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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PDZD2, BTN3A2 (from a repository: Thu Aug 22 01:35:33 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins5 (29.41 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)24 (17.65 %)
The number (and %) of affected PPIs15 (62.50 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.235
Assortativity coefficient-0.2092
The network average Clustering coefficient0.249
The number (and %) of a zero Clustering coefficients11 (64.71 %)
The number (and %) of a zero Betweenness Centrality13 (76.47 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BTN3A2,PDZD2 All fusions
Proteins found in more fusions ERBIN (see 7 fusions); PRPF40A (see 2 fusions); MYC (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BTN3A2parental protein4012.000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
MHC2-interact (PF09307, IPR015386): CLIP, MHC2 interacting
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
2 PDZD2parental protein110.07398.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
3 ADGRB1interactor2007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
GAIN (PF16489, IPR032471): GPCR-Autoproteolysis INducing (GAIN) domain
4 ATP5G1interactