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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KIAA1217, ANKS1A (from a repository: Wed Jan 25 06:29:14 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)47
The number (and %) of the onco-proteins11 (23.40 %)
The number (and %) of the tumor suppressors8 (17.02 %)
Total number of binary PPIs (saturation %)116 (10.73 %)
The number (and %) of affected PPIs45 (38.79 %)
The number of possible different fusions9
PPI diameter5
PPI radius3
The average degree of PPI4.128
Assortativity coefficient-0.2783
The network average Clustering coefficient0.409
The number (and %) of a zero Clustering coefficients15 (31.91 %)
The number (and %) of a zero Betweenness Centrality22 (46.81 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ANKS1A,KIAA1217 All fusions
Proteins found in more fusions PACSIN2 (see 1 fusions); HSBP1 (see 1 fusions); EGFR (see 2 fusions); UBC (see 1 fusions); SIAH1 (see 4 fusions); HNRNPLL (see 1 fusions); YWHAG (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ANKS1Aparental protein230.091910.720PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
2 KIAA1217parental protein220.061765.319AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
3 ABI2suppressor60.40019.777Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
4 ARHGAP10interactor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
BAR_3 (PF16746): BAR domain of APPL family
5 BAG3oncoprotein60.30096.904BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
6 CNTROBinteractor21.0000DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
FadA (PF09403, IPR018543): Adhesion protein FadA
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
7 DEF6interactor100ArgK (PF03308, IPR005129): ArgK protein
HSP70 (PF00012, IPR013126): Hsp70 protein
PH (PF00169, IPR001849, SM00233): PH domain
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
8 DNPEPinteractor41.0000Peptidase_M18 (PF02127, IPR001948): Aminopeptidase I zinc metalloprotease (M18)
9 DOK3suppressor2024.429IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
10 EGFRoncoprotein110.289213.183Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
11 EPHA8interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
12 ERBB2oncoprotein70.467103.360Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
13 ERBB4suppressor41.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 EXOSC5interactor31.0000RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
15 FHL2oncoprotein3017.205LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
16 FXR2interactor31.0000Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
17 GCC1interactor50.30066.107DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
GRIP (PF01465, IPR000237, SM00755): GRIP domain
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
FAM184 (PF15665): Family with sequence similarity 184, A and B
18 GOLGA2interactor50.6005.952ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
19 HNRNPLLprotein found in more fusions200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
20 HSBP1protein found in more fusions200HSBP1 (PF06825, IPR009643): Heat shock factor binding protein 1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
21 KLF15interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
22 KRT15interactor30.33328.434Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
23 MICU2interactor10023S_rRNA_IVP (PF05635, IPR012657): 23S rRNA-intervening sequence protein
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
24 NARSinteractor2017.205tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
25 NCK2interactor70.267172.044SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
26 NHLRC2interactor100NHL (PF01436, IPR001258): NHL repeat
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Thioredoxin_8 (PF13905, IPR012336): Thioredoxin-like
27 NINLinteractor21.0000PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
28 PACSIN2oncoprotein31.0000DegS (PF05384, IPR008595): Sensor protein DegS
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
SH3BP5 (PF05276, IPR007940): SH3 domain-binding protein 5 (SH3BP5)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
29 PIK3R3interactor50.50021.652SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
30 PTPN12suppressor50.50019.675Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PTPlike_phytase (PF14566): Inositol hexakisphosphate
ER-remodelling (PF14755, IPR032786): Intracellular membrane remodeller
31 RANBP3oncoprotein30.33335.105Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
32 RB1suppressor21.0000RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
33 SEC16Ainteractor40.50033.800APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
34 SFNsuppressor40.6670.40014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
35 SHMT2interactor21.0000SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
36 SIAH1suppressor200Sina (PF03145, IPR018121): Seven in absentia protein family
37 SMARCD1interactor50.200140.760ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
DivIC (PF04977, IPR007060): Septum formation initiator
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
38 SORBS3interactor3024.576Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
39 TEX11interactor100SPO22 (PF08631, IPR013940): Meiosis protein SPO22/ZIP4 like
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2547 (PF10818, IPR020508): Protein of unknown function (DUF2547)
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
AAA_28 (PF13521): AAA domain
TPR_19 (PF14559): Tetratricopeptide repeat
40 TRAF1oncoprotein4063.267HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
41 TRIM47interactor31.0000Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
42 TRIT1suppressor100IPPT (PF01715, IPR002627): IPP transferase
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
43 UBCprotein found in more fusions90.214186.055ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
44 VPS52interactor31.0000Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
45 XPO1interactor100.178321.823CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
46 YWHABinteractor50.7004.70814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
47 YWHAGprotein found in more fusions80.33377.53814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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