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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)124
The number (and %) of the onco-proteins30 (24.19 %)
The number (and %) of the tumor suppressors26 (20.97 %)
Total number of binary PPIs (saturation %)579 (7.59 %)
The number (and %) of affected PPIs123 (21.24 %)
The number of possible different fusions21
PPI diameter4
PPI radius2
The average degree of PPI8.597
Assortativity coefficient-0.3421
The network average Clustering coefficient0.552
The number (and %) of a zero Clustering coefficients18 (14.52 %)
The number (and %) of a zero Betweenness Centrality49 (39.52 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAN2B2,TP63 All fusions
Proteins found in more fusions VCP (see 4 fusions); EEF1A1 (see 1 fusions); HIPK2 (see 1 fusions); HSP90AB1 (see 1 fusions); A2M (see 2 fusions); NFKB1 (see 2 fusions); EEF1A1/RPL12 (see 1 fusions); HNRNPA3/NONO (see 1 fusions); WWP1 (see 1 fusions); MDM4 (see 2 fusions); HNRNPL (see 2 fusions); KAT2B (see 1 fusions); RACK1 (see 3 fusions); TRAPPC11 (see 1 fusions); IKBKB (see 2 fusions); EP300 (see 1 fusions); ATP5A1 (see 1 fusions); PML (see 4 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAN2B2parental protein31.0000Alpha-mann_mid (PF09261, IPR015341, SM00872): Alpha mannosidase middle domain
Glyco_hydro_38 (PF01074, IPR000602): Glycosyl hydrolases family 38 N-terminal domain
Glyco_hydro_38C (PF07748, IPR011682): Glycosyl hydrolases family 38 C-terminal domain
2 TP63parental protein1200.05610603.065Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
3 A2Mprotein found in more fusions50.66723.355A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
4 ADH5interactor31.0000ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
5 AGBL2interactor21.0000Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
6 AGO1interactor40.8330.400ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
7 AGO2interactor50.6001.972ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
8 ASPMoncoprotein21.0000CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RST (PF12174, IPR022003): RCD1-SRO-TAF4 (RST) plant domain
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
9 ATP5A1protein found in more fusions80.71430.999ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
10 BAG6interactor90.4299.756DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
11 BRCA1suppressor190.29473.288BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
12 BRD8interactor21.0000Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
13 BTRConcoprotein210.35373.131WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
14 CADoncoprotein90.50042.577Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain
CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
MGS (PF02142, IPR011607, SM00851): MGS-like domain
OTCace (PF00185, IPR006131): Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
OTCace_N (PF02729, IPR006132): Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
ATPgrasp_Ter (PF15632, IPR011226): ATP-grasp in the biosynthetic pathway with Ter operon
15 CARM1oncoprotein100.6225.730K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain
CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
16 CCNCsuppressor21.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
17 CCT8interactor70.66731.483Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18 CDKN1Asuppressor190.31679.927CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
19 CDKN2Asuppressor150.40034.920Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
20 CDT1oncoprotein31.0000CDT1 (PF08839, IPR014939, SM01075): DNA replication factor CDT1 like
CDT1_C (PF16679, IPR032054): DNA replication factor Cdt1 C-terminal domain
21 CEBPBoncoprotein110.5786.681RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
22 CENPEinteractor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
VIT1 (PF01988, IPR008217): VIT family
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fez1 (PF06818): Fez1
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pepsin-I3 (PF06394, IPR010480): Pepsin inhibitor-3-like repeated domain
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TrbI_Ftype (PF09677, IPR014115): Type-F conjugative transfer system protein (TrbI_Ftype)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
AAA_13 (PF13166, IPR026866): AAA domain
DUF4023 (PF13215, IPR025097): Protein of unknown function (DUF4023)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
23 CEP83interactor200ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Wzz (PF02706, IPR003856): Chain length determinant protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
24 CHUKsuppressor100.7502.770Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
25 COPS6interactor160.29590.376DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
26 CPSF6interactor70.5248.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
27 DAB2IPsuppressor30.6670.500C2 (PF00168, IPR000008, SM00239): C2 domain
PH_2 (PF08458, IPR013666): Plant pleckstrin homology-like region
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
DUF3498 (PF12004, IPR021887): Domain of unknown function (DUF3498)
28 DAXXoncoprotein120.6368.277Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
29 DDX23interactor30.6670.667DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Transformer (PF06495, IPR010519): Fruit fly transformer protein
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3698 (PF12479, IPR022167): Protein of unknown function (DUF3698)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
