Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins FOLH1, PCGF5 (from a repository: Sun Oct 21 15:31:32 2018)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 32 The number (and %) of the onco-proteins 6 (18.75 %) The number (and %) of the tumor suppressors 3 (9.38 %) Total number of binary PPIs (saturation %) 131 (26.41 %) The number (and %) of affected PPIs 31 (23.66 %) The number of possible different fusions 7 PPI diameter 5 PPI radius 3 The average degree of PPI 7.188 Assortativity coefficient -0.3022 The network average Clustering coefficient 0.545 The number (and %) of a zero Clustering coefficients 7 (21.88 %) The number (and %) of a zero Betweenness Centrality 10 (31.25 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PCGF5,FOLH1	All fusions
Proteins found in more fusions	CSNK2A1 (see 1 fusions); CTH (see 3 fusions); MME (see 1 fusions); RING1 (see 1 fusions); YWHAZ (see 1 fusions); BCOR (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PCGF5	parental protein	27	0.249	379.727	DZR (PF12773, IPR025874): Double zinc ribbon zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
2	FOLH1	parental protein	4	0	119.400	PA (PF02225, IPR003137): PA domain Peptidase_M28 (PF04389, IPR007484): Peptidase family M28 TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain UNC-79 (PF14776): Cation-channel complex subunit UNC-79
3	AUTS2	interactor	9	0.861	1.358	SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SPX (PF03105, IPR004331): SPX domain Auts2 (PF15336): Autism susceptibility gene 2 protein
4	BCOR	oncoprotein	8	0.857	0.841	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
5	CBX6	interactor	5	1.000	0	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain CBX7_C (PF17218): CBX family C-terminal motif
6	CBX7	interactor	8	0.750	5.628	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain CBX7_C (PF17218): CBX family C-terminal motif
7	CBX8	interactor	9	0.679	7.626	Atrophin-1 (PF03154, IPR002951): Atrophin-1 family Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain RBR (PF17208): RNA binding Region CBX7_C (PF17218): CBX family C-terminal motif
8	CSNK2A1	oncoprotein	16	0.467	176.762	Pkinase (PF00069, IPR000719): Protein kinase domain
9	CSNK2A2	interactor	11	0.745	5.394	Pkinase (PF00069, IPR000719): Protein kinase domain
10	CSNK2B	interactor	12	0.545	21.034	CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
11	CTH	protein found in more fusions	2	0	0	Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
12	FBRS	interactor	8	0.857	1.091	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Auts2 (PF15336): Autism susceptibility gene 2 protein
13	FBRSL1	interactor	5	0.900	0.250	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) Auts2 (PF15336): Autism susceptibility gene 2 protein
14	KIF2C	interactor	3	1.000	0	Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
15	MME	suppressor	3	0	47.045	Peptidase_M13 (PF01431, IPR018497): Peptidase family M13 Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
16	MTAP	suppressor	1	0	0	PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
17	NLRP3	oncoprotein	1	0	0	NACHT (PF05729): NACHT domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat FISNA (PF14484, IPR029495): Fish-specific NACHT associated domain
18	PCGF1	interactor	12	0.600	9.060	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
19	PHC2	interactor	9	0.786	2.286	SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit zf-CGNR (PF11706, IPR021005): CGNR zinc finger DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692) PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
20	PLK2	suppressor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain POLO_box (PF00659, IPR000959): POLO box duplicated region G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
21	POLK	interactor	1	0	0	ATP-cone (PF03477, IPR005144): ATP cone domain IMS (PF00817, IPR001126): impB/mucB/samB family IMS_HHH (PF11798, IPR024728): IMS family HHH motif IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain
22	PRMT6	interactor	1	0	0	Methyltransf_25 (PF13649): Methyltransferase domain
23	RING1	protein found in more fusions	16	0.524	29.347	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
24	RNF2	interactor	20	0.450	63.598	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
25	RPS3	interactor	4	0.167	116.922	KH_2 (PF07650, IPR004044): KH domain Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
26	RYBP	interactor	11	0.636	10.745	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
27	TRAF2	interactor	5	0.500	21.907	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
28	TRIM8	interactor	3	1.000	0	dCache_2 (PF08269, IPR004010, SM01049): Cache domain CASP_C (PF08172, IPR012955): CASP C terminal zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
29	UBE2D3	interactor	7	0.667	8.688	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
30	XPO1	interactor	11	0.436	77.699	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
31	YAF2	interactor	9	0.750	5.593	DUF460 (PF04312, IPR007408): Protein of unknown function (DUF460) OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Exo5 (PF09810, IPR019190): Exonuclease V - a 5' deoxyribonuclease zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein YAF2_RYBP (PF17219): Yaf2/RYBP C-terminal binding motif
32	YWHAZ	protein found in more fusions	3	1.000	0	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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