Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins DRG1, ANKRD28 (from a repository: Wed Jan 20 19:41:42 2021)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 116 The number (and %) of the onco-proteins 25 (21.55 %) The number (and %) of the tumor suppressors 15 (12.93 %) Total number of binary PPIs (saturation %) 560 (8.40 %) The number (and %) of affected PPIs 116 (20.71 %) The number of possible different fusions 13 PPI diameter 4 PPI radius 2 The average degree of PPI 9.017 Assortativity coefficient -0.2737 The network average Clustering coefficient 0.358 The number (and %) of a zero Clustering coefficients 17 (14.66 %) The number (and %) of a zero Betweenness Centrality 18 (15.52 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ANKRD28,DRG1	All fusions
Proteins found in more fusions	AP2M1 (see 3 fusions); MAGED1 (see 1 fusions); STAU1 (see 2 fusions); CUL7 (see 2 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); UBR5 (see 4 fusions); APC (see 1 fusions); USP10 (see 1 fusions); EPS8 (see 1 fusions); TGM2 (see 4 fusions); SNW1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ANKRD28	parental protein	73	0.066	5352.919	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
2	DRG1	parental protein	43	0.099	2393.734	MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase TGS (PF02824, IPR004095): TGS domain MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain
3	ABL1	oncoprotein	10	0.389	29.497	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4	ACACB	interactor	1	0	0	ACC_central (PF08326, IPR013537): Acetyl-CoA carboxylase, central region Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
5	AGPAT2	interactor	1	0	0	Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
6	AKAP8L	interactor	7	0.476	25.777	AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
7	ANKRD44	oncoprotein	11	0.545	41.416	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
8	AP2M1	protein found in more fusions	13	0.364	91.928	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
9	APC	suppressor	10	0.333	65.477	APC_15aa (PF05972, IPR009240): APC 15 residue motif APC_basic (PF05956, IPR009234): APC basic domain APC_r (PF05923): APC repeat Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) EB1_binding (PF05937, IPR009232): EB-1 Binding Domain FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) SAMP (PF05924, IPR009224): SAMP Motif Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4 Arm_APC_u3 (PF16629): Armadillo-associated region on APC APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6 APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
10	ARHGEF2	oncoprotein	10	0.289	59.908	IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
11	BARD1	suppressor	12	0.145	93.758	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
12	BRCA1	suppressor	21	0.195	407.596	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
13	CAND1	interactor	14	0.333	76.510	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
14	CAND2	interactor	2	1.000	0	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
15	CAPNS1	interactor	4	0.833	0.376	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
16	CCDC8	interactor	15	0.198	156.774	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
17	CDC5L	interactor	16	0.381	110.934	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
18	CEP128	interactor	16	0.392	66.280	DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
19	CEP162	interactor	8	0.714	7.066	DivIC (PF04977, IPR007060): Septum formation initiator HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Methyltransf_14 (PF08484, IPR013691): C-methyltransferase C-terminal domain OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20 Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2553 (PF10830, IPR020140): Protein of unknown function (DUF2553) DUF3073 (PF11273, IPR021426): Protein of unknown function (DUF3073) PIP49_N (PF14875, IPR029244): N-term cysteine-rich ER, FAM69 WRNPLPNID (PF15017): Putative WW-binding domain and destruction box PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain FAM76 (PF16046, IPR032017): FAM76 protein HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
20	CEP19	interactor	5	0.400	20.660	CEP19 (PF14933, IPR029412): CEP19-like protein
21	CEP192	interactor	8	0.464	14.300	Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain TMEM131_like (PF12371, IPR022113): Transmembrane protein 131-like MYCBPAP (PF14646, IPR032707): MYCBP-associated protein family ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
22	CEP44	interactor	10	0.378	44.090	DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Utp12 (PF04003, IPR007148): Dip2/Utp12 Family CEP44 (PF15007, IPR029157): Centrosomal spindle body, CEP44
23	CLDN1	suppressor	1	0	0	PMP22_Claudin (PF00822, IPR004031): PMP-22/EMP/MP20/Claudin family DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
24	CNTRL	oncoprotein	12	0.409	70.402	APG6 (PF04111, IPR007243): Autophagy protein Apg6 BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fez1 (PF06818): Fez1 Laminin_II (PF06009, IPR010307): Laminin Domain II Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMPIT (PF07851, IPR012926): TMPIT-like protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) LRR_9 (PF14580): Leucine-rich repeat
25	COIL	interactor	7	0.333	39.182	CDC45 (PF02724, IPR003874): CDC45-like protein Macoilin (PF09726, IPR019130): Transmembrane protein Coilin_N (PF15862, IPR031722): Coilin N-terminus
26	CSNK2B	interactor	19	0.170	330.088	CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
27	CTTNBP2NL	interactor	3	0.667	2.587	CortBP2 (PF09727, IPR019131): Cortactin-binding protein-2 RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
28	CUL7	protein found in more fusions	12	0.436	26.230	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
29	DCLRE1C	interactor	4	0.833	0.357	DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase DUF3290 (PF11694, IPR021707): Protein of unknown function (DUF3290) Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
30	DNAJB1	suppressor	4	0.333	7.683	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
