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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FAF2, ARPC1A (from a repository: Wed Jul 24 18:13:31 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)267
The number (and %) of the onco-proteins60 (22.47 %)
The number (and %) of the tumor suppressors15 (5.62 %)
Total number of binary PPIs (saturation %)1578 (4.44 %)
The number (and %) of affected PPIs268 (16.98 %)
The number of possible different fusions40
PPI diameter4
PPI radius2
The average degree of PPI11.333
Assortativity coefficient-0.2626
The network average Clustering coefficient0.473
The number (and %) of a zero Clustering coefficients21 (7.87 %)
The number (and %) of a zero Betweenness Centrality49 (18.35 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ARPC1A,FAF2 All fusions
Proteins found in more fusions TUBG1 (see 1 fusions); HLA-B (see 4 fusions); FAF2/SARAF (see 1 fusions); CUL7 (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); S100A10 (see 1 fusions); LGALS3BP (see 2 fusions); MAP3K1 (see 1 fusions); UBE3A (see 1 fusions); OXA1L (see 1 fusions); PRKDC (see 2 fusions); UBE3C (see 1 fusions); ACTG1 (see 5 fusions); PJA2 (see 1 fusions); OS9 (see 2 fusions); UBC (see 7 fusions); MSH2 (see 1 fusions); TPD52L2 (see 2 fusions); MAGED1 (see 1 fusions); SYVN1 (see 1 fusions); VCP (see 4 fusions); PFKL (see 2 fusions); ACTN1 (see 3 fusions); HUWE1 (see 4 fusions); CALR (see 8 fusions); HLA-B/HLA-C (see 4 fusions); STOM (see 1 fusions); BAG3 (see 4 fusions); INSIG1 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); UBR5 (see 4 fusions); UBQLN2 (see 3 fusions); TUBA1B/TUBA1A (see 2 fusions); HLA-C (see 1 fusions); TUBA1B/TUBA1C (see 11 fusions); DDB1 (see 4 fusions); RPTOR (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARPC1Aparental protein330.2781451.453WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
2 FAF2parental protein2350.03546812.923DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
3 AARSD1interactor140.48472.484tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
4 ABCB7interactor21.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
AAA_23 (PF13476): AAA domain
5 ABCD3interactor90.27823.055ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
6 ABCF2interactor50.6005.616ABC_tran (PF00005, IPR003439): ABC transporter
VIT1 (PF01988, IPR008217): VIT family
Rop (PF01815, IPR000769): Rop protein
ABC_tran_Xtn (PF12848, IPR032781): ABC transporter
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
7 ABHD17Binteractor100Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
Hydrolase_4 (PF12146, IPR022742): Serine aminopeptidase, S33
8 ACAD9interactor70.6196.333Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
9 ACADMoncoprotein100.35679.693Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
10 ACADSBinteractor30.6670.473Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
11 ACTG1protein found in more fusions90.35733.222Actin (PF00022, IPR004000, SM00268): Actin
12 ACTG2interactor40.6670.821Actin (PF00022, IPR004000, SM00268): Actin
13 ACTN1protein found in more fusions90.32148.109CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
14 ACTR2interactor220.459573.309Actin (PF00022, IPR004000, SM00268): Actin
15 ACTR3interactor180.529185.173Actin (PF00022, IPR004000, SM00268): Actin
16 ACTR3Binteractor90.80615.650Actin (PF00022, IPR004000, SM00268): Actin
17 ACTR5interactor40.5003.051Actin (PF00022, IPR004000, SM00268): Actin
DUF1542 (PF07564, IPR011439): Domain of Unknown Function (DUF1542)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
18 AGFG1interactor50.40027.349ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
19 AHCTF1interactor21.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
ELYS (PF13934, IPR025151): Nuclear pore complex assembly
ELYS-bb (PF16687, IPR032040): beta-propeller of ELYS nucleoporin
20 ALDH1B1interactor70.4768.045Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
21 ALDH3A2interactor90.38915.989Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
22 ALPPinteractor50.5001.850Alk_phosphatase (PF00245, IPR001952, SM00098): Alkaline phosphatase
23 AMFRoncoprotein320.331185.074CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
24 APOBinteractor110.60021.587DUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081)
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
Phage_holin_6_1 (PF09682, IPR010026): Bacteriophage holin of superfamily 6 (Holin_LLH)
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
25 ARAFoncoprotein110.36430.837Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
