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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZFYVE26, BCCIP (from a repository: Mon Sep 9 14:36:35 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)73
The number (and %) of the onco-proteins18 (24.66 %)
The number (and %) of the tumor suppressors6 (8.22 %)
Total number of binary PPIs (saturation %)286 (10.88 %)
The number (and %) of affected PPIs71 (24.83 %)
The number of possible different fusions13
PPI diameter5
PPI radius3
The average degree of PPI7.068
Assortativity coefficient-0.0625
The network average Clustering coefficient0.507
The number (and %) of a zero Clustering coefficients9 (12.33 %)
The number (and %) of a zero Betweenness Centrality14 (19.18 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BCCIP,ZFYVE26 All fusions
Proteins found in more fusions SSX2IP (see 1 fusions); ITSN2 (see 5 fusions); ALAS1 (see 1 fusions); VCP (see 4 fusions); EGFR (see 2 fusions); NAGK (see 1 fusions); NPM1 (see 1 fusions); DDX18/DKC1 (see 1 fusions); DKC1 (see 2 fusions); SORD (see 1 fusions); THOC1 (see 2 fusions); HNRNPC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BCCIPparental protein520.1152751.793DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
BCIP (PF13862, IPR025602): p21-C-terminal region-binding protein
2 ZFYVE26parental protein190.070877.136FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
3 ABCB1oncoprotein21.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
4 ALAS1protein found in more fusions3021.858Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
Preseq_ALAS (PF09029, IPR015118): 5-aminolevulinate synthase presequence
5 ALDH9A1interactor100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
6 BARD1suppressor110.222299.919BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
7 BRCA2suppressor40.83317.855BRCA-2_helical (PF09169, IPR015252): BRCA2, helical
BRCA-2_OB1 (PF09103, IPR015187): BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
BRCA2 (PF00634, IPR002093): BRCA2 repeat
Tower (PF09121, IPR015205): Tower
8 CAPN1interactor60.66711.628Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
9 CAPZBinteractor40.6672.667Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit
10 CCDC33interactor70.095408.973C2 (PF00168, IPR000008, SM00239): C2 domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
11 CDK2suppressor160.362158.861Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
12 CDKN1Asuppressor70.429167.283CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
13 CEP44interactor30.33333.648DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Utp12 (PF04003, IPR007148): Dip2/Utp12 Family
CEP44 (PF15007, IPR029157): Centrosomal spindle body, CEP44
14 CHORDC1interactor90.6075.538CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
15 CRCPinteractor40.6672.000RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
16 CSE1Loncoprotein110.52729.625CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
17 CSNK2Binteractor80.6199.323CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
18 DDX18protein found in more fusions90.6118.967DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF4217 (PF13959, IPR025313, SM01178): Domain of unknown function (DUF4217)
19 DDX24interactor100.6678.652DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tti2 (PF10521, IPR018870): Tti2 family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
20 DKC1oncoprotein70.8670.786DKCLD (PF08068, IPR012960, SM01136): DKCLD (NUC011) domain
PUA (PF01472, IPR002478, SM00359): PUA domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
21 EGFRoncoprotein90.50010.948Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
22 EIF5Ainteractor60.6007.628EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
23 EIF6interactor80.53612.764eIF-6 (PF01912, IPR002769, SM00654): eIF-6 family
24 EMDinteractor70.60016.782LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
25 FAM46Ainteractor100NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
26 FTOinteractor31.0000FTO_NTD (PF12933, IPR024367): FTO catalytic domain
FTO_CTD (PF12934, IPR024366): FTO C-terminal domain
27 GDAinteractor100.60010.438Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
28 GNL3interactor90.6945.200GN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
FAM176 (PF14851): FAM176 family
29 GNSinteractor70.7622.667Sulfatase (PF00884, IPR000917): Sulfatase
DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
30 GOLGA2interactor60.333230.495ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
31 GRWD1interactor50.7001.333Voldacs (PF03517): Regulator of volume decrease after cellular swelling
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
32 HIST1H2BNinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
33 HNRNPCprotein found in more fusions80.333297.726APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
34 HNRNPUinteractor120.53065.162CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
35 ITSN2protein found in more fusions50.33319.967C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
36 KIF2Cinteractor41.0000Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
37 KRT15interactor30.6671.667Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
38 KRT40interactor40.33339.277Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
39 KRTAP10-3interactor41.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
40 KRTAP10-7interactor50.6672.000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
41 KRTAP10-9interactor41.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
42 KYNUinteractor100.6677.469Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
43 LDHAinteractor140.47450.287Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
44 LDHAL6Binteractor100.6677.836Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
45 LOC101060521interactor21.0000NA
46 MDFIinteractor3013.757MDFI (PF15316, IPR026134): MyoD family inhibitor
47 NAGKprotein found in more fusions90.8211.555BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
48 NOP9interactor30.33396.210PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
49 NPM1suppressor150.418117.293Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
50 NTRK1oncoprotein290.206730.777I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
51 PDIA3interactor80.7144.400Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
52 PEPDinteractor100.51116.250AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
53 PNMA1oncoprotein30.33365.456PNMA (PF14893, IPR026523): PNMA
54 PNMA5interactor31.0000PNMA (PF14893, IPR026523): PNMA
55 POLR1Cinteractor90.41763.180RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
56 POLR3Einteractor31.0000Sin_N (PF04801, IPR006886): Sin-like protein conserved region
DUF2382 (PF09557, IPR019060): Domain of unknown function (DUF2382)
57 PTNoncoprotein50.5005.382PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
58 RPL10suppressor80.8211.886Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
59 RPL23interactor100.44413.119Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
60 SMSinteractor120.59125.667Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
61 SORDprotein found in more fusions100.63917.529ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
62 SPAG5interactor40.16735.501CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1307 (PF06998, IPR009736): Protein of unknown function (DUF1307)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
DUF3573 (PF12097, IPR021956): Protein of unknown function (DUF3573)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4266 (PF14086, IPR025362): Domain of unknown function (DUF4266)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
63 SSX2IPprotein found in more fusions60.40024.923ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
64 TADA2Ainteractor21.0000SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
65 TCEA1oncoprotein50.8000.571Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
66 TDO2interactor200Trp_dioxygenase (PF03301, IPR004981): Tryptophan 2,3-dioxygenase
67 TENT2interactor100Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
PAP_assoc (PF03828, IPR002058): Cid1 family poly A polymerase
68 TFIP11interactor30.333170.108G-patch (PF01585, IPR000467, SM00443): G-patch domain
GCFC (PF07842, IPR022783): GC-rich sequence DNA-binding factor-like protein
TIP_N (PF12457, IPR022159): Tuftelin interacting protein N terminal
69 THOC1protein found in more fusions3070.635Death (PF00531, IPR000488, SM00005): Death domain
efThoc1 (PF11957, IPR021861): THO complex subunit 1 transcription elongation factor
70 TRAF1oncoprotein4034.931HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
71 USHBP1interactor60.200110.070DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
72 VCPprotein found in more fusions110.46724.487AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
73 YWHABinteractor70.5718.15714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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