31	EPS8	oncoprotein	5	0.333	7.617	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
32	FAM175B	interactor	3	0	8.759	Cluap1 (PF10234, IPR019366): Clusterin-associated protein-1 JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
33	FAM193A	interactor	1	0	0	CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 DUF1287 (PF06940, IPR009706): Domain of unknown function (DUF1287) UPF0239 (PF06783, IPR009621): Uncharacterised protein family (UPF0239) V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family DDRGK (PF09756, IPR019153, SM01128): DDRGK domain MRI (PF15325, IPR028278): Modulator of retrovirus infection FAM193_C (PF15914, IPR031802): FAM193 family C-terminal
34	FBF1	interactor	8	0.321	47.518	DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family YlqD (PF11068, IPR021297): YlqD protein KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
35	FBXO6	interactor	7	0.476	10.839	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
36	FEN1	oncoprotein	7	0.524	8.963	5_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
37	FLNC	interactor	5	0.300	23.966	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain
38	FN1	oncoprotein	17	0.213	243.254	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
39	FOXD4L6	interactor	1	0	0	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
40	FOXK1	interactor	6	0.467	77.809	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FHA (PF00498, IPR000253, SM00240): FHA domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
41	FOXK2	interactor	6	0.200	47.453	FHA (PF00498, IPR000253, SM00240): FHA domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
42	GRB2	oncoprotein	14	0.167	142.746	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
43	HAO1	interactor	1	0	0	FMN_dh (PF01070, IPR000262): FMN-dependent dehydrogenase
44	HDGF	interactor	7	0.571	8.207	PWWP (PF00855, IPR000313, SM00293): PWWP domain
45	HECTD1	interactor	5	0.667	1.896	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein MIB_HERC2 (PF06701, IPR010606): Mib_herc2 NOA36 (PF06524, IPR010531): NOA36 protein Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
46	HECW2	interactor	9	0.107	82.118	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57 RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
47	HOXC4	interactor	2	1.000	0	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
48	IFRD2	oncoprotein	1	0	0	IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) IFRD_C (PF04836, IPR006921): Interferon-related protein conserved region
49	ITGA4	interactor	13	0.439	61.069	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
50	KIF23	interactor	5	0.200	27.853	DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730) Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
51	KRI1	interactor	4	0.167	17.015	Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain Vpu (PF00558, IPR008187): Vpu protein Kri1 (PF05178, IPR018034): KRI1-like family Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa) SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Kri1_C (PF12936, IPR024626): KRI1-like family C-terminal
52	LCA5	interactor	8	0.393	31.714	IncA (PF04156, IPR007285): IncA protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Tantalus (PF15386, IPR028149): Drosophila Tantalus-like Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
53	LEO1	interactor	3	0.667	1.642	Leo1 (PF04004, IPR007149): Leo1-like protein PPP4R2 (PF09184, IPR015267): PPP4R2 EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
54	LRRC41	interactor	3	0.667	0.830	LRR_6 (PF13516, IPR001611): Leucine Rich repeat
55	MAGED1	protein found in more fusions	10	0.389	34.673	MAGE (PF01454, IPR002190): MAGE family
56	MAST3	interactor	4	0	10.321	DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain ACTL7A_N (PF16840, IPR031769): Actin-like protein 7A N-terminus
57	MOB1A	suppressor	8	0.714	26.790	Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
58	MOB1B	suppressor	6	1.000	0	Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
59	MTMR3	oncoprotein	1	0	0	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
60	NAA15	interactor	10	0.333	102.942	NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1 ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
61	NECAP2	interactor	4	0.500	11.741	DUF1681 (PF07933, IPR012466): Protein of unknown function (DUF1681)
62	NEK4	interactor	3	0.333	3.397	Pkinase (PF00069, IPR000719): Protein kinase domain Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
63	NFATC4	interactor	1	0	0	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
64	NOTCH2	suppressor	2	1.000	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
65	NTMT1	interactor	1	0	0	Methyltransf_PK (PF05891, IPR008576): AdoMet dependent proline di-methyltransferase
66	NTRK1	oncoprotein	39	0.171	1192.710	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
67	ODF2	interactor	11	0.491	23.472	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) NAT (PF04768, IPR006855): NAT, N-acetyltransferase, of N-acetylglutamate synthase Invasin_D3 (PF09134, IPR015217): Invasin, domain 3 Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H) CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
68	PAXIP1	interactor	10	0.289	51.320	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
69	PHC2	interactor	9	0.107	58.500	SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit zf-CGNR (PF11706, IPR021005): CGNR zinc finger DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692) PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
70	PHKG2	interactor	3	0.333	6.895	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain
71	PLEKHG1	interactor	6	0.800	4.101	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
72	PLK1	suppressor	18	0.275	181.533	Pkinase (PF00069, IPR000719): Protein kinase domain POLO_box (PF00659, IPR000959): POLO box duplicated region
73	PLK2	suppressor	3	0.333	2.863	Pkinase (PF00069, IPR000719): Protein kinase domain POLO_box (PF00659, IPR000959): POLO box duplicated region G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