26 ARF3interactor21.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
27 ARF5interactor60.5336.795Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
28 ARL14EPinteractor204.712ARF7EP_C (PF14949, IPR029264): ARF7 effector protein C-terminus
29 ARL6IP1interactor40.6671.687Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
30 ARPC2interactor230.458275.463P34-Arc (PF04045, IPR007188): Arp2/3 complex, 34 kD subunit p34-Arc
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
31 ARPC3interactor170.559142.212P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
32 ARPC4interactor190.474205.991ARPC4 (PF05856, IPR008384): ARP2/3 complex 20 kDa subunit (ARPC4)
33 ARPC4-TTLL3interactor71.0000ARPC4 (PF05856, IPR008384): ARP2/3 complex 20 kDa subunit (ARPC4)
TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
34 ARPC5interactor170.529142.378P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
35 ARPC5Linteractor160.608102.696P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
36 ATAD1interactor40.5001.865AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
PhoH (PF02562, IPR003714): PhoH-like protein
DUF3240 (PF11582, IPR021634): Protein of unknown function (DUF3240)
AAA_18 (PF13238): AAA domain
37 ATG9Ainteractor21.0000APG9 (PF04109, IPR007241): Autophagy protein Apg9
PRRSV_2b (PF07069, IPR009775): Porcine reproductive and respiratory syndrome virus 2b
38 ATP2B3interactor21.0000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
ATP_Ca_trans_C (PF12424, IPR022141): Plasma membrane calcium transporter ATPase C terminal
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
39 ATP2C1interactor40.6672.118Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
YoqO (PF14037, IPR025621): YoqO-like protein
40 ATP4Ainteractor50.6671.800Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
H-K_ATPase_N (PF09040, IPR015127): Gastric H+/K+-ATPase, N terminal domain
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
41 ATP5Binteractor200.268137.919AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
42 ATP6V1Hinteractor40.6671.100V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
43 AUP1interactor170.37551.285CUE (PF02845, IPR003892, SM00546): CUE domain
44 BAG3oncoprotein130.121159.705BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
45 BAG6interactor270.215404.173DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
46 BCKDHBinteractor21.0000Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
47 C19orf52interactor21.0000DUF2366 (PF10171, IPR019322): Uncharacterised conserved protein (DUF2366)
48 CALRoncoprotein240.308396.838Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
49 CALUinteractor300.3131841.977EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
50 CAND1interactor250.301129.346Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
51 CAV1suppressor180.229277.992Caveolin (PF01146, IPR001612): Caveolin
52 CBR1interactor50.6004.049adh_short (PF00106, IPR002198): short chain dehydrogenase
53 CDKAL1interactor31.0000Radical_SAM (PF04055, IPR007197): Radical SAM superfamily
TRAM (PF01938, IPR002792): TRAM domain
UPF0004 (PF00919, IPR013848): Uncharacterized protein family UPF0004
54 CDKN2AIPinteractor60.46736.362XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
55 CLEC11Ainteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HBS1_N (PF08938, IPR015033): HBS1 N-terminus
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
56 CNDP2suppressor30.33310.387Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
57 COX4I1interactor70.6194.907COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
58 CSE1Loncoprotein160.342292.318CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
59 CUL1suppressor200.41548.040Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
60 CUL2suppressor250.280306.572Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
61 CUL3protein found in more fusions550.1261499.208Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
62 CUL7protein found in more fusions450.0681337.896ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
63 DAGLBinteractor100Lipase_3 (PF01764, IPR002921): Lipase (class 3)
64 DBN1oncoprotein190.240289.165Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
65 DCAF7interactor70.38133.066WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
66 DDB1protein found in more fusions150.37455.732CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
67 DERL1interactor240.285141.080DER1 (PF04511, IPR007599): Der1-like family
68 DERL2interactor150.43842.288DER1 (PF04511, IPR007599): Der1-like family
