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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAP3K12, PACS2 (from a repository: Sat Mar 25 23:43:01 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins11 (47.83 %)
The number (and %) of the tumor suppressors1 (4.35 %)
Total number of binary PPIs (saturation %)53 (20.95 %)
The number (and %) of affected PPIs21 (39.62 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.478
Assortativity coefficient-0.3425
The network average Clustering coefficient0.505
The number (and %) of a zero Clustering coefficients6 (26.09 %)
The number (and %) of a zero Betweenness Centrality11 (47.83 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAP3K12,PACS2 All fusions
Proteins found in more fusions EGFR (see 2 fusions); FTL (see 3 fusions); HSP90AA1 (see 2 fusions); TSC22D1 (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAP3K12parental protein120.167199.167APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
2 PACS2parental protein90.111220.000Pacs-1 (PF10254, IPR019381): PACS-1 cytosolic sorting protein
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
3 ANAPC15interactor100Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
4 ASPMoncoprotein100CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RST (PF12174, IPR022003): RCD1-SRO-TAF4 (RST) plant domain
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
5 BIRC2oncoprotein50.83338.967BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
6 BIRC3oncoprotein50.83338.967BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
7 EGFRoncoprotein80.333157.100Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
8 ELAVL1oncoprotein50.33365.233RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9 FRA10AC1interactor100SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
Fra10Ac1 (PF09725, IPR019129): Folate-sensitive fragile site protein Fra10Ac1
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
10 FTLprotein found in more fusions200Ferritin (PF00210, IPR008331): Ferritin-like domain
11 HSP90AA1oncoprotein40.6671.300HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
12 LRRC46interactor21.0000LRR_9 (PF14580): Leucine-rich repeat
13 MAP2K7interactor50.5004.333Pkinase (PF00069, IPR000719): Protein kinase domain
14 MAPK6oncoprotein40.6674.467Pkinase (PF00069, IPR000719): Protein kinase domain
15 MAPK8IP1oncoprotein50.8331.300PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
16 MAPK8IP2interactor50.8331.300BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
17 MBIPinteractor31.0000DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
18 RGS1oncoprotein21.0000RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
19 RSRP1oncoprotein100RSRP (PF17069): Arginine/Serine-Rich protein 1
20 TINF2interactor200TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
21 TRAF2interactor60.500111.867MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
22 TSC22D1suppressor31.0000SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
23 WDR37interactor21.0000DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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