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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins XIST, ARHGAP26 (from a repository: Sun Sep 16 16:10:17 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins2 (12.50 %)
The number (and %) of the tumor suppressors4 (25.00 %)
Total number of binary PPIs (saturation %)27 (22.50 %)
The number (and %) of affected PPIs14 (51.85 %)
The number of possible different fusions2
PPI diameter5
PPI radius3
The average degree of PPI2.750
Assortativity coefficient-0.5256
The network average Clustering coefficient0.472
The number (and %) of a zero Clustering coefficients4 (25.00 %)
The number (and %) of a zero Betweenness Centrality9 (56.25 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: XIST,ARHGAP26 All fusions
Proteins found in more fusions PTK2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 XISTparental protein50.30025.333NA
2 ARHGAP26parental protein90.083143.000Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
SH3_9 (PF14604, IPR001452): Variant SH3 domain
BAR_3 (PF16746): BAR domain of APPL family
3 ACADSinteractor100Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 BARD1suppressor40.33343.333BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
5 BRCA1suppressor40.6677.667BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6 C2CD2interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF2057 (PF09829, IPR018635): Uncharacterized protein conserved in bacteria (DUF2057)
7 CDC42oncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
8 CDC42EP2interactor21.0000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
9 HIST2H3Cinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
10 MAGOHinteractor30.33336.667Mago_nashi (PF02792, IPR004023): Mago nashi protein
11 NXF1interactor31.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
12 PKN3interactor100HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
13 PTENsuppressor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
14 PTK2protein found in more fusions40.6677.000FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
15 RHOAsuppressor100Ras (PF00071, IPR001806, SM00173): Ras family
16 SRPK1interactor40.167109.000FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1

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