69 DMXL2interactor100eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Rav1p_C (PF12234, IPR022033): RAVE protein 1 C terminal
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
70 DNAJB1suppressor100.40026.480DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
71 ECE1interactor30.66717.157Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
72 ECSITinteractor140.26953.529ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
73 EGFRoncoprotein570.0952059.921Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
74 ELAVL1oncoprotein580.0782782.054RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
75 EMC1interactor110.29132.235DUF1620 (PF07774, IPR011678): Protein of unknown function (DUF1620)
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
PQQ_2 (PF13360, IPR002372): PQQ-like domain
76 EMDinteractor180.31676.446LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
77 ENO1oncoprotein150.28699.517Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
78 EPB41L3suppressor60.4675.2974_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
79 ERGIC1interactor21.0000COPIIcoated_ERV (PF07970, IPR012936): Endoplasmic reticulum vesicle transporter
ERGIC_N (PF13850): Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
80 ERLIN1interactor110.45547.149Ribosomal_L33 (PF00471, IPR001705): Ribosomal protein L33
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
81 ERLIN2interactor190.39250.312Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
82 ESYT1interactor50.6002.567C2 (PF00168, IPR000008, SM00239): C2 domain
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
83 ESYT2interactor40.6671.400C2 (PF00168, IPR000008, SM00239): C2 domain
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
84 EVI5Linteractor30.3337.355DivIC (PF04977, IPR007060): Septum formation initiator
Nnf1 (PF03980, IPR007128): Nnf1
PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
85 FAM46Ainteractor30.6670.250NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
86 FASsuppressor100.33328.478Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
87 FBXO6interactor570.1141337.428FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
88 FUNDC2interactor31.0000FUN14 (PF04930, IPR007014): FUN14 family
89 GCATinteractor40.5001.797Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
90 GCDHinteractor50.6003.167Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
91 GCN1interactor120.25838.154Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
92 GDAP1interactor100SyrA (PF11089, IPR024239): Exopolysaccharide production repressor
GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
DUF4296 (PF14129, IPR025381): Domain of unknown function (DUF4296)
93 GET4interactor110.7454.751DUF410 (PF04190, IPR007317): Protein of unknown function (DUF410)
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
94 GON7interactor21.0000DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
95 GPD2interactor40.5006.511DAO (PF01266, IPR006076): FAD dependent oxidoreductase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DAO_C (PF16901, IPR031656): C-terminal domain of alpha-glycerophosphate oxidase
96 HACD3interactor70.2869.424PTPLA (PF04387, IPR007482): Protein tyrosine phosphatase-like protein, PTPLA
97 HAUS2interactor90.41725.864DpnII (PF04556, IPR007637): DpnII restriction endonuclease
HAUS2 (PF15003, IPR028346): HAUS augmin-like complex subunit 2
98 HIF1Asuppressor110.38223.953Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
99 HLA-Boncoprotein70.5338.008MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
100 HLA-Cprotein found in more fusions100.44427.602Marek_A (PF02124, IPR001038): Marek's disease glycoprotein A
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
101 HLA-Ginteractor31.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
SNO (PF01174, IPR002161): SNO glutamine amidotransferase family
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
102 HMGCRoncoprotein90.7224.527HMG-CoA_red (PF00368, IPR002202): Hydroxymethylglutaryl-coenzyme A reductase
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
103 HSP90B1suppressor280.296222.459CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
104 HSPA5oncoprotein400.251404.689HSP70 (PF00012, IPR013126): Hsp70 protein
105 HUWE1oncoprotein330.256468.101BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
106 ILVBLinteractor70.3817.614TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
107 INSIG1protein found in more fusions100.6117.820INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
108 INSIG2interactor90.5289.920INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
109 INTS3interactor60.26766.839SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
