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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FRMD4B, MARCH8 (from a repository: Wed Jun 19 01:52:29 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins2 (18.18 %)
The number (and %) of the tumor suppressors1 (9.09 %)
Total number of binary PPIs (saturation %)14 (25.45 %)
The number (and %) of affected PPIs9 (64.29 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI1.818
Assortativity coefficient-0.1756
The network average Clustering coefficient0.185
The number (and %) of a zero Clustering coefficients8 (72.73 %)
The number (and %) of a zero Betweenness Centrality10 (90.91 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MARCH8,FRMD4B All fusions
Proteins found in more fusions UBE2H (see 4 fusions); TFRC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MARCH8parental protein80.03654.000DctQ (PF04290, IPR007387): Tripartite ATP-independent periplasmic transporters, DctQ component
RINGv (PF12906, IPR011016, SM00744): RING-variant domain
2 FRMD4Bparental protein100FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Med30 (PF11315, IPR021019): Mediator complex subunit 30
DUF3338 (PF11819, IPR021774): Domain of unknown function (DUF3338)
3 CD86interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
LAX (PF15681, IPR031393): Lymphocyte activation family X
4 IL1R1interactor21.0000TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
5 IL1RAPinteractor21.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
6 TFRConcoprotein200PA (PF02225, IPR003137): PA domain
Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
DUF3855 (PF12967, IPR024482): Domain of Unknown Function with PDB structure (DUF3855)
7 TNFRSF10Asuppressor100Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMIE (PF16038, IPR032006): TMIE protein
8 UBE2D1interactor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
9 UBE2D3interactor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
10 UBE2Hprotein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
11 XPO1interactor100CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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