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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FOLH1, PCGF5 (from a repository: Sun Oct 21 15:31:32 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins6 (18.75 %)
The number (and %) of the tumor suppressors3 (9.38 %)
Total number of binary PPIs (saturation %)131 (26.41 %)
The number (and %) of affected PPIs31 (23.66 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI7.188
Assortativity coefficient-0.3022
The network average Clustering coefficient0.545
The number (and %) of a zero Clustering coefficients7 (21.88 %)
The number (and %) of a zero Betweenness Centrality10 (31.25 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PCGF5,FOLH1 All fusions
Proteins found in more fusions CSNK2A1 (see 1 fusions); CTH (see 3 fusions); MME (see 1 fusions); RING1 (see 1 fusions); YWHAZ (see 1 fusions); BCOR (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PCGF5parental protein270.249379.727DZR (PF12773, IPR025874): Double zinc ribbon
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
2 FOLH1parental protein40119.400PA (PF02225, IPR003137): PA domain
Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
UNC-79 (PF14776): Cation-channel complex subunit UNC-79
3 AUTS2interactor90.8611.358SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SPX (PF03105, IPR004331): SPX domain
Auts2 (PF15336): Autism susceptibility gene 2 protein
4 BCORoncoprotein80.8570.841Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
5 CBX6interactor51.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
CBX7_C (PF17218): CBX family C-terminal motif
6 CBX7interactor80.7505.628Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
CBX7_C (PF17218): CBX family C-terminal motif
7 CBX8interactor90.6797.626Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
8 CSNK2A1oncoprotein160.467176.762Pkinase (PF00069, IPR000719): Protein kinase domain
9 CSNK2A2interactor110.7455.394Pkinase (PF00069, IPR000719): Protein kinase domain
10 CSNK2Binteractor120.54521.034CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
11 CTHprotein found in more fusions200Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
12 FBRSinteractor80.8571.091CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Auts2 (PF15336): Autism susceptibility gene 2 protein
13 FBRSL1interactor50.9000.250DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Auts2 (PF15336): Autism susceptibility gene 2 protein
14 KIF2Cinteractor31.0000Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
15 MMEsuppressor3047.045Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
16 MTAPsuppressor100PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
17 NLRP3oncoprotein100NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
FISNA (PF14484, IPR029495): Fish-specific NACHT associated domain
18 PCGF1interactor120.6009.060zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
19 PHC2interactor90.7862.286SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
20 PLK2suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
21 POLKinteractor100ATP-cone (PF03477, IPR005144): ATP cone domain
IMS (PF00817, IPR001126): impB/mucB/samB family
IMS_HHH (PF11798, IPR024728): IMS family HHH motif
IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain
22 PRMT6interactor100Methyltransf_25 (PF13649): Methyltransferase domain
23 RING1protein found in more fusions160.52429.347zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
24 RNF2interactor200.45063.598zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
25 RPS3interactor40.167116.922KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
26 RYBPinteractor110.63610.745DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
27 TRAF2interactor50.50021.907MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
28 TRIM8interactor31.0000dCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
29 UBE2D3interactor70.6678.688UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
30 XPO1interactor110.43677.699CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
31 YAF2interactor90.7505.593DUF460 (PF04312, IPR007408): Protein of unknown function (DUF460)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Exo5 (PF09810, IPR019190): Exonuclease V - a 5' deoxyribonuclease
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
YAF2_RYBP (PF17219): Yaf2/RYBP C-terminal binding motif
32 YWHAZprotein found in more fusions31.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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