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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FAF2, KLK3 (from a repository: Thu Sep 19 08:27:21 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)244
The number (and %) of the onco-proteins56 (22.95 %)
The number (and %) of the tumor suppressors12 (4.92 %)
Total number of binary PPIs (saturation %)1328 (4.48 %)
The number (and %) of affected PPIs244 (18.37 %)
The number of possible different fusions37
PPI diameter4
PPI radius2
The average degree of PPI10.402
Assortativity coefficient-0.2795
The network average Clustering coefficient0.486
The number (and %) of a zero Clustering coefficients23 (9.43 %)
The number (and %) of a zero Betweenness Centrality54 (22.13 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KLK3,FAF2 All fusions
Proteins found in more fusions TUBG1 (see 1 fusions); HLA-B (see 4 fusions); FAF2/SARAF (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); S100A10 (see 1 fusions); LGALS3BP (see 2 fusions); MAP3K1 (see 1 fusions); UBE3A (see 1 fusions); OXA1L (see 1 fusions); PRKDC (see 2 fusions); UBE3C (see 1 fusions); ACTG1 (see 5 fusions); A2M/DNAJB1 (see 1 fusions); PJA2 (see 1 fusions); OS9 (see 2 fusions); UBC (see 7 fusions); MSH2 (see 1 fusions); MAGED1 (see 1 fusions); SYVN1 (see 1 fusions); VCP (see 4 fusions); PFKL (see 2 fusions); ACTN1 (see 3 fusions); HUWE1 (see 4 fusions); HLA-B/HLA-C (see 4 fusions); STOM (see 1 fusions); INSIG1 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); UBR5 (see 4 fusions); UBQLN2 (see 3 fusions); TUBA1B/TUBA1A (see 2 fusions); HLA-C (see 1 fusions); TUBA1B/TUBA1C (see 11 fusions); DDB1 (see 4 fusions); RPTOR (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KLK3parental protein90.139997.691Trypsin (PF00089, IPR001254, SM00020): Trypsin
2 FAF2parental protein2350.03543926.504DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
3 A2Mprotein found in more fusions100.19494.234A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
4 ABCB7interactor21.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
AAA_23 (PF13476): AAA domain
5 ABCD3interactor90.27817.423ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
6 ABCF2interactor50.6003.540ABC_tran (PF00005, IPR003439): ABC transporter
VIT1 (PF01988, IPR008217): VIT family
Rop (PF01815, IPR000769): Rop protein
ABC_tran_Xtn (PF12848, IPR032781): ABC transporter
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
7 ABHD17Binteractor100Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
Hydrolase_4 (PF12146, IPR022742): Serine aminopeptidase, S33
8 ACAD9interactor70.6196.333Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
9 ACADMoncoprotein90.44414.516Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
10 ACADSBinteractor30.6670.250Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
11 ACTG1protein found in more fusions90.39312.877Actin (PF00022, IPR004000, SM00268): Actin
12 ACTG2interactor40.6670.625Actin (PF00022, IPR004000, SM00268): Actin
13 ACTN1protein found in more fusions70.5336.008CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
14 ACTR5interactor40.5003.833Actin (PF00022, IPR004000, SM00268): Actin
DUF1542 (PF07564, IPR011439): Domain of Unknown Function (DUF1542)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
15 AHCTF1interactor21.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
ELYS (PF13934, IPR025151): Nuclear pore complex assembly
ELYS-bb (PF16687, IPR032040): beta-propeller of ELYS nucleoporin
16 ALBinteractor50.20031.208Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
17 ALDH1B1interactor80.39314.309Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
18 ALDH3A2interactor90.38913.052Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
19 ALPPinteractor50.5001.920Alk_phosphatase (PF00245, IPR001952, SM00098): Alkaline phosphatase
20 AMFRoncoprotein320.331163.939CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
21 APOBinteractor100.6674.400DUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081)
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
Phage_holin_6_1 (PF09682, IPR010026): Bacteriophage holin of superfamily 6 (Holin_LLH)
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
22 ARoncoprotein90.21492.943Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
23 ARAFoncoprotein100.40013.131Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
24 ARF3interactor21.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
25 ARF5interactor60.5335.289Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
26 ARL14EPinteractor100ARF7EP_C (PF14949, IPR029264): ARF7 effector protein C-terminus
27 ARL6IP1interactor40.6671.000Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
28 ATAD1interactor40.5001.117AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
PhoH (PF02562, IPR003714): PhoH-like protein
