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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)154
The number (and %) of the onco-proteins37 (24.03 %)
The number (and %) of the tumor suppressors13 (8.44 %)
Total number of binary PPIs (saturation %)1271 (10.79 %)
The number (and %) of affected PPIs158 (12.43 %)
The number of possible different fusions27
PPI diameter4
PPI radius2
The average degree of PPI15.649
Assortativity coefficient-0.1184
The network average Clustering coefficient0.543
The number (and %) of a zero Clustering coefficients15 (9.74 %)
The number (and %) of a zero Betweenness Centrality23 (14.94 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MED16,RBFOX2 All fusions
Proteins found in more fusions VDR (see 2 fusions); LZTR1 (see 2 fusions); U2AF2 (see 2 fusions); MAPK1IP1L (see 1 fusions); CUL3 (see 1 fusions); MYC (see 1 fusions); VAC14 (see 1 fusions); APC (see 1 fusions); DDX5 (see 1 fusions); RPA1 (see 1 fusions); THRA (see 3 fusions); PTBP1 (see 1 fusions); MAGED1 (see 1 fusions); VCP (see 4 fusions); MED21 (see 1 fusions); PRMT5 (see 2 fusions); FAM136A (see 1 fusions); ATXN1 (see 3 fusions); RBPMS (see 2 fusions); RBFOX2 (see 2 fusions); KHDRBS1 (see 1 fusions); ATN1 (see 1 fusions); QKI (see 3 fusions); EPAS1 (see 1 fusions); DAZAP2 (see 2 fusions); APH1A (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MED16parental protein640.3362260.421WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Med16 (PF11635, IPR021665): Mediator complex subunit 16
2 RBFOX2parental protein940.0709823.600RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
3 ACVR1interactor200Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
4 ANKRD40interactor31.0000Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
5 APCsuppressor40.33322.413APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
6 APH1Aoncoprotein40.6672.543Aph-1 (PF06105, IPR009294): Aph-1 protein
7 ATN1protein found in more fusions80.6196.456Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
8 ATXN1protein found in more fusions210.216329.817AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
9 ATXN1Linteractor80.5719.132AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
10 ATXN2interactor80.5718.377LsmAD (PF06741, IPR009604): LsmAD domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Spt20 (PF12090, IPR021950): Spt20 family
SM-ATX (PF14438, IPR025852): Ataxin 2 SM domain
11 AURKAoncoprotein60.20025.223Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
12 BCS1Linteractor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
BCS1_N (PF08740, IPR014851, SM01024): BCS1 N terminal
AAA_25 (PF13481): AAA domain
13 BMI1oncoprotein190.196306.561zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
14 BOLLinteractor31.0000NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 BRD7suppressor207.795HcyBio (PF01837, IPR002708): Homocysteine biosynthesis enzyme, sulfur-incorporation
GntR (PF00392, IPR000524, SM00345): Bacterial regulatory proteins, gntR family
Presenilin (PF01080, IPR001108): Presenilin
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3512 (PF12024, IPR021900): Domain of unknown function (DUF3512)
MAJIN (PF15077, IPR027816): Membrane-anchored junction protein
16 C19orf52interactor2010.258DUF2366 (PF10171, IPR019322): Uncharacterised conserved protein (DUF2366)
17 C1orf94interactor120.45531.257DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
18 CAMK2Boncoprotein50.50040.941CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
19 CCNCsuppressor300.87811.370Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
20 CDK19interactor290.87751.561Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
21 CDK8interactor410.638263.626Pkinase (PF00069, IPR000719): Protein kinase domain
22 CEBPEinteractor3047.095Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
23 CEP164interactor21.0000DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
WW (PF00397, IPR001202, SM00456): WW domain
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
24 CHAF1Ainteractor50.16751.291CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA
25 CLNS1Ainteractor40.8331.009Voldacs (PF03517): Regulator of volume decrease after cellular swelling
26 COPRSinteractor21.0000COPR5 (PF15340, IPR029289): Cooperator of PRMT5 family
27 CTDP1interactor170.80926.445Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
FCP1_C (PF09309, IPR015388): FCP1, C-terminal
NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
28 CUL3protein found in more fusions310.301350.427Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
29 DAB1interactor90.55613.238PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
30 DAZAP2protein found in more fusions120.63617.819DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
