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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HSF2BP, SMUG1 (from a repository: Sun Jul 28 17:52:36 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)9
The number (and %) of the onco-proteins2 (22.22 %)
The number (and %) of the tumor suppressors1 (11.11 %)
Total number of binary PPIs (saturation %)15 (41.67 %)
The number (and %) of affected PPIs8 (53.33 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI2.000
Assortativity coefficient-0.2828
The network average Clustering coefficient0.167
The number (and %) of a zero Clustering coefficients6 (66.67 %)
The number (and %) of a zero Betweenness Centrality5 (55.56 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HSF2BP,SMUG1 All fusions
Proteins found in more fusions RBPMS (see 1 fusions); VAC14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HSF2BPparental protein4026.000DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
2 SMUG1parental protein40.16726.000UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
3 CDC73suppressor100CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
4 RBPMSprotein found in more fusions31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5 TRIP13interactor40.33332.000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
6 UBE2Iinteractor3030.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
7 UNGinteractor100UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
8 UPF2interactor200DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
9 VAC14oncoprotein200TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fig4_bd (PF11916, IPR021841): Vacuolar protein 14 C-terminal Fig4p binding
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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