DUF3240 (PF11582, IPR021634): Protein of unknown function (DUF3240)
AAA_18 (PF13238): AAA domain
29 ATG9Ainteractor21.0000APG9 (PF04109, IPR007241): Autophagy protein Apg9
PRRSV_2b (PF07069, IPR009775): Porcine reproductive and respiratory syndrome virus 2b
30 ATP2B3interactor21.0000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
ATP_Ca_trans_C (PF12424, IPR022141): Plasma membrane calcium transporter ATPase C terminal
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
31 ATP2C1interactor40.6671.333Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
YoqO (PF14037, IPR025621): YoqO-like protein
32 ATP4Ainteractor50.6672.000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
H-K_ATPase_N (PF09040, IPR015127): Gastric H+/K+-ATPase, N terminal domain
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
33 ATP5Binteractor190.28793.595AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
34 ATP6V1Hinteractor40.6670.643V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
35 AUP1interactor170.37546.925CUE (PF02845, IPR003892, SM00546): CUE domain
36 BAG6interactor260.223214.382DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
37 BCKDHBinteractor21.0000Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
38 C19orf52interactor21.0000DUF2366 (PF10171, IPR019322): Uncharacterised conserved protein (DUF2366)
39 CALUinteractor120.42430.388EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
40 CAND1interactor260.297145.458Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
41 CAV1suppressor160.283108.390Caveolin (PF01146, IPR001612): Caveolin
42 CBR1interactor40.8330.286adh_short (PF00106, IPR002198): short chain dehydrogenase
43 CDKAL1interactor31.0000Radical_SAM (PF04055, IPR007197): Radical SAM superfamily
TRAM (PF01938, IPR002792): TRAM domain
UPF0004 (PF00919, IPR013848): Uncharacterized protein family UPF0004
44 CDKN2AIPinteractor41.0000XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
45 CLEC11Ainteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HBS1_N (PF08938, IPR015033): HBS1 N-terminus
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
46 COX4I1interactor70.6194.650COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
47 CSE1Loncoprotein150.37145.757CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
48 CUL1suppressor200.41550.141Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
49 CUL2suppressor250.283176.739Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
50 CUL3protein found in more fusions520.140858.506Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
51 DAGLBinteractor100Lipase_3 (PF01764, IPR002921): Lipase (class 3)
52 DCAF7interactor50.5003.248WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
53 DDB1protein found in more fusions150.363151.426CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
54 DERL1interactor260.247314.016DER1 (PF04511, IPR007599): Der1-like family
55 DERL2interactor160.40885.251DER1 (PF04511, IPR007599): Der1-like family
56 DMXL2interactor100eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Rav1p_C (PF12234, IPR022033): RAVE protein 1 C terminal
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
57 DNAJB1suppressor120.34871.042DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
58 ECE1interactor21.0000Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
59 ECSITinteractor150.253110.205ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
60 EGFRoncoprotein520.1061052.992Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
61 ELAVL1oncoprotein510.0831080.342RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
62 EMC1interactor100.33315.623DUF1620 (PF07774, IPR011678): Protein of unknown function (DUF1620)
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
PQQ_2 (PF13360, IPR002372): PQQ-like domain
63 EMDinteractor170.34245.064LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
64 ENO1oncoprotein130.34629.106Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
65 EPB41L3suppressor60.4675.0224_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
66 ERGIC1interactor21.0000COPIIcoated_ERV (PF07970, IPR012936): Endoplasmic reticulum vesicle transporter
ERGIC_N (PF13850): Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
67 ERLIN1interactor90.6114.477Ribosomal_L33 (PF00471, IPR001705): Ribosomal protein L33
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
68 ERLIN2interactor200.37959.090Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
69 ESYT1interactor60.4677.212C2 (PF00168, IPR000008, SM00239): C2 domain
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
70 ESYT2interactor50.5005.164C2 (PF00168, IPR000008, SM00239): C2 domain
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
71 EVI5Linteractor30.33325.676DivIC (PF04977, IPR007060): Septum formation initiator
Nnf1 (PF03980, IPR007128): Nnf1
PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