Fn_bind (PF02986, IPR004237): Fibronectin binding repeat
Ints3 (PF10189, IPR019333): Integrator complex subunit 3
110 INTS4interactor30.6671.200Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
111 INTS7interactor30.6671.333DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
SPG48 (PF14764, IPR028222): AP-5 complex subunit, vesicle trafficking
112 IPO9interactor70.42915.409IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_EZ (PF13513): HEAT-like repeat
113 KIDINS220interactor31.0000KAP_NTPase (PF07693, IPR011646): KAP family P-loop domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
114 KRT18interactor50.3337.932Filament (PF00038, IPR001664): Intermediate filament protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
115 KRT8interactor40.5002.349Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
116 LARSinteractor40.5002.327Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
117 LGALS3BPoncoprotein150.42936.450BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
118 LPCAT1interactor40.5003.231JmjN (PF02375, IPR003349, SM00545): jmjN domain
Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
119 MAGED1protein found in more fusions110.35662.439MAGE (PF01454, IPR002190): MAGE family
120 MAP3K1oncoprotein110.42222.246zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
121 MCM2oncoprotein440.1521071.599AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
122 MCM9suppressor21.0000MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_OB (PF17207): MCM OB domain
123 MCUBinteractor21.0000MCU (PF04678, IPR006769): Mitochondrial calcium uniporter
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
124 MCUR1interactor100DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640)
DUF3708 (PF12501, IPR022182): Phosphate ATP-binding cassette transporter
125 MFN1interactor100Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
Tup_N (PF08581, IPR013890): Tup N-terminal
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
126 MRPL21interactor21.0000Ribosomal_L21p (PF00829, IPR028909): Ribosomal prokaryotic L21 protein
127 MRPL37interactor50.6001.661PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
128 MSH2suppressor50.6671.495MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
129 MSH6oncoprotein50.6003.621MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
PWWP (PF00855, IPR000313, SM00293): PWWP domain
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
UPF0524 (PF15823, IPR029670): UPF0524 of C3orf70
130 MT-CO2interactor100.40037.410COX2 (PF00116, IPR002429): Cytochrome C oxidase subunit II, periplasmic domain
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
131 MTHFD1interactor120.37955.594FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
132 MTRinteractor70.57129.832B12-binding (PF02310, IPR006158): B12 binding domain
B12-binding_2 (PF02607, IPR003759, SM01018): B12 binding domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
Met_synt_B12 (PF02965, IPR004223): Vitamin B12 dependent methionine synthase, activation domain
Pterin_bind (PF00809, IPR000489): Pterin binding enzyme
S-methyl_trans (PF02574, IPR003726): Homocysteine S-methyltransferase
DUF2760 (PF10816, IPR021212): Domain of unknown function (DUF2760)
133 NCAPD2oncoprotein31.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
HEAT (PF02985, IPR000357): HEAT repeat
LrgA (PF03788, IPR005538): LrgA family
Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
134 NCAPGinteractor60.400181.857P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
Terminase_2 (PF03592, IPR005335): Terminase small subunit
UVR (PF02151, IPR001943): UvrB/uvrC motif
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
HEAT_2 (PF13646): HEAT repeats
135 NCAPHinteractor60.333149.705Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
136 NDUFAF1interactor50.9000.500CIA30 (PF08547, IPR013857): Complex I intermediate-associated protein 30 (CIA30)
137 NDUFS2interactor60.5337.107Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
138 NF1suppressor31.0000MIF4G_like_2 (PF09090, IPR015174): MIF4G like
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
MOR2-PAG1_C (PF14225, IPR025481): Cell morphogenesis C-terminal
139 NNTinteractor60.40012.364AlaDh_PNT_C (PF01262, IPR007698, SM01002): Alanine dehydrogenase/PNT, C-terminal domain
AlaDh_PNT_N (PF05222, IPR007886, SM01003): Alanine dehydrogenase/PNT, N-terminal domain
PNTB (PF02233, IPR012136): NAD(P) transhydrogenase beta subunit
PNTB_4TM (PF12769, IPR024605): 4TM region of pyridine nucleotide transhydrogenase, mitoch
