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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FOLH1, FMNL2 (from a repository: Fri Aug 2 01:19:25 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins7 (46.67 %)
The number (and %) of the tumor suppressors2 (13.33 %)
Total number of binary PPIs (saturation %)28 (26.67 %)
The number (and %) of affected PPIs13 (46.43 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI2.800
Assortativity coefficient-0.1974
The network average Clustering coefficient0.380
The number (and %) of a zero Clustering coefficients7 (46.67 %)
The number (and %) of a zero Betweenness Centrality9 (60.00 %)


List of the fusions

PPI for parental proteins: FMNL2,FOLH1 All fusions
Proteins found in more fusions MME (see 1 fusions); APP (see 5 fusions); GRK5 (see 2 fusions); PRPF40A (see 2 fusions); CTH (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 FMNL2parental protein90.19495.000Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
2 FOLH1parental protein4072.000PA (PF02225, IPR003137): PA domain
Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
UNC-79 (PF14776): Cation-channel complex subunit UNC-79
3 APPprotein found in more fusions31.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 CDC42oncoprotein200Ras (PF00071, IPR001806, SM00173): Ras family
5 CIAO1interactor40.6672.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6 CTHprotein found in more fusions200Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
7 FAM96Binteractor31.0000DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
8 GRK5protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
9 MMEsuppressor200Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
10 MMS19interactor50.50020.000DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
11 MTAPsuppressor100PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
12 NTRK1oncoprotein50.33391.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
13 PNMA1oncoprotein100PNMA (PF14893, IPR026523): PNMA
14 PRPF40Aprotein found in more fusions31.0000FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
15 RPS3interactor2080.000KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain

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