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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PARD3B, DAPK2 (from a repository: Sun Dec 23 12:24:24 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)10
The number (and %) of the onco-proteins1 (10.00 %)
The number (and %) of the tumor suppressors1 (10.00 %)
Total number of binary PPIs (saturation %)17 (37.78 %)
The number (and %) of affected PPIs9 (52.94 %)
The number of possible different fusions4
PPI diameter4
PPI radius3
The average degree of PPI2.200
Assortativity coefficient-0.7416
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients10 (100.00 %)
The number (and %) of a zero Betweenness Centrality3 (30.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DAPK2,PARD3B All fusions
Proteins found in more fusions SFN (see 1 fusions); APP (see 4 fusions); DAPK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DAPK2parental protein7050.333GvpK (PF05121, IPR007805): Gas vesicle protein K
Pkinase (PF00069, IPR000719): Protein kinase domain
2 PARD3Bparental protein204.667PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
3 APPprotein found in more fusions3012.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 CEP250interactor205.333ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
5 FAM9Binteractor307.333Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
6 KLC3interactor200TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TPR_12 (PF13424): Tetratricopeptide repeat
7 LLGL2interactor200Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
8 RACGAP1interactor207.333RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
9 SFNsuppressor4012.33314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
10 TUBGCP5interactor100Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
GCP5-Mod21 (PF14609, IPR032797): gamma-Tubulin ring complex non-core subunit mod21

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