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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAN2B2, MUC5B (from a repository: Wed Feb 21 06:07:40 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins1 (8.33 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)15 (22.73 %)
The number (and %) of affected PPIs10 (66.67 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI2.167
Assortativity coefficient-1.0000
The network average Clustering coefficient0.333
The number (and %) of a zero Clustering coefficients8 (66.67 %)
The number (and %) of a zero Betweenness Centrality11 (91.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAN2B2,MUC5B All fusions
Proteins found in more fusions UBC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAN2B2parental protein31.0000Alpha-mann_mid (PF09261, IPR015341, SM00872): Alpha mannosidase middle domain
Glyco_hydro_38 (PF01074, IPR000602): Glycosyl hydrolases family 38 N-terminal domain
Glyco_hydro_38C (PF07748, IPR011682): Glycosyl hydrolases family 38 C-terminal domain
2 MUC5Bparental protein7042.000Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
C8 (PF08742, IPR014853, SM00832): C8 domain
Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
Pro_Al_protease (PF02983, IPR004236): Alpha-lytic protease prodomain
TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
Mucin2_WxxW (PF13330, IPR025155): Mucin-2 protein WxxW repeating region
3 AMY1Ainteractor100Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain
Alpha-amylase_C (PF02806, IPR006048, SM00632): Alpha amylase, C-terminal all-beta domain
4 C7orf25interactor100DUF1308 (PF07000, IPR010733): Protein of unknown function (DUF1308)
DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
5 FBXO6interactor31.0000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
6 HTN1interactor100Fungus-induced (PF10917, IPR024415): Fungus-induced protein
7 ICE2interactor100NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
8 KIR2DS2interactor200ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
9 NAAAinteractor31.0000CBAH (PF02275, IPR003199): Linear amide C-N hydrolases, choloylglycine hydrolase family
NAAA-beta (PF15508, IPR029130): beta subunit of N-acylethanolamine-hydrolyzing acid amidase
10 SIAEinteractor31.0000SASA (PF03629, IPR005181): Carbohydrate esterase, sialic acid-specific acetylesterase
11 STATHinteractor100Statherin (PF03875, IPR005575): Statherin
12 UBCprotein found in more fusions200ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

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