30 DHX9oncoprotein120.40965.392DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
31 DNAJB6interactor21.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
32 DPH1suppressor40.6670.952Diphthamide_syn (PF01866, IPR002728): Putative diphthamide synthesis protein
33 EEF1A1suppressor210.347127.688GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
34 EMX1interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
35 EP300oncoprotein260.303139.927Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
36 ETV4oncoprotein21.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
37 FASsuppressor90.4649.034Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
38 FBXO6interactor210.186786.777FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
39 FBXW7suppressor90.28619.043Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
40 FLNCinteractor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
41 FUSsuppressor200.25897.342Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
42 GAS8interactor100Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Tup_N (PF08581, IPR013890): Tup N-terminal
DUF3332 (PF11810, IPR021768): Domain of unknown function (DUF3332)
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
43 GCGRinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
44 GOLGA4interactor100ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fez1 (PF06818): Fez1
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
GRIP (PF01465, IPR000237, SM00755): GRIP domain
Mnd1 (PF03962, IPR005647): Mnd1 family
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
XhlA (PF10779, IPR019715): Haemolysin XhlA
YlqD (PF11068, IPR021297): YlqD protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
TetR_C_13 (PF16925, IPR011075): Bacterial transcriptional repressor C-terminal
45 HIPK2suppressor130.54519.384Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
46 HIST1H1Dinteractor40.33327.481Stm1_N (PF09598, IPR019084): Stm1
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
47 HNRNPA3oncoprotein100.5789.292IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
48 HNRNPABinteractor60.7331.139CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
GRP (PF07172, IPR010800): Glycine rich protein family
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462)
49 HNRNPCL1interactor21.0000FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
XhlA (PF10779, IPR019715): Haemolysin XhlA
50 HNRNPKoncoprotein220.357146.778ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
51 HNRNPLprotein found in more fusions120.56449.254RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
52 HNRNPRinteractor90.55640.340RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
53 HPinteractor21.0000Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
54 HPXinteractor100Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
55 HSP90AB1oncoprotein160.41983.256HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
56 HSPA5oncoprotein230.290150.944HSP70 (PF00012, IPR013126): Hsp70 protein
57 IGF2BP1oncoprotein70.47638.325RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
MOEP19 (PF16005, IPR031952): KH-like RNA-binding domain
58 IKBKBprotein found in more fusions110.53314.197FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
59 ITCHinteractor120.40021.502C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
60 ITIH4interactor100ITI_HC_C (PF06668, IPR010600): Inter-alpha-trypsin inhibitor heavy chain C-terminus
VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
61 JPH1interactor100MORN (PF02493, IPR003409, SM00698): MORN repeat
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
62 KAT2Bprotein found in more fusions100.6396.058Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
63 KRT5interactor30.6670.286Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
64 KRT6Cinteractor100Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
65 LOC613037interactor21.0000NPIP (PF06409): Nuclear pore complex interacting protein (NPIP)
ACC_epsilon (PF13822, IPR032716): Acyl-CoA carboxylase epsilon subunit
DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632)
66 MAP1Ainteractor21.0000Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
67 MDM2oncoprotein270.332112.879Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
68 MDM4oncoprotein110.5788.717zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
69 MTHFSDinteractor21.00005-FTHF_cyc-lig (PF01812, IPR002698): 5-formyltetrahydrofolate cyclo-ligase family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
70 MYL9interactor21.0000UPF0154 (PF03672, IPR005359): Uncharacterised protein family (UPF0154)
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
71 MYLPFinteractor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
72 N4BP2interactor31.0000CUE (PF02845, IPR003892, SM00546): CUE domain
DUF1771 (PF08590, IPR013899, SM01162): Domain of unknown function (DUF1771)
RyR (PF02026, IPR003032): RyR domain
Smr (PF01713, IPR002625, SM00463): Smr domain
AAA_22 (PF13401, IPR003593): AAA domain
AAA_33 (PF13671): AAA domain
73 NAAAinteractor31.0000CBAH (PF02275, IPR003199): Linear amide C-N hydrolases, choloylglycine hydrolase family
NAAA-beta (PF15508, IPR029130): beta subunit of N-acylethanolamine-hydrolyzing acid amidase
74 NFKB1suppressor130.47016.524Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
75 NFYAinteractor41.0000CBFB_NFYA (PF02045, IPR001289): CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
MSP1_C (PF07462, IPR010901): Merozoite surface protein 1 (MSP1) C-terminus
FixG_C (PF11614, IPR032879): IG-like fold at C-terminal of FixG, putative oxidoreductase