140 NOCTinteractor100Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
141 NPEPPSinteractor60.333175.183Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
142 NPLOC4interactor230.340117.139NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
143 NUP85interactor50.7003.134Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
144 OATinteractor50.8001.438Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
145 OLA1interactor50.20015.852Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
146 ORAI1interactor100Orai-1 (PF07856, IPR012446): Mediator of CRAC channel activity
147 OS9protein found in more fusions160.52429.783DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
148 OXA1Lprotein found in more fusions40.6670.47460KD_IMP (PF02096, IPR001708): 60Kd inner membrane protein
149 PCK1interactor110.27338.729PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
150 PEX11Binteractor31.0000PEX11 (PF05648, IPR008733): Peroxisomal biogenesis factor 11 (PEX11)
151 PEX19interactor90.30644.005Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
152 PFKLprotein found in more fusions90.5718.088PFK (PF00365, IPR000023): Phosphofructokinase
153 PFKPinteractor90.5009.318PFK (PF00365, IPR000023): Phosphofructokinase
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
154 PJA1interactor60.4009.569zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
155 PJA2protein found in more fusions100.47219.374zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
156 PNPLA2interactor100Patatin (PF01734, IPR002641): Patatin-like phospholipase
157 PNPLA6interactor21.0000Patatin (PF01734, IPR002641): Patatin-like phospholipase
PT (PF04886, IPR006970): PT repeat
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
158 POLD3interactor204.712CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
159 PPP2R1Bsuppressor80.14367.231HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
160 PRKACAinteractor190.322332.293Pkinase (PF00069, IPR000719): Protein kinase domain
161 PRKDCprotein found in more fusions170.292126.262FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
162 PSEN2oncoprotein80.38117.010Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
Presenilin (PF01080, IPR001108): Presenilin
163 PSMD2oncoprotein160.217117.740PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
164 PTGS2oncoprotein80.7144.027An_peroxidase (PF03098, IPR002007): Animal haem peroxidase
EGF (PF00008, IPR000742, SM00181): EGF-like domain
165 RAB5Concoprotein110.32741.154Ras (PF00071, IPR001806, SM00173): Ras family
166 RAB7Asuppressor220.221310.726Ras (PF00071, IPR001806, SM00173): Ras family
167 RAB9Aoncoprotein202.910Ras (PF00071, IPR001806, SM00173): Ras family
168 RBM14-RBM4interactor202.910RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
CompInhib_SCIN (PF11546, IPR021612): Staphylococcal complement inhibitor SCIN
ACC_epsilon (PF13822, IPR032716): Acyl-CoA carboxylase epsilon subunit
169 RGS20interactor100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
170 RNF126interactor170.30883.419Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zinc_ribbon_9 (PF14369): zinc-ribbon
171 RNF2interactor290.148504.514zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
172 RPTORprotein found in more fusions70.20057.920HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
173 RRM2interactor31.0000Ribonuc_red_sm (PF00268, IPR000358): Ribonucleotide reductase, small chain
174 S100A10oncoprotein40.6671.147S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
175 SAE1interactor60.267199.596ThiF (PF00899, IPR000594): ThiF family
176 SARAFprotein found in more fusions61.0000SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
177 SEL1Loncoprotein130.57716.109fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
178 SELENOSinteractor110.61810.630Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
DUF3326 (PF11805, IPR021763): Protein of unknown function (DUF3326)
179 SERPINH1interactor130.308133.433Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
180 SETDB1interactor60.26730.944MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
181 SH3GL1oncoprotein160.68613.984BAR (PF03114, IPR004148, SM00721): BAR domain
PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
182 SH3GLB1suppressor160.58171.409BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
183 SLC25A10interactor30.6670.143Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
184 SLC25A16interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
185 SLC25A22interactor50.6000.872Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
DUF4257 (PF14074, IPR025353): Protein of unknown function (DUF4257)