74	PPP1R9A	interactor	2	0	4.011	DIRP (PF06584, IPR010561, SM01135): DIRP FliJ (PF02050, IPR012823): Flagellar FliJ protein PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) PKI (PF02827, IPR004171): cAMP-dependent protein kinase inhibitor SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 DUF2407_C (PF13373, IPR025390): DUF2407 C-terminal domain Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
75	PPP1R9B	interactor	2	1.000	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Stm1_N (PF09598, IPR019084): Stm1 TSC22 (PF01166, IPR000580): TSC-22/dip/bun family DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) PRIMA1 (PF16101): Proline-rich membrane anchor 1 NuDC (PF16273, IPR032572): Nuclear distribution C domain
76	PPP6C	interactor	16	0.408	123.667	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
77	PPP6R1	interactor	17	0.419	91.955	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
78	PPP6R2	interactor	15	0.429	82.368	SAMP (PF05924, IPR009224): SAMP Motif SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
79	PPP6R3	interactor	16	0.400	94.691	SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
80	RAD21	oncoprotein	11	0.382	85.758	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
81	RASSF8	suppressor	1	0	0	ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region FliD_C (PF07195, IPR010809): Flagellar hook-associated protein 2 C-terminus PEARLI-4 (PF05278, IPR007942): Arabidopsis phospholipase-like protein (PEARLI 4) RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
82	RCN2	interactor	2	0	1.642	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
83	RPGRIP1L	interactor	15	0.314	112.995	bZIP_1 (PF00170, IPR004827): bZIP transcription factor C2 (PF00168, IPR000008, SM00239): C2 domain DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FtsL (PF04999, IPR011922): Cell division protein FtsL T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1 BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4497 (PF14924): Protein of unknown function (DUF4497)
84	RPL10	suppressor	13	0.321	56.543	Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
85	RWDD1	interactor	2	1.000	0	RWD (PF05773, IPR006575, SM00591): RWD domain Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46
86	SDCBP	interactor	6	0.200	45.072	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
87	SDCCAG3	interactor	10	0.467	32.322	GA (PF01468, IPR002988, SM00844): GA module TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
88	SEC16A	interactor	7	0.524	18.014	APC_r (PF05923): APC repeat Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16 Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
89	SFN	suppressor	7	0.400	21.205	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
90	SHKBP1	interactor	4	0.167	13.213	BTB_2 (PF02214, IPR003131): BTB/POZ domain
91	SIRT7	interactor	19	0.193	291.459	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
92	SKIL	suppressor	6	0.400	11.227	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
93	SMC1A	oncoprotein	15	0.407	96.110	SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
94	SMC3	oncoprotein	16	0.325	148.871	SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
95	SNW1	protein found in more fusions	17	0.325	124.872	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
96	SNX18	interactor	3	0	8.759	PX (PF00787, IPR001683, SM00312): PX domain BAR_3_WASP_bdg (PF10456, IPR019497): WASP-binding domain of Sorting nexin protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
97	SRPK2	oncoprotein	9	0.250	62.968	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
98	SSX2IP	interactor	15	0.319	218.369	ZapB (PF06005, IPR009252): Cell division protein ZapB ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding YqzH (PF14164, IPR025546): YqzH-like protein
99	STAU1	protein found in more fusions	16	0.400	66.648	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
100	STK16	interactor	4	0.333	2.482	Pkinase (PF00069, IPR000719): Protein kinase domain
101	TAL1	oncoprotein	3	0	1.245	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
102	TBK1	interactor	13	0.409	79.058	DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain
103	TBKBP1	interactor	3	1.000	0	Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper Synthase_beta (PF11421, IPR020971): ATP synthase F1 beta subunit TBD (PF12845, IPR024581): TBD domain
104	TGM2	protein found in more fusions	5	0.333	14.367	Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
105	TRIM41	interactor	8	0.238	61.473	BUD22 (PF09073, IPR015158): BUD22 Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family RecR (PF02132, IPR023628): RecR protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain DUF3631 (PF12307, IPR022081): Protein of unknown function (DUF3631) zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
106	UBE2I	interactor	7	0.333	34.913	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
107	UBR5	protein found in more fusions	9	0.286	46.340	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SDA1 (PF05285, IPR007949): SDA1 HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
108	USP10	protein found in more fusions	8	0.381	45.794	PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase YukD (PF08817, IPR024962): WXG100 protein secretion system (Wss), protein YukD
109	USP21	interactor	6	0.300	21.195	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
110	USP49	interactor	5	0.700	1.905	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
111	VCAM1	interactor	12	0.303	84.196	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
112	WWOX	suppressor	3	0.667	1.473	adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain
113	XPO1	interactor	37	0.107	1175.522	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
114	XRCC6	oncoprotein	25	0.112	606.054	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain
115	ZC3H15	interactor	7	0.333	87.326	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus (PF16131, IPR032297): Torus domain DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46
116	ZNF512B	interactor	4	0.500	9.858	YTV (PF07639, IPR011521): YTV zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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