31 DDX5oncoprotein230.381241.307DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
32 DEDD2interactor50.5002.236DED (PF01335, IPR001875, SM00031): Death effector domain
33 DMRTB1interactor31.0000DM (PF00751, IPR001275, SM00301): DM DNA binding domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
34 DPH2interactor100Diphthamide_syn (PF01866, IPR002728): Putative diphthamide synthesis protein
35 EFNB2interactor100Ephrin (PF00812, IPR001799): Ephrin
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
36 EIF4G3interactor30.6670.111MA3 (PF02847, IPR003891, SM00544): MA3 domain
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
37 ELAVL1oncoprotein360.1851257.930RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
38 ELAVL2interactor50.6004.257RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
39 EMC2interactor90.47251.552TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
40 EPAS1suppressor220.805123.371Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
PAS_11 (PF14598): PAS domain
41 ESR1suppressor370.3711203.065Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
42 ESR2suppressor190.843272.336zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
43 FAM136Aprotein found in more fusions3070.394DUF842 (PF05811, IPR008560): Eukaryotic protein of unknown function (DUF842)
44 FBXO7interactor40.5002.125Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
F-box-like (PF12937, IPR001810): F-box-like
45 FBXW7suppressor320.658174.198Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
46 FNDC3Binteractor30.6671.547fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
47 FOSL2oncoprotein100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
48 GLIS2interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
49 GPATCH8interactor50.5005.424G-patch (PF01585, IPR000467, SM00443): G-patch domain
Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
Use1 (PF09753, IPR019150): Membrane fusion protein Use1
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
50 GTF2A1Linteractor30.333111.316TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
51 HECW2interactor100.19488.135C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
52 HELZinteractor40.6679.129PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
TetR_C_8 (PF14278): Transcriptional regulator C-terminal region
53 HIST1H3Ainteractor60.10058.683Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
54 HNF4Asuppressor130.8033.218zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
55 HNRNPABinteractor140.352108.995CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
GRP (PF07172, IPR010800): Glycine rich protein family
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462)
56 HNRNPFinteractor210.400265.384RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
57 HNRNPH2interactor130.54529.845RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
58 HNRNPKoncoprotein230.502101.208ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
59 HOXA5interactor30.6673.842Chorion_2 (PF03964, IPR005649): Chorion family 2
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Terminase_5 (PF06056, IPR010332): Putative ATPase subunit of terminase (gpP-like)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
60 JMJD4interactor100Cupin_4 (PF08007, IPR003347): Cupin superfamily protein
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
61 KAT2Ainteractor130.56129.897Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
62 KHDRBS1protein found in more fusions170.55862.514KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
63 LARP4Binteractor50.70021.721La (PF05383, IPR006630, SM00715): La domain
64 LZTR1oncoprotein70.067114.167BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
65 MAGED1protein found in more fusions160.32483.045MAGE (PF01454, IPR002190): MAGE family
66 MAPK1IP1Lprotein found in more fusions31.0000MISS (PF15822, IPR031653): MAPK-interacting and spindle-stabilising protein-like
67 MATR3interactor190.51092.630DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
68 MBNL1interactor60.7335.928zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-CCCH_3 (PF15663): Zinc-finger containing family
69 MED1interactor550.469655.197Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
70 MED10interactor370.75148.999Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
71 MED11interactor260.9453.045Med11 (PF10280, IPR019404): Mediator complex protein
72 MED12oncoprotein480.523492.081Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877)
Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain
Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
73 MED13oncoprotein360.72766.769Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal
Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