186 SLC25A24interactor30.6671.105Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
187 SLC25A4interactor40.5004.069Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
188 SLC26A6interactor100STAS (PF01740, IPR002645): STAS domain
Sulfate_transp (PF00916, IPR011547): Sulfate permease family
189 SORT1interactor40.5001.919Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3,
190 SPG7oncoprotein100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
AAA_22 (PF13401, IPR003593): AAA domain
191 SQLEinteractor100FAD_binding_3 (PF01494, IPR002938): FAD binding domain
SE (PF08491, IPR013698): Squalene epoxidase
CBP_BcsF (PF11120, IPR019995): Cellulose biosynthesis protein BcsF
192 STK17Binteractor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
193 STOMprotein found in more fusions90.35737.102Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
194 STT3Ainteractor60.4005.756STT3 (PF02516, IPR003674): Oligosaccharyl transferase STT3 subunit
195 SUCLA2interactor50.300242.080ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
nsp7 (PF08716, IPR014828): nsp7 replicase
196 SUCLG2interactor50.7002.390ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
197 SYVN1protein found in more fusions220.39069.074Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
198 TARBP1interactor21.0000SpoU_methylase (PF00588, IPR001537): SpoU rRNA Methylase family
199 TBCDinteractor21.0000HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
HEAT_EZ (PF13513): HEAT-like repeat
200 TCEB1oncoprotein60.6673.278Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
201 TCTN2interactor200.189132.140DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
202 THG1Linteractor120.67348.624Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
203 TIMM17Binteractor30.6671.000Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
204 TIMM23interactor50.5007.968Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
205 TIMM23Binteractor21.0000Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
206 TIMMDC1interactor70.57111.407Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
207 TM9SF3interactor30.6670.167EMP70 (PF02990, IPR004240): Endomembrane protein 70
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
DUF4231 (PF14015, IPR025325): Protein of unknown function (DUF4231)
208 TMED2interactor50.5008.705EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
209 TMED9interactor60.4678.628EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
210 TMEM159interactor21.0000IncA (PF04156, IPR007285): IncA protein
Promethin (PF16015): Promethin
211 TMEM43interactor40.8330.400TMEM43 (PF07787, IPR012430): Transmembrane protein 43
UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
212 TMEM55Binteractor100Tmemb_55A (PF09788, IPR019178): Transmembrane protein 55A
213 TOMM20interactor70.38122.110RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
214 TOMM22interactor90.41719.280Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
215 TOMM40interactor90.33318.935Porin_3 (PF01459, IPR027246): Eukaryotic porin
216 TPD52L2protein found in more fusions150.51662.048TPD52 (PF04201, IPR007327): Tumour protein D52 family
217 TPRKBinteractor140.560116.382CGI-121 (PF08617, IPR013926): Kinase binding protein CGI-121
218 TRA2Binteractor70.5713.784RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
219 TRAM1interactor30.6670.471TRAM1 (PF08390, IPR013599): TRAM1-like protein
TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
DUF3671 (PF12420, IPR022139): Protein of unknown function
220 TRMT10Aoncoprotein80.6799.560ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
tRNA_m1G_MT (PF01746, IPR016009): tRNA (Guanine-1)-methyltransferase
221 TROinteractor21.0000MAGE (PF01454, IPR002190): MAGE family
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
AP3D1 (PF06375): AP-3 complex subunit delta-1
222 TTC27interactor40.6670.733TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TraH (PF06122, IPR010927): Conjugative relaxosome accessory transposon protein
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
223 TUBA1Aoncoprotein170.353140.533Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
224 TUBA1Bprotein found in more fusions90.41717.813Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
225 TUBA1Cprotein found in more fusions250.293151.504Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
226 TUBA4Ainteractor160.43339.021Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
227 TUBB3interactor160.41751.980Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
228 TUBG1protein found in more fusions190.288240.318Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