72 FAM46Ainteractor30.6670.250NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
73 FASsuppressor100.33324.076Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
74 FBXO6interactor580.1091333.435FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
75 FN1oncoprotein370.110862.982fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
76 FUNDC2interactor31.0000FUN14 (PF04930, IPR007014): FUN14 family
77 GCATinteractor40.5001.203Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
78 GCDHinteractor60.53330.540Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
79 GCN1interactor130.256144.218Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
80 GDAP1interactor100SyrA (PF11089, IPR024239): Exopolysaccharide production repressor
GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
DUF4296 (PF14129, IPR025381): Domain of unknown function (DUF4296)
81 GET4interactor110.7453.971DUF410 (PF04190, IPR007317): Protein of unknown function (DUF410)
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
82 GPD2interactor30.6670.500DAO (PF01266, IPR006076): FAD dependent oxidoreductase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DAO_C (PF16901, IPR031656): C-terminal domain of alpha-glycerophosphate oxidase
83 HACD3interactor60.4003.849PTPLA (PF04387, IPR007482): Protein tyrosine phosphatase-like protein, PTPLA
84 HAUS2interactor80.42912.096DpnII (PF04556, IPR007637): DpnII restriction endonuclease
HAUS2 (PF15003, IPR028346): HAUS augmin-like complex subunit 2
85 HIF1Asuppressor120.34836.467Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
86 HLA-Boncoprotein70.53310.792MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
87 HLA-Cprotein found in more fusions90.50016.171Marek_A (PF02124, IPR001038): Marek's disease glycoprotein A
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
88 HLA-Ginteractor31.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
SNO (PF01174, IPR002161): SNO glutamine amidotransferase family
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
89 HMGCRoncoprotein90.7223.327HMG-CoA_red (PF00368, IPR002202): Hydroxymethylglutaryl-coenzyme A reductase
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
90 HSP90B1suppressor260.311133.430CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
91 HSPA5oncoprotein430.2291301.559HSP70 (PF00012, IPR013126): Hsp70 protein
92 HUWE1oncoprotein300.291173.763BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
93 ILVBLinteractor70.3815.509TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
94 INSIG1protein found in more fusions100.6116.078INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
95 INSIG2interactor90.52811.022INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
96 INTS3interactor50.4005.511SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
Fn_bind (PF02986, IPR004237): Fibronectin binding repeat
Ints3 (PF10189, IPR019333): Integrator complex subunit 3
97 INTS4interactor30.6671.000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
98 INTS7interactor30.6671.000DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
SPG48 (PF14764, IPR028222): AP-5 complex subunit, vesicle trafficking
99 IPO9interactor60.5334.679IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_EZ (PF13513): HEAT-like repeat
100 KIDINS220interactor40.8332.998KAP_NTPase (PF07693, IPR011646): KAP family P-loop domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
101 KRT18interactor50.6673.652Filament (PF00038, IPR001664): Intermediate filament protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
102 KRT8interactor50.5005.584Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
103 LARSinteractor50.3009.066Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
104 LGALS3BPoncoprotein140.48724.136BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
105 LPCAT1interactor40.5001.952JmjN (PF02375, IPR003349, SM00545): jmjN domain
Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
106 MAGED1protein found in more fusions100.44414.106MAGE (PF01454, IPR002190): MAGE family
107 MAP3K1oncoprotein100.47210.273zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
108 MCM2oncoprotein410.168521.013AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
109 MCM9suppressor21.0000MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_OB (PF17207): MCM OB domain
110 MCUBinteractor21.0000MCU (PF04678, IPR006769): Mitochondrial calcium uniporter
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
111 MCUR1interactor100DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640)
DUF3708 (PF12501, IPR022182): Phosphate ATP-binding cassette transporter
112 MFN1interactor100Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
Tup_N (PF08581, IPR013890): Tup N-terminal
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
113 MIF4GDinteractor100MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