74 MED13Linteractor180.9740.486Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal
Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
75 MED14interactor470.535367.514Med14 (PF08638, IPR013947): Mediator complex subunit MED14
76 MED15interactor370.691210.934Med15 (PF09606, IPR019087): ARC105 or Med15 subunit of Mediator complex non-fungal
77 MED17oncoprotein490.523376.699Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
78 MED18interactor310.841107.779Med18 (PF09637, IPR019095): Med18 protein
79 MED19interactor330.8817.640Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
80 MED20interactor360.722108.076Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
81 MED21protein found in more fusions350.704115.839Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
82 MED23interactor440.606274.135Med23 (PF11573, IPR021629): Mediator complex subunit 23
83 MED24interactor440.592174.680Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
84 MED25interactor290.74637.478Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2
Med25_SD1 (PF11235, IPR021397): Mediator complex subunit 25 synapsin 1
Med25_NR-box (PF11244, IPR021406): Mediator complex subunit 25 C-terminal NR box-containing
Med25_VWA (PF11265, IPR021419): Mediator complex subunit 25 von Willebrand factor type A
85 MED26interactor360.77632.316Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
86 MED27interactor340.81133.269Med27 (PF11571, IPR021627): Mediator complex subunit 27
87 MED28interactor360.79779.901cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
Med28 (PF11594, IPR021640): Mediator complex subunit 28
88 MED29interactor380.77539.082Med29 (PF11568, IPR021018): Mediator complex subunit 29
89 MED30interactor310.86410.152Med30 (PF11315, IPR021019): Mediator complex subunit 30
90 MED4interactor460.554525.654Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
91 MED6interactor390.72357.576Med6 (PF04934, IPR007018): MED6 mediator sub complex component
Peptidase_M15 (PF01427, IPR000755): D-ala-D-ala dipeptidase
92 MED7interactor380.6561234.778Med7 (PF05983, IPR009244): MED7 protein
DotU (PF09850, IPR017732): Type VI secretion system protein DotU
93 MED8interactor340.82220.165Med8 (PF10232, IPR019364): Mediator of RNA polymerase II transcription complex subunit 8
94 MED9interactor330.83719.507Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
95 MSI2oncoprotein80.5713.295NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
96 MYConcoprotein190.294399.631HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
97 MYO1Cinteractor100.356110.754IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
98 NAF1interactor30.6671.000AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
99 NR2E3interactor50.30052.290zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
100 NTRK1oncoprotein430.1891644.807I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
101 OBFC1interactor170.85396.478STN1_2 (PF09170, IPR015253): CST, Suppressor of cdc thirteen homolog, complex subunit STN1
RUN (PF02759, IPR004012, SM00593): RUN domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
Stn1 (PF10451, IPR018856): Telomere regulation protein Stn1
102 OTUD4interactor21.0000OTU (PF02338, IPR003323): OTU-like cysteine protease
Presenilin (PF01080, IPR001108): Presenilin
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
103 PARLinteractor100Rhomboid (PF01694, IPR022764): Rhomboid family
104 PJA1interactor31.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
105 PLEKHB1oncoprotein21.0000PH (PF00169, IPR001849, SM00233): PH domain
Bacteriocin_IIc (PF10439, IPR019493): Bacteriocin class II with double-glycine leader peptide
106 POLR2Ginteractor190.8695.307SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
107 POLR3Dinteractor40.5002.236Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
108 PPARGC1Ainteractor120.7888.130Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
109 PRMT5protein found in more fusions150.187324.012PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
110 PRRC2Ainteractor130.35940.782BAT2_N (PF07001, IPR009738): BAT2 N-terminus
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
111 PSMA3interactor140.32181.179Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
112 PSMF1interactor60.6009.922PI31_Prot_C (PF08577, IPR013886): PI31 proteasome regulator
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
113 PTBP1oncoprotein150.60414.034RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
114 PUM1interactor70.4768.104K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
YppG (PF14179, IPR025555): YppG-like protein
115 PUM2interactor70.40051.201PC4 (PF02229, IPR003173): Transcriptional Coactivator p15 (PC4)
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
