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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SETX, BEX1 (from a repository: Mon Sep 16 05:24:53 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins7 (17.95 %)
The number (and %) of the tumor suppressors9 (23.08 %)
Total number of binary PPIs (saturation %)85 (11.47 %)
The number (and %) of affected PPIs38 (44.71 %)
The number of possible different fusions6
PPI diameter4
PPI radius2
The average degree of PPI3.436
Assortativity coefficient-0.3136
The network average Clustering coefficient0.386
The number (and %) of a zero Clustering coefficients17 (43.59 %)
The number (and %) of a zero Betweenness Centrality23 (58.97 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: BEX1,SETX All fusions
: AA910636;
Proteins found in more fusions FGFR2 (see 3 fusions); POLR2A (see 2 fusions); CLU (see 5 fusions); SMAD4 (see 2 fusions); GSK3B (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BEX1parental protein150.038550.795BEX (PF04538, IPR021156): Brain expressed X-linked like family
2 SETXparental protein230.083899.238ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
3 ALBinteractor21.0000Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 APOA1interactor40.6671.000ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
5 BAG4interactor100BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
6 BCAR3oncoprotein100RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
7 BRCA1suppressor100.306143.638BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
8 CARD8oncoprotein100CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
FIIND (PF13553, IPR025307): Function to find
9 CASP8suppressor31.0000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
10 CDC5Linteractor40.6671.667OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
11 CHEK2suppressor3031.486FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
12 CLUsuppressor31.0000Clusterin (PF01093, IPR000753): Clusterin
13 CNTROBinteractor100DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
FadA (PF09403, IPR018543): Adhesion protein FadA
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
14 COMTD1interactor100FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
15 FBXW7suppressor40.66719.205Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
16 FGFR2oncoprotein200Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
17 FZR1suppressor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
18 GSK3Bsuppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
19 ISLRinteractor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
20 LCN15interactor100Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
21 MDFIinteractor200MDFI (PF15316, IPR026134): MyoD family inhibitor
22 MEF2Aoncoprotein21.0000TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
23 MLST8interactor100Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
24 OMPinteractor100Olfactory_mark (PF06554, IPR009103): Olfactory marker protein
25 PAX2oncoprotein2031.486PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax2_C (PF12403, IPR022130): Paired-box protein 2 C terminal
26 PIK3CAoncoprotein100PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
27 PNKDinteractor100Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
28 POLR2Aprotein found in more fusions70.6677.500RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
29 POLR2Finteractor41.0000RNA_pol_Rpb6 (PF01192, IPR006110): RNA polymerase Rpb6
30 POLR2Ginteractor60.9001.500SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
31 PTENsuppressor60.267445.476DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
32 SKAP1interactor200PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
33 SMAD4suppressor40.33346.552MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
34 SMN1interactor40.6671.000SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
35 SUMO1interactor60.50033.000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
36 SUMO2interactor41.0000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
37 SUPT5Hinteractor50.9001.500KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
38 TEX11interactor100SPO22 (PF08631, IPR013940): Meiosis protein SPO22/ZIP4 like
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2547 (PF10818, IPR020508): Protein of unknown function (DUF2547)
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
AAA_28 (PF13521): AAA domain
TPR_19 (PF14559): Tetratricopeptide repeat
39 UBE2Iinteractor80.38160.957UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ALBinteractorSerum_albumin (PF00273, IPR014760, SM00103): Serum albumin familyAA910636
2 BAG4interactorBAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
AA910636
3 BCAR3oncoproteinRasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
AA910636
4 BEX1parental proteinBEX (PF04538, IPR021156): Brain expressed X-linked like familyAA910636
5 BRCA1suppressorBRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
AA910636
6 CARD8oncoproteinCARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
FIIND (PF13553, IPR025307): Function to find
AA910636
7 CLUsuppressorClusterin (PF01093, IPR000753): ClusterinAA910636
8 COMTD1interactorFoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1AA910636
9 FBXW7suppressorMem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
AA910636
10 FGFR2oncoproteinHerpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
AA910636
11 GSK3BsuppressorPkinase (PF00069, IPR000719): Protein kinase domainAA910636
12 LCN15interactorLipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein familyAA910636
13 MDFIinteractorMDFI (PF15316, IPR026134): MyoD family inhibitorAA910636
14 MEF2AoncoproteinTFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
AA910636
15 MLST8interactorHira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
AA910636
16 OMPinteractorOlfactory_mark (PF06554, IPR009103): Olfactory marker proteinAA910636
17 PAX2oncoproteinPAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax2_C (PF12403, IPR022130): Paired-box protein 2 C terminal
AA910636
18 PIK3CAoncoproteinPI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
AA910636
19 PNKDinteractorLactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
AA910636
20 POLR2FinteractorRNA_pol_Rpb6 (PF01192, IPR006110): RNA polymerase Rpb6AA910636
21 SETXparental proteinResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
AA910636
22 SKAP1interactorPH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
AA910636
23 SMAD4suppressorMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
AA910636
24 SMN1interactorSMN (PF06003, IPR010304): Survival motor neuron protein (SMN)AA910636
25 SUMO1interactorRad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-likeAA910636
26 SUMO2interactorRad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-likeAA910636
27 SUPT5HinteractorKOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
AA910636
28 TEX11interactorSPO22 (PF08631, IPR013940): Meiosis protein SPO22/ZIP4 like
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2547 (PF10818, IPR020508): Protein of unknown function (DUF2547)
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
AAA_28 (PF13521): AAA domain
TPR_19 (PF14559): Tetratricopeptide repeat
AA910636
29 UBE2IinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzymeAA910636

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