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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DOCK9, DPP4 (from a repository: Sat Aug 10 15:01:18 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins6 (42.86 %)
The number (and %) of the tumor suppressors3 (21.43 %)
Total number of binary PPIs (saturation %)23 (25.27 %)
The number (and %) of affected PPIs12 (52.17 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI2.286
Assortativity coefficient-0.0614
The network average Clustering coefficient0.494
The number (and %) of a zero Clustering coefficients5 (35.71 %)
The number (and %) of a zero Betweenness Centrality11 (78.57 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DOCK9,DPP4 All fusions
Proteins found in more fusions IKBKB (see 2 fusions); SMAD3 (see 3 fusions); SMAD2 (see 2 fusions); LNX1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DOCK9parental protein50.10018.000DHR-2 (PF06920, IPR010703): Dock homology region 2
PH (PF00169, IPR001849, SM00233): PH domain
DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
2 DPP4parental protein70.14335.000DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
3 ADAinteractor21.0000A_deaminase (PF00962, IPR001365): Adenosine/AMP deaminase
4 BCL10suppressor40.6671.000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
5 CARD11oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
6 CCL22interactor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
7 CDC42oncoprotein200Ras (PF00071, IPR001806, SM00173): Ras family
8 CUL4Boncoprotein100Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
9 DKK1suppressor100Dickkopf_N (PF04706, IPR006796): Dickkopf N-terminal cysteine-rich region
UPF0506 (PF11703, IPR021712): UPF0506
10 FAPinteractor21.0000DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
11 IKBKBprotein found in more fusions31.0000FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
12 LNX1protein found in more fusions200PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
13 SMAD2suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
14 SMAD3oncoprotein31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain

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