Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZFYVE26, BCCIP (from a repository: Mon Sep 9 14:36:35 2019)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)73
The number (and %) of the onco-proteins18 (24.66 %)
The number (and %) of the tumor suppressors6 (8.22 %)
Total number of binary PPIs (saturation %)286 (10.88 %)
The number (and %) of affected PPIs71 (24.83 %)
The number of possible different fusions13
PPI diameter5
PPI radius3
The average degree of PPI7.068
Assortativity coefficient-0.0625
The network average Clustering coefficient0.507
The number (and %) of a zero Clustering coefficients9 (12.33 %)
The number (and %) of a zero Betweenness Centrality14 (19.18 %)


List of the fusions

PPI for parental proteins: BCCIP,ZFYVE26 All fusions
Proteins found in more fusions SSX2IP (see 1 fusions); ITSN2 (see 5 fusions); ALAS1 (see 1 fusions); VCP (see 4 fusions); EGFR (see 2 fusions); NAGK (see 1 fusions); NPM1 (see 1 fusions); DDX18/DKC1 (see 1 fusions); DKC1 (see 2 fusions); SORD (see 1 fusions); THOC1 (see 2 fusions); HNRNPC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BCCIPparental protein520.1152751.793DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
BCIP (PF13862, IPR025602): p21-C-terminal region-binding protein
2 ZFYVE26parental protein190.070877.136FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
3 ABCB1oncoprotein21.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
4 ALAS1protein found in more fusions3021.858Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
Preseq_ALAS (PF09029, IPR015118): 5-aminolevulinate synthase presequence
5 ALDH9A1interactor100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
6 BARD1suppressor110.222299.919BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
7 BRCA2suppressor40.83317.855BRCA-2_helical (PF09169, IPR015252): BRCA2, helical
BRCA-2_OB1 (PF09103, IPR015187): BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
BRCA2 (PF00634, IPR002093): BRCA2 repeat
Tower (PF09121, IPR015205): Tower
8 CAPN1interactor60.66711.628Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
9 CAPZBinteractor40.6672.667Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit
10 CCDC33interactor70.095408.973C2 (PF00168, IPR000008, SM00239): C2 domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
11 CDK2suppressor160.362158.861Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
12 CDKN1Asuppressor70.429167.283CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
13 CEP44interactor30.33333.648DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Utp12 (PF04003, IPR007148): Dip2/Utp12 Family
CEP44 (PF15007, IPR029157): Centrosomal spindle body, CEP44
14 CHORDC1interactor90.6075.538CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
15 CRCPinteractor40.6672.000RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
16 CSE1Loncoprotein110.52729.625CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
17 CSNK2Binteractor80.6199.323CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
18 DDX18protein found in more fusions90.6118.967DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF4217 (PF13959, IPR025313, SM01178): Domain of unknown function (DUF4217)
19 DDX24interactor100.6678.652DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tti2 (PF10521, IPR018870): Tti2 family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
20 DKC1oncoprotein70.8670.786DKCLD (PF08068, IPR012960, SM01136): DKCLD (NUC011) domain
PUA (PF01472, IPR002478, SM00359): PUA domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
21 EGFRoncoprotein90.50010.948Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
22 EIF5Ainteractor60.6007.628EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
23 EIF6interactor80.53612.764eIF-6 (PF01912, IPR002769, SM00654): eIF-6 family
24 EMDinteractor70.60016.782LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
25 FAM46Ainteractor100NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
26 FTOinteractor31.0000FTO_NTD (PF12933, IPR024367): FTO catalytic domain
FTO_CTD (PF12934, IPR024366): FTO C-terminal domain
27 GDAinteractor100.60010.438Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
28 GNL3interactor90.6945.200GN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
FAM176 (PF14851): FAM176 family
29 GNSinteractor70.7622.667Sulfatase (PF00884, IPR000917): Sulfatase
DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
30 GOLGA2interactor60.333230.495ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
31 GRWD1interactor50.7001.333Voldacs (PF03517): Regulator of volume decrease after cellular swelling
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
32 HIST1H2BNinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
33 HNRNPCprotein found in more fusions80.333297.726APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
34 HNRNPUinteractor120.53065.162CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
35 ITSN2protein found in more fusions50.33319.967C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
36 KIF2Cinteractor41.0000Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
37 KRT15interactor30.6671.667Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
38 KRT40interactor40.33339.277Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
39 KRTAP10-3interactor41.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
40 KRTAP10-7interactor50.6672.000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
41 KRTAP10-9interactor41.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
42 KYNUinteractor100.6677.469Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
43 LDHAinteractor140.47450.287Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
44 LDHAL6Binteractor100.6677.836Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
45 LOC101060521interactor21.0000NA
46 MDFIinteractor3013.757MDFI (PF15316, IPR026134): MyoD family inhibitor
47 NAGKprotein found in more fusions90.8211.555BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
48 NOP9interactor30.33396.210PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
49 NPM1suppressor150.418117.293Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
50 NTRK1oncoprotein290.206730.777I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
51 PDIA3interactor80.7144.400Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
52 PEPDinteractor100.51116.250AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
53 PNMA1oncoprotein30.33365.456PNMA (PF14893, IPR026523): PNMA
54 PNMA5interactor31.0000PNMA (PF14893, IPR026523): PNMA
55 POLR1Cinteractor90.41763.180RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
56 POLR3Einteractor31.0000Sin_N (PF04801, IPR006886): Sin-like protein conserved region
DUF2382 (PF09557, IPR019060): Domain of unknown function (DUF2382)
57 PTNoncoprotein50.5005.382PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
58 RPL10suppressor80.8211.886Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
59 RPL23interactor100.44413.119Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
60 SMSinteractor120.59125.667Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
61 SORDprotein found in more fusions100.63917.529ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
62 SPAG5interactor40.16735.501CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1307 (PF06998, IPR009736): Protein of unknown function (DUF1307)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
DUF3573 (PF12097, IPR021956): Protein of unknown function (DUF3573)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4266 (PF14086, IPR025362): Domain of unknown function (DUF4266)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
63 SSX2IPprotein found in more fusions60.40024.923ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
64 TADA2Ainteractor21.0000SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
65 TCEA1oncoprotein50.8000.571Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
66 TDO2interactor200Trp_dioxygenase (PF03301, IPR004981): Tryptophan 2,3-dioxygenase
67 TENT2interactor100Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
PAP_assoc (PF03828, IPR002058): Cid1 family poly A polymerase
68 TFIP11interactor30.333170.108G-patch (PF01585, IPR000467, SM00443): G-patch domain
GCFC (PF07842, IPR022783): GC-rich sequence DNA-binding factor-like protein
TIP_N (PF12457, IPR022159): Tuftelin interacting protein N terminal
69 THOC1protein found in more fusions3070.635Death (PF00531, IPR000488, SM00005): Death domain
efThoc1 (PF11957, IPR021861): THO complex subunit 1 transcription elongation factor
70 TRAF1oncoprotein4034.931HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
71 USHBP1interactor60.200110.070DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
72 VCPprotein found in more fusions110.46724.487AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
73 YWHABinteractor70.5718.15714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

B a c k    t o    T o p ⇑