116 QKIprotein found in more fusions290.386914.521KH_1 (PF00013, IPR004088, SM00322): KH domain
STAR_dimer (PF16544, IPR032377): Homodimerisation region of STAR domain protein
Quaking_NLS (PF16551, IPR032367): Putative nuclear localisation signal of quaking
117 RALYinteractor130.43668.266RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
118 RBFOX1interactor160.40072.322RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
119 RBM22interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Torus (PF16131, IPR032297): Torus domain
120 RBM23interactor70.38110.136RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
RSRP (PF17069): Arginine/Serine-Rich protein 1
121 RBM38suppressor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
122 RBM42interactor50.50024.176RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
123 RBMS1interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
124 RBPMSprotein found in more fusions150.42961.712RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
125 RBPMS2interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
126 REREoncoprotein70.33387.303Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
127 RHOXF2interactor150.363148.181DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367)
GRP (PF07172, IPR010800): Glycine rich protein family
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
128 RIOK1interactor90.44494.114RIO1 (PF01163, IPR018934): RIO1 family
129 RNF8suppressor40.6670.600FHA (PF00498, IPR000253, SM00240): FHA domain
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
130 RPA1suppressor210.421132.587Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
131 RPA2oncoprotein190.456102.737RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
132 RPA3interactor200.47489.397Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
133 SF3A1interactor110.564153.115TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Surp (PF01805, IPR000061, SM00648): Surp module
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
134 SMN1interactor60.7002.017SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
135 SNRPCinteractor100.42245.570zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
136 SUPT3Hinteractor100.8004.926TFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit
DUF4093 (PF13331, IPR025156): Domain of unknown function (DUF4093)
137 SUPT7Linteractor70.9050.578Bromo_TP (PF07524, IPR006565): Bromodomain associated
138 TADA2Ainteractor270.590159.309SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
139 TCL1Boncoprotein140.9890.067TCL1_MTCP1 (PF01840, IPR004832): TCL1/MTCP1 family
140 THRAsuppressor90.9640.095C1_2 (PF03107, IPR004146): C1 domain
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
141 TOLLIPinteractor90.7148.556C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
142 TRAoncoprotein70.71415.769NA
143 TRMT61Ainteractor100GCD14 (PF08704, IPR014816): tRNA methyltransferase complex GCD14 subunit
GCD14_N (PF14801): tRNA methyltransferase complex GCD14 subunit N-term
144 TRRAPinteractor170.72126.532BALF1 (PF06861, IPR010677): BALF1 protein
BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
ACDC (PF14733, IPR028078): AP2-coincident C-terminal
145 U2AF2protein found in more fusions200.433162.616RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
146 UBAP2interactor31.0000Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
CUE (PF02845, IPR003892, SM00546): CUE domain
HlyE (PF06109, IPR027018): Haemolysin E (HlyE)
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF3697 (PF12478, IPR022166): Ubiquitin-associated protein 2
UBA_4 (PF14555): UBA-like domain
147 UNKinteractor70.42924.803MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
148 VAC14oncoprotein50.5004.711TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fig4_bd (PF11916, IPR021841): Vacuolar protein 14 C-terminal Fig4p binding
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
149 VCPprotein found in more fusions150.374165.569AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
150 VDRsuppressor150.703114.932zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
151 WBP11interactor70.38125.044BUD22 (PF09073, IPR015158): BUD22
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SspB (PF04386, IPR007481): Stringent starvation protein B
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ABC_trans_N (PF14510, IPR029481): ABC-transporter extracellular N-terminal
152 XRCC3oncoprotein40.50014.976Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
153 ZC3H13interactor270.755125.587FGF-BP1 (PF06473, IPR010510): FGF binding protein 1 (FGF-BP1)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
PET117 (PF15786, IPR031568): PET assembly of cytochrome c oxidase, mitochondrial
154 ZNF137Pinteractor2016.081NA

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