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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MSRB3, DNAJC9 (from a repository: Sun Jul 21 03:32:57 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins11 (26.83 %)
The number (and %) of the tumor suppressors8 (19.51 %)
Total number of binary PPIs (saturation %)186 (22.68 %)
The number (and %) of affected PPIs40 (21.51 %)
The number of possible different fusions10
PPI diameter4
PPI radius2
The average degree of PPI8.195
Assortativity coefficient-0.1759
The network average Clustering coefficient0.513
The number (and %) of a zero Clustering coefficients10 (24.39 %)
The number (and %) of a zero Betweenness Centrality13 (31.71 %)


List of the fusions

PPI for parental proteins: MSRB3,DNAJC9 All fusions
Proteins found in more fusions COPS5 (see 1 fusions); SART3 (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); MSH2 (see 1 fusions); RPA1 (see 1 fusions); FOXO1 (see 3 fusions); GAPDH (see 5 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 MSRB3parental protein100.044266.668SelR (PF01641, IPR002579): SelR domain
2 DNAJC9parental protein300.237572.143DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
3 AZIN1interactor100Orn_Arg_deC_N (PF02784, IPR022644): Pyridoxal-dependent decarboxylase, pyridoxal binding domain
Orn_DAP_Arg_deC (PF00278, IPR022643): Pyridoxal-dependent decarboxylase, C-terminal sheet domain
4 BAG4interactor90.8065.241BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
5 CAND1interactor170.61728.440Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
6 CLIC4oncoprotein21.0000GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
7 COPS5protein found in more fusions190.51073.614JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
8 CUL1suppressor180.61029.769Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
9 CUL3protein found in more fusions200.53850.440Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10 DCUN1D1interactor90.9170.626Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
11 DHX15interactor120.66717.173DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
AAA_29 (PF13555): P-loop containing region of AAA domain
12 FOXL2suppressor21.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
13 FOXM1oncoprotein100EspF (PF04806, IPR006891): EspF protein repeat
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
14 FOXO1suppressor200K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
15 FOXS1interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
16 GAPDHoncoprotein120.60057.100Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
17 GOLGA2interactor206.396ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
18 HIST1H3Ainteractor31.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
19 HIST1H3Einteractor30.6670.333Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
20 HIST1H4Ainteractor70.57110.757CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
21 HSPA4Linteractor50.9000.182HSP70 (PF00012, IPR013126): Hsp70 protein
22 HSPA5oncoprotein170.52550.287HSP70 (PF00012, IPR013126): Hsp70 protein
23 HSPA8oncoprotein160.59223.773HSP70 (PF00012, IPR013126): Hsp70 protein
24 HSPA9oncoprotein120.68217.459HSP70 (PF00012, IPR013126): Hsp70 protein
25 HYOU1interactor60.6674.070HSP70 (PF00012, IPR013126): Hsp70 protein
AbiEi_3_N (PF17194): Transcriptional regulator, AbiEi antitoxin N-terminal domain
26 LNX2interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
27 MAPK8IP2interactor200BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
28 MOV10interactor160.417181.848AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
29 MSH2suppressor70.8671.067MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
30 NTRK1oncoprotein210.374188.119I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
31 NXF1interactor130.364121.637NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
32 PFKPinteractor41.0000PFK (PF00365, IPR000023): Phosphofructokinase
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
33 PRDM4suppressor200zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Ecl1 (PF12855, IPR024368): Life-span regulatory factor
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
34 RPA1suppressor120.7277.570Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
35 RPA2oncoprotein110.7277.104RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
36 RPA3interactor120.7277.104Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
37 SART3protein found in more fusions61.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993)
Lsm_interact (PF05391, IPR008669): Lsm interaction motif
Phage_GPD (PF05954): Phage late control gene D protein (GPD)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_14 (PF13428): Tetratricopeptide repeat
MRI (PF15325, IPR028278): Modulator of retrovirus infection
LSM_int_assoc (PF16605): LSM-interacting associated unstructured
38 SUZ12suppressor302.489DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
39 TCF4suppressor206.396CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
40 TRIP6interactor30.6674.196DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
41 TSTA3interactor100Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
NICE-3 (PF07406, IPR010876): NICE-3 protein
Polysacc_synt_2 (PF02719, IPR003869): Polysaccharide biosynthesis protein

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