DUF4237 (PF14021, IPR025331): Protein of unknown function (DUF4237)
76 NIPSNAP3Ainteractor100NIPSNAP (PF07978, IPR012577): NIPSNAP
77 NONOoncoprotein90.5007.919GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PAS_7 (PF12860): PAS fold
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
78 NPRL3interactor21.0000NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
79 ORM1interactor100Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
80 PINX1suppressor100G-patch (PF01585, IPR000467, SM00443): G-patch domain
NR_Repeat (PF14046, IPR025900): Nuclear receptor repeat
81 PIWIL1interactor21.0000ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
GAGE (PF05831, IPR008625): GAGE protein
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
82 PLS3interactor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
83 PMLsuppressor150.48424.837zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
84 PSMD2oncoprotein70.4766.514PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
85 RACK1suppressor120.40054.453WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
86 RBL2suppressor40.5000.936CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pap_E4 (PF02711, IPR003861): E4 protein
RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
SLH (PF00395, IPR001119): S-layer homology domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
87 RCHY1suppressor51.0000C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
88 RELAoncoprotein200.38057.427DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
89 RNF144Binteractor30.6670.333IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
90 RNF38interactor31.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
91 RPL12protein found in more fusions100.6896.116Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
92 RPL13Ainteractor61.0000Ribosomal_L13 (PF00572, IPR005822): Ribosomal protein L13
93 RPL24interactor120.54515.475MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
94 RPL3interactor110.6558.198Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
95 RPLP0interactor110.6558.365Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
96 RPSAinteractor140.47324.671Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
97 S1PR5interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7tm_4 (PF13853): Olfactory receptor
98 SACSinteractor21.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
HEPN (PF05168, IPR007842, SM00748): HEPN domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
DUF4368 (PF14287, IPR025378): Domain of unknown function (DUF4368)
ThaI (PF15514, IPR029128): Restriction endonuclease ThaI
99 SAFBsuppressor30.6670.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
100 SCAF4interactor21.0000CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
101 SEC24Cinteractor21.0000Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
102 SFNsuppressor150.35237.69814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
103 SIAEinteractor31.0000SASA (PF03629, IPR005181): Carbohydrate esterase, sialic acid-specific acetylesterase
104 SLC35A3interactor100Nuc_sug_transp (PF04142, IPR007271): Nucleotide-sugar transporter
105 SMAD3oncoprotein210.33778.886MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
106 SMARCD2interactor40.6672.000SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
107 SNRPAinteractor70.5333.448RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
108 STK11suppressor30.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
109 SUMO1interactor140.52619.532Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
110 SYNCRIPinteractor150.32484.964RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
111 TP53suppressor620.1191438.322DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
112 TRAPPC11protein found in more fusions31.0000DUF974 (PF06159, IPR010378): Protein of unknown function (DUF974)
Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1
Gryzun-like (PF12742, IPR025876): Gryzun, putative Golgi trafficking
113 TRMT11interactor21.0000N6_N4_Mtase (PF01555, IPR002941): DNA methylase
UPF0020 (PF01170, IPR000241): Putative RNA methylase family UPF0020
114 TUBA1Cinteractor130.47458.137Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
115 UACAinteractor40.6671.500APG6 (PF04111, IPR007243): Autophagy protein Apg6
DivIC (PF04977, IPR007060): Septum formation initiator
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
MAD (PF05557, IPR008672): Mitotic checkpoint protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
SHE3 (PF17078, IPR031398): SWI5-dependent HO expression protein 3
116 UBE2Iinteractor190.39256.263UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
117 UBE4Bsuppressor70.8670.583DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
118 UPF2interactor50.5003.000DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
119 VCPprotein found in more fusions190.373101.612AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
120 WWOXsuppressor170.29479.347adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
121 WWP1oncoprotein50.8330.667C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
122 YAP1suppressor80.4646.915Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
123 ZBTB4suppressor21.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
SPX (PF03105, IPR004331): SPX domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
124 ZNF676interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
zf-trcl (PF13451, IPR025306): Probable zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zinc_ribbon_5 (PF13719, IPR011723): zinc-ribbon domain

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