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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KCTD21, WWC1 (from a repository: Mon Aug 5 13:31:50 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)43
The number (and %) of the onco-proteins10 (23.26 %)
The number (and %) of the tumor suppressors6 (13.95 %)
Total number of binary PPIs (saturation %)181 (20.04 %)
The number (and %) of affected PPIs41 (22.65 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI7.442
Assortativity coefficient-0.0580
The network average Clustering coefficient0.496
The number (and %) of a zero Clustering coefficients3 (6.98 %)
The number (and %) of a zero Betweenness Centrality7 (16.28 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KCTD21,WWC1 All fusions
Proteins found in more fusions NF2 (see 1 fusions); WWC2 (see 1 fusions); CUL3 (see 1 fusions); YWHAG (see 1 fusions); YWHAH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KCTD21parental protein40.167162.000BTB_2 (PF02214, IPR003131): BTB/POZ domain
PH_3 (PF14593): PH domain
2 WWC1parental protein370.161820.365APG6 (PF04111, IPR007243): Autophagy protein Apg6
bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
WW (PF00397, IPR001202, SM00456): WW domain
3 AMOToncoprotein100.44453.891FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family
DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162)
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
4 ARRDC1interactor21.0000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 ATAD3Ainteractor40.3339.753AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
6 BTRConcoprotein90.5368.367WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
7 CDC5Linteractor90.53633.586OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
8 CDC73suppressor50.5003.167CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
9 CUL3protein found in more fusions140.192333.533Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10 DLC1suppressor40.50020.157RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
START (PF01852, IPR002913, SM00234): START domain
DUF4561 (PF15120, IPR027818): Domain of unknown function (DUF4561)
11 DNAJB11interactor21.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
12 DOC2Ainteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
13 DYNLL1interactor70.4676.000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
14 DYNLL2interactor50.6672.000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
15 EPB41L2interactor41.00004_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DUF966 (PF06136, IPR010369): Domain of unknown function (DUF966)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
SAB (PF04382, IPR007477): SAB domain
TCP (PF03634, IPR005333): TCP family transcription factor
16 EPB41L3suppressor100.53313.8334_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
17 FBXW11interactor80.6195.400WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
18 FEZ1interactor50.6672.000FEZ (PF07763, IPR011680): FEZ-like protein
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
19 FEZ2interactor40.6672.000FEZ (PF07763, IPR011680): FEZ-like protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
20 HIST1H3Ainteractor80.47611.476Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
21 KLHL14interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
22 KRASoncoprotein90.35717.025Ras (PF00071, IPR001806, SM00173): Ras family
23 LATS1suppressor70.7143.167Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
24 LATS2suppressor100.52810.200Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
25 LRIF1interactor40.6671.000LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
26 MAPK6oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
27 MOV10interactor60.40018.324AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
28 NF2suppressor100.38917.300ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
29 NXF1interactor80.38132.516NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
30 PARD6Binteractor50.7001.467PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
31 PRKCAinteractor90.39312.433C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
32 PRKCZinteractor100.47221.567PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
33 PTPN14oncoprotein80.4649.900FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
34 TNIKinteractor21.0000CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499)
CNDH2_M (PF16869): PF16858
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
35 TUBGCP4interactor40.5001.833Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
36 WWC2protein found in more fusions100.41714.700DASH_Dad2 (PF08654, IPR013963): DASH complex subunit Dad2
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Phage_Nu1 (PF07471, IPR010906): Phage DNA packaging protein Nu1
WW (PF00397, IPR001202, SM00456): WW domain
37 WWC3interactor70.6672.900APG6 (PF04111, IPR007243): Autophagy protein Apg6
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
IncA (PF04156, IPR007285): IncA protein
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
MDMPI_N (PF11716, IPR024344): Mycothiol maleylpyruvate isomerase N-terminal domain
DUF4452 (PF14618, IPR027915): Domain of unknown function (DUF4452)
LURAP (PF14854): Leucine rich adaptor protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
38 XPO1interactor100.31130.967CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
39 YWHABinteractor120.53035.02514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
40 YWHAEoncoprotein130.50039.13414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
41 YWHAGprotein found in more fusions180.37583.69214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
42 YWHAHprotein found in more fusions120.56432.41114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
43 YWHAQinteractor120.53040.91114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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