229 UBAC2interactor210.210188.902Rhomboid (PF01694, IPR022764): Rhomboid family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
230 UBBinteractor100.42214.855ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
231 UBCprotein found in more fusions590.1521769.455ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
232 UBE2D1interactor190.34049.586UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
233 UBE2J1interactor130.50024.614UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
ATPase-cat_bd (PF12156, IPR021993): Putative metal-binding domain of cation transport ATPase
234 UBE3Aoncoprotein160.295156.404HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
235 UBE3Cprotein found in more fusions70.4673.983IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
236 UBL4Ainteractor280.259200.968ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
237 UBQLN2protein found in more fusions120.309176.683Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
238 UBR1interactor80.60712.033ATPase_2 (PF01637, IPR011579): ATPase domain predominantly from Archaea
ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
239 UBR2interactor41.0000ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
240 UBR4interactor80.6079.957CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
RecR (PF02132, IPR023628): RecR protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
DZR (PF12773, IPR025874): Double zinc ribbon
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
FAM176 (PF14851): FAM176 family
241 UBR5protein found in more fusions140.42340.322CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
242 UBXN1interactor300.333169.567Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
243 UBXN6interactor140.31991.050PUB (PF09409, IPR018997): PUB domain
UBX (PF00789, IPR001012, SM00166): UBX domain
244 UBXN7interactor240.341110.273UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
245 UFD1Linteractor230.352256.378UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
246 UNC45Ainteractor80.53610.218Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
TPR_16 (PF13432): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
247 UQCRC2oncoprotein170.30167.070Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
248 UQCRQinteractor100.31125.101UcrQ (PF02939, IPR004205): UcrQ family
249 USP13interactor110.61821.501UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
250 USP19interactor130.24449.434CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
251 VAPBinteractor150.257120.551ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
252 VCPprotein found in more fusions600.1771713.322AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
253 VCPIP1interactor100.6896.484ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C3H1 (PF10650, IPR019607, SM00356): Putative zinc-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SDP_N (PF12278, IPR022063): Sex determination protein N terminal
254 VDAC2interactor170.28776.765Porin_3 (PF01459, IPR027246): Eukaryotic porin
255 VDAC3interactor140.33044.397Porin_3 (PF01459, IPR027246): Eukaryotic porin
256 VMP1interactor31.0000SNARE_assoc (PF09335, IPR015414): SNARE associated Golgi protein
257 VPS13Ainteractor30.6670.518ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
DUF1493 (PF07377, IPR010862): Protein of unknown function (DUF1493)
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
VPS13_mid_rpt (PF16910, IPR031642): Repeating coiled region of VPS13
258 VPS13Cinteractor100ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
WWE (PF02825, IPR004170, SM00678): WWE domain
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
VPS13_mid_rpt (PF16910, IPR031642): Repeating coiled region of VPS13
259 VPS52interactor304.712Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
260 VRK2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
VP_N-CPKC (PF11475, IPR021573): Virion protein N terminal domain
261 WDR26interactor50.6003.160eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
262 XPO1interactor380.1081223.017CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
263 XPR1interactor50.50023.312EXS (PF03124, IPR004342): EXS family
SPX (PF03105, IPR004331): SPX domain
264 YES1oncoprotein50.30026.461Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
265 YIPF5interactor60.6004.508Yip1 (PF04893, IPR006977): Yip1 domain
266 YOD1interactor110.6369.516OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
267 ZFAND2Binteractor70.5713.803UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger

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