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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FGF1, ARHGAP26 (from a repository: Sat Jan 7 18:40:25 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins15 (42.86 %)
The number (and %) of the tumor suppressors3 (8.57 %)
Total number of binary PPIs (saturation %)71 (11.93 %)
The number (and %) of affected PPIs34 (47.89 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI3.143
Assortativity coefficient-0.2889
The network average Clustering coefficient0.381
The number (and %) of a zero Clustering coefficients17 (48.57 %)
The number (and %) of a zero Betweenness Centrality25 (71.43 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FGF1,ARHGAP26 All fusions
Proteins found in more fusions KDM1A (see 2 fusions); FGFR2 (see 3 fusions); SDC2 (see 2 fusions); CSNK2A1 (see 1 fusions); RCOR1 (see 2 fusions); HMG20A (see 1 fusions); PTK2 (see 2 fusions); GSE1 (see 1 fusions); S100A13 (see 1 fusions); FGFR1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FGF1parental protein250.054815.333FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
2 ARHGAP26parental protein90.083390.000Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
SH3_9 (PF14604, IPR001452): Variant SH3 domain
BAR_3 (PF16746): BAR domain of APPL family
3 ACADSinteractor100Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 C2CD2interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF2057 (PF09829, IPR018635): Uncharacterized protein conserved in bacteria (DUF2057)
5 CDC42oncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
6 CDC42EP2interactor21.0000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
7 CLDN10interactor100PMP22_Claudin (PF00822, IPR004031): PMP-22/EMP/MP20/Claudin family
DUF4064 (PF13273, IPR025273): Protein of unknown function (DUF4064)
8 CSNK2A1oncoprotein60.600117.333Pkinase (PF00069, IPR000719): Protein kinase domain
9 CSNK2A2interactor60.467140.333Pkinase (PF00069, IPR000719): Protein kinase domain
10 CSNK2Binteractor41.0000CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
11 EGFLAMinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
12 FGFBP1interactor200FGF-BP1 (PF06473, IPR010510): FGF binding protein 1 (FGF-BP1)
13 FGFR1oncoprotein200I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
14 FGFR2oncoprotein200Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
15 FGFR3oncoprotein200I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
16 FGFR4oncoprotein200APH (PF01636, IPR002575): Phosphotransferase enzyme family
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
17 FIBPinteractor100FIBP (PF05427, IPR008614): Acidic fibroblast growth factor binding (FIBP)
18 GPC1interactor2083.333Glypican (PF01153, IPR001863): Glypican
19 GPC6interactor100Glypican (PF01153, IPR001863): Glypican
20 GSE1oncoprotein51.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
DUF3736 (PF12540, IPR022207): Protein of unknown function (DUF3736)
AAA_11 (PF13086): AAA domain
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
21 HMG20Aprotein found in more fusions60.8001.333DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
MlaC (PF05494, IPR008869): MlaC protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
22 HSPA9oncoprotein100HSP70 (PF00012, IPR013126): Hsp70 protein
23 KDM1Aprotein found in more fusions80.52436.000Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
24 PKN3interactor100HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
25 PTENsuppressor60.133455.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
26 PTK2protein found in more fusions40.66726.000FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
27 RCOR1protein found in more fusions41.0000DivIC (PF04977, IPR007060): Septum formation initiator
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
FAM76 (PF16046, IPR032017): FAM76 protein
28 RCOR3interactor41.0000ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
29 RHOAsuppressor100Ras (PF00071, IPR001806, SM00173): Ras family
30 S100A13oncoprotein31.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
31 SDC2protein found in more fusions31.0000Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
32 SDC4oncoprotein2083.333Syndecan (PF01034, IPR027789): Syndecan domain
33 SRPK1interactor21.0000FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
34 SYT1interactor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Comm (PF15957, IPR031878): Commissureless
35 TGFBR3suppressor100Delta_lysin (PF05372, IPR008034): Delta lysin family
Zona_pellucida (PF00100, IPR001507, SM00241): Zona pellucida-like domain

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