114 MRPL21interactor21.0000Ribosomal_L21p (PF00829, IPR028909): Ribosomal prokaryotic L21 protein
115 MRPL37interactor50.6001.236PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
116 MSH2suppressor50.6671.067MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
117 MSH6oncoprotein50.6002.540MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
PWWP (PF00855, IPR000313, SM00293): PWWP domain
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
UPF0524 (PF15823, IPR029670): UPF0524 of C3orf70
118 MT-CO2interactor100.40036.369COX2 (PF00116, IPR002429): Cytochrome C oxidase subunit II, periplasmic domain
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
119 MTHFD1interactor100.46711.292FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
120 NDUFAF1interactor50.9000.500CIA30 (PF08547, IPR013857): Complex I intermediate-associated protein 30 (CIA30)
121 NDUFS2interactor60.5335.108Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
122 NF1suppressor31.0000MIF4G_like_2 (PF09090, IPR015174): MIF4G like
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
MOR2-PAG1_C (PF14225, IPR025481): Cell morphogenesis C-terminal
123 NNTinteractor50.5003.458AlaDh_PNT_C (PF01262, IPR007698, SM01002): Alanine dehydrogenase/PNT, C-terminal domain
AlaDh_PNT_N (PF05222, IPR007886, SM01003): Alanine dehydrogenase/PNT, N-terminal domain
PNTB (PF02233, IPR012136): NAD(P) transhydrogenase beta subunit
PNTB_4TM (PF12769, IPR024605): 4TM region of pyridine nucleotide transhydrogenase, mitoch
124 NOCTinteractor100Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
125 NPEPPSinteractor40.6670.522Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
126 NPLOC4interactor230.340101.808NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
127 NUP85interactor50.7002.143Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
128 OATinteractor50.8000.750Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
129 ORAI1interactor100Orai-1 (PF07856, IPR012446): Mediator of CRAC channel activity
130 OS9protein found in more fusions170.48379.505DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
131 OXA1Lprotein found in more fusions40.6670.40060KD_IMP (PF02096, IPR001708): 60Kd inner membrane protein
132 PCK1interactor110.27331.665PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
133 PEX11Binteractor31.0000PEX11 (PF05648, IPR008733): Peroxisomal biogenesis factor 11 (PEX11)
134 PEX19interactor80.32113.200Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
135 PFKLprotein found in more fusions90.5369.651PFK (PF00365, IPR000023): Phosphofructokinase
136 PFKPinteractor90.5289.539PFK (PF00365, IPR000023): Phosphofructokinase
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
137 PJA1interactor50.6671.000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
138 PJA2protein found in more fusions90.5715.971zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
139 PNPLA2interactor100Patatin (PF01734, IPR002641): Patatin-like phospholipase
140 PNPLA6interactor21.0000Patatin (PF01734, IPR002641): Patatin-like phospholipase
PT (PF04886, IPR006970): PT repeat
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
141 POLD3interactor100CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
142 PRKDCprotein found in more fusions170.292101.602FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
143 PSEN2oncoprotein80.3819.974Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
Presenilin (PF01080, IPR001108): Presenilin
144 PSMD2oncoprotein140.26438.213PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
145 PTGS2oncoprotein80.7142.856An_peroxidase (PF03098, IPR002007): Animal haem peroxidase
EGF (PF00008, IPR000742, SM00181): EGF-like domain
146 RAB5Concoprotein110.36439.125Ras (PF00071, IPR001806, SM00173): Ras family
147 RAB7Asuppressor200.268121.262Ras (PF00071, IPR001806, SM00173): Ras family
148 RAB9Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
149 RBM14-RBM4interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
CompInhib_SCIN (PF11546, IPR021612): Staphylococcal complement inhibitor SCIN
ACC_epsilon (PF13822, IPR032716): Acyl-CoA carboxylase epsilon subunit
150 RGS20interactor100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
151 RNF126interactor170.30863.585Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zinc_ribbon_9 (PF14369): zinc-ribbon
152 RNF2interactor260.153240.322zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
153 RPTORprotein found in more fusions50.5001.833HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
154 RRM2interactor31.0000Ribonuc_red_sm (PF00268, IPR000358): Ribonucleotide reductase, small chain
155 S100A10oncoprotein40.6671.000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
156 SAE1interactor30.6670.400ThiF (PF00899, IPR000594): ThiF family
157 SARAFprotein found in more fusions61.0000SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
158 SEL1Loncoprotein130.57714.226fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
159 SELENOSinteractor110.6189.651Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
DUF3326 (PF11805, IPR021763): Protein of unknown function (DUF3326)
160 SERPINA1oncoprotein70.52438.909Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
161 SERPINA5interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
162 SERPINH1interactor110.36423.299Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
163 SETDB1interactor50.4006.168MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
164 SLC25A10interactor30.6670.143Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
165 SLC25A16interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
166 SLC25A22interactor50.6000.798Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
DUF4257 (PF14074, IPR025353): Protein of unknown function (DUF4257)
167 SLC25A24interactor30.6671.154Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
168 SLC25A4interactor40.5002.163Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
169 SLC26A6interactor100STAS (PF01740, IPR002645): STAS domain
Sulfate_transp (PF00916, IPR011547): Sulfate permease family
170 SORT1interactor40.5001.556Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3,
171 SPG7oncoprotein100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
AAA_22 (PF13401, IPR003593): AAA domain
172 SQLEinteractor100FAD_binding_3 (PF01494, IPR002938): FAD binding domain
SE (PF08491, IPR013698): Squalene epoxidase
CBP_BcsF (PF11120, IPR019995): Cellulose biosynthesis protein BcsF
173 STK17Binteractor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
174 STOMprotein found in more fusions80.5245.477Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
175 STT3Ainteractor60.4004.238STT3 (PF02516, IPR003674): Oligosaccharyl transferase STT3 subunit
176 SUCLA2interactor40.5002.792ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
nsp7 (PF08716, IPR014828): nsp7 replicase
177 SUCLG2interactor50.7002.167ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
178 SYVN1protein found in more fusions220.39070.821Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
179 TARBP1interactor21.0000SpoU_methylase (PF00588, IPR001537): SpoU rRNA Methylase family
180 TBCDinteractor21.0000HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
HEAT_EZ (PF13513): HEAT-like repeat
181 TCEB1oncoprotein60.6672.768Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
182 TCTN2interactor200.189135.076DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
183 TIMM17Binteractor30.6671.000Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
184 TIMM23interactor50.5004.336Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
185 TIMM23Binteractor21.0000Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
186 TIMMDC1interactor70.5718.705Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
187 TM9SF3interactor30.6670.200EMP70 (PF02990, IPR004240): Endomembrane protein 70
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
DUF4231 (PF14015, IPR025325): Protein of unknown function (DUF4231)
188 TMED2interactor50.5004.381EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
189 TMED9interactor50.6002.481EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
190 TMEM159interactor21.0000IncA (PF04156, IPR007285): IncA protein
Promethin (PF16015): Promethin
191 TMEM43interactor40.8330.400TMEM43 (PF07787, IPR012430): Transmembrane protein 43
UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
192 TMEM55Binteractor100Tmemb_55A (PF09788, IPR019178): Transmembrane protein 55A
193 TOMM20interactor70.38111.524RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
194 TOMM22interactor90.41712.415Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
195 TOMM40interactor90.33318.615Porin_3 (PF01459, IPR027246): Eukaryotic porin
196 TRA2Binteractor70.5713.375RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
197 TRAM1interactor30.6670.222TRAM1 (PF08390, IPR013599): TRAM1-like protein
TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
DUF3671 (PF12420, IPR022139): Protein of unknown function
198 TROinteractor21.0000MAGE (PF01454, IPR002190): MAGE family
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
AP3D1 (PF06375): AP-3 complex subunit delta-1
199 TTC27interactor40.6670.667TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TraH (PF06122, IPR010927): Conjugative relaxosome accessory transposon protein
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
200 TUBA1Aoncoprotein160.40031.100Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
201 TUBA1Bprotein found in more fusions90.38943.313Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
202 TUBA1Cprotein found in more fusions250.293133.750Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
203 TUBA4Ainteractor140.49518.435Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
204 TUBB3interactor150.41930.781Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
205 TUBG1protein found in more fusions160.36241.941Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
206 UBA52interactor60.20067.506Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
207 UBAC2interactor200.221107.319Rhomboid (PF01694, IPR022764): Rhomboid family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
208 UBBinteractor110.38221.744ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
209 UBCprotein found in more fusions550.173886.200ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
210 UBE2D1interactor190.34046.350UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
211 UBE2J1interactor130.50021.579UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
ATPase-cat_bd (PF12156, IPR021993): Putative metal-binding domain of cation transport ATPase
212 UBE3Aoncoprotein150.34175.031HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
213 UBE3Cprotein found in more fusions70.4672.893IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
214 UBL4Ainteractor290.241295.777ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
215 UBQLN2protein found in more fusions90.4297.815Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
216 UBR1interactor70.7621.654ATPase_2 (PF01637, IPR011579): ATPase domain predominantly from Archaea
ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
217 UBR2interactor41.0000ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
218 UBR4interactor80.6075.399CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
RecR (PF02132, IPR023628): RecR protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
DZR (PF12773, IPR025874): Double zinc ribbon
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
FAM176 (PF14851): FAM176 family
219 UBR5protein found in more fusions130.48519.540CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
220 UBXN1interactor300.333158.816Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
221 UBXN6interactor130.34629.723PUB (PF09409, IPR018997): PUB domain
UBX (PF00789, IPR001012, SM00166): UBX domain
222 UBXN7interactor240.341103.302UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
223 UFD1Linteractor230.352152.770UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
224 UNC45Ainteractor80.5368.155Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
TPR_16 (PF13432): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
225 UQCRC2oncoprotein170.30160.398Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
226 UQCRQinteractor100.31123.920UcrQ (PF02939, IPR004205): UcrQ family
227 USP13interactor110.61816.515UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
228 USP19interactor130.24443.099CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
229 VAPBinteractor140.29749.685ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
230 VCPprotein found in more fusions580.1871070.585AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
231 VCPIP1interactor100.6895.524ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C3H1 (PF10650, IPR019607, SM00356): Putative zinc-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SDP_N (PF12278, IPR022063): Sex determination protein N terminal
232 VDAC2interactor190.269167.735Porin_3 (PF01459, IPR027246): Eukaryotic porin
233 VDAC3interactor150.30596.349Porin_3 (PF01459, IPR027246): Eukaryotic porin
234 VMP1interactor31.0000SNARE_assoc (PF09335, IPR015414): SNARE associated Golgi protein
235 VPS13Ainteractor30.6670.500ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
DUF1493 (PF07377, IPR010862): Protein of unknown function (DUF1493)
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
VPS13_mid_rpt (PF16910, IPR031642): Repeating coiled region of VPS13
236 VPS13Cinteractor100ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
WWE (PF02825, IPR004170, SM00678): WWE domain
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
VPS13_mid_rpt (PF16910, IPR031642): Repeating coiled region of VPS13
237 VPS52interactor200Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
238 VRK2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
VP_N-CPKC (PF11475, IPR021573): Virion protein N terminal domain
239 WDR26interactor50.6002.184eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
240 XPR1interactor40.8330.333EXS (PF03124, IPR004342): EXS family
SPX (PF03105, IPR004331): SPX domain
241 YES1oncoprotein40.6673.198Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
242 YIPF5interactor60.6004.067Yip1 (PF04893, IPR006977): Yip1 domain
243 YOD1interactor110.6367.998OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
244 ZFAND2Binteractor70.5712.895UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger

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