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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TTC28, C3orf14 (from a repository: Fri Jul 26 01:10:32 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins5 (23.81 %)
The number (and %) of the tumor suppressors1 (4.76 %)
Total number of binary PPIs (saturation %)48 (22.86 %)
The number (and %) of affected PPIs19 (39.58 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI4.000
Assortativity coefficient-0.3585
The network average Clustering coefficient0.461
The number (and %) of a zero Clustering coefficients6 (28.57 %)
The number (and %) of a zero Betweenness Centrality9 (42.86 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TTC28,C3orf14 All fusions
Proteins found in more fusions HLA-B (see 4 fusions); NIN (see 1 fusions); TP53 (see 3 fusions); UBC (see 7 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TTC28parental protein180.137261.500HisKA_3 (PF07730, IPR011712): Histidine kinase
PUB (PF09409, IPR018997): PUB domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
CHAT (PF12770, IPR024983): CHAT domain
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
2 C3orf14parental protein100DUF4570 (PF15134, IPR028006): Domain of unknown function (DUF4570)
3 BREoncoprotein31.0000BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
4 BSGinteractor21.0000Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
5 CEP120interactor40.8330.500C2 (PF00168, IPR000008, SM00239): C2 domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
DUF3668 (PF12416, IPR022136): Cep120 protein
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
6 CEP152interactor50.7001.833bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
FAD-SLDH (PF12318, IPR024651): Membrane bound FAD containing D-sorbitol dehydrogenase
YtxH (PF12732, IPR024623): YtxH-like protein
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
7 CEP89interactor3038.667ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
8 HLA-Boncoprotein200MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
9 MED23interactor30.6672.333Med23 (PF11573, IPR021629): Mediator complex subunit 23
10 MED4interactor70.33346.333Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
11 NCK2interactor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
12 NINoncoprotein40.6670.500BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DivIVA (PF05103, IPR007793): DivIVA protein
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Rho_Binding (PF08912, IPR015008): Rho Binding
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
13 NINLinteractor40.33329.333PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
14 NTRK1oncoprotein60.5005.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
15 PRMT2interactor100PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
16 SASS6interactor40.6671.333CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
SAS-6_N (PF16531, IPR032396): Centriolar protein SAS N-terminal
17 SDF4interactor100Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
18 SSPOinteractor100C8 (PF08742, IPR014853, SM00832): C8 domain
Pacifastin_I (PF05375, IPR008037): Pacifastin inhibitor (LCMII)
TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
19 TP53suppressor80.38114.667DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
20 UBCprotein found in more fusions70.4678.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
21 YWHABinteractor31.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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