG3oncoprotein120.164195.430BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 BTBD2interactor90.8890.556BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHR (PF08005, IPR012983): PHR domain
6 CCT2interactor130.8216.326Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
7 CCT3interactor110.9450.411Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
8 CCT4interactor130.8216.326Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
9 CCT5interactor120.8482.802Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CCT6Ainteractor110.9450.411Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11 CCT7interactor120.78826.906Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
12 CCT8interactor130.8216.326Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13 CDK6suppressor60.30058.621Pkinase (PF00069, IPR000719): Protein kinase domain
14 CDKN1Bsuppressor160.425105.483CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
15 CLEC18Ainteractor100CXCXC (PF03128, IPR004153): CXCXC repeat
EGF_2 (PF07974, IPR013111): EGF-like domain
CAP (PF00188, IPR014044, SM00198): Cysteine-rich secretory protein family
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
16 COPS2suppressor220.68821.684YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
17 COPS3interactor260.63747.817RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
18 COPS4interactor280.56192.533DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
19 COPS5protein found in more fusions430.359803.156JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
20 COPS6interactor320.488182.416DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
21 COPS7Ainteractor220.76611.773PCI (PF01399, IPR000717, SM00088): PCI domain
22 COPS7Binteractor210.73821.628PCI (PF01399, IPR000717, SM00088): PCI domain
23 COPS8interactor200.8425.283CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
24 CRTC2oncoprotein30.6670.400TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus
TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
25 CUL1suppressor280.439129.435Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
26 CUL2suppressor190.63733.443Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27 CUL3protein found in more fusions380.345517.282Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
28 CUL4Aprotein found in more fusions290.56972.676Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
29 CUL4Boncoprotein270.57576.598Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
30 DCAF1protein found in more fusions180.71332.851DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
31 DCAF11interactor111.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
32 DDA1interactor190.77812.426DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
33 DDB1protein found in more fusions280.538337.395CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
34 DDB2suppressor240.56158.913WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
35 DET1interactor120.37932.724Det1 (PF09737, IPR019138): De-etiolated protein 1 Det1
36 DMC1interactor200Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
37 DYRK2interactor80.179130.750Pkinase (PF00069, IPR000719): Protein kinase domain
38 ELAVL1oncoprotein220.310323.124RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
39 ERCC8oncoprotein160.8583.563WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859)
40 ETS1oncoprotein50.7001.408Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
41 ETS2suppressor70.52413.549Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
42 ETV1oncoprotein50.4003.730Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
43 ETV4oncoprotein21.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
44 ETV5oncoprotein40.5002.628Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
45 EWSR1oncoprotein210.379515.480RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
46 FOSoncoprotein110.28933.563bZIP_1 (PF00170, IPR004827): bZIP transcription factor
47 FOSL2oncoprotein70.38111.437bZIP_1 (PF00170, IPR004827): bZIP transcription factor
48 FOXO1suppressor40.6670.336K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
49 HSPA2interactor50.6007.388HSP70 (PF00012, IPR013126): Hsp70 protein
50 HSPA6interactor60.66710.979HSP70 (PF00012, IPR013126): Hsp70 protein
51 HSPA8oncoprotein170.46357.724HSP70 (PF00012, IPR013126): Hsp70 protein
52 IDI2interactor70.8105.535NUDIX (PF00293, IPR000086): NUDIX domain
53 IL36RNinteractor31.0000IL1 (PF00340, IPR000975, SM00125): Interleukin-1 / 18
54 ISL1interactor100.444170.192LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
55 ISL2interactor70.619143.026LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
56 JUNoncoprotein160.229237.951bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
57 JUNBoncoprotein30.6670.286bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
58 JUNDoncoprotein70.5718.744bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
59 KLHL42interactor61.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
60 LDB1oncoprotein110.50935.412LIM_bind (PF01803): LIM-domain binding protein
61 LDB2interactor60.8002.730LIM_bind (PF01803): LIM-domain binding protein
62 LHX4suppressor60.7331.822LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
63 LHX6suppressor51.0000BON (PF04972, IPR007055, SM00749): BON domain
LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
64 LMO2oncoprotein60.40035.035CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
65 LMO4interactor80.464181.435LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
66 LMX1Binteractor51.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
67 LRR1interactor130.9101.325LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
68 MDM2oncoprotein200.351114.395Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
69 MDM4oncoprotein100.58310.871zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
70 MVPoncoprotein60.30035.597Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
71 PARP4interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
72 PIN1suppressor70.238162.219Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
73 PTPN1suppressor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
74 PTPN11suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
75 RB1CC1suppressor30.3338.786Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
76 RBX1oncoprotein270.54569.691zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
77 RCHY1suppressor90.57136.863C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
78 REG1Ainteractor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
79 SFNsuppressor70.6671.91314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
80 SIPA1oncoprotein100IncA (PF04156, IPR007285): IncA protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
81 SKP1oncoprotein150.552174.121Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
82 SSBP3oncoprotein150.381192.596SSDP (PF04503): Single-stranded DNA binding protein, SSDP
83 SSBP4oncoprotein140.44083.109SSDP (PF04503): Single-stranded DNA binding protein, SSDP
84 STK40interactor100.26737.480Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
85 TAL1oncoprotein60.8001.517HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
86 TCEB2interactor91.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
87 TCP1interactor120.8944.221Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
88 TOM1oncoprotein2014.920GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
89 TP53suppressor390.209585.368DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
90 TRIB1interactor50.6003.795Pkinase (PF00069, IPR000719): Protein kinase domain
91 TRIB2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
92 TRIB3interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
93 TRIM33oncoprotein110.422436.118PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
Spectrin (PF00435, IPR002017): Spectrin repeat
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
94 UBE2D1interactor130.348178.905UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
95 UBE2D2oncoprotein100.5567.603UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
96 WDR5interactor70.8570.297WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
97 YWHABinteractor80.42921.95814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
98 YWHAZprotein found in more fusions150.40769.48014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
99 ZNF397interactor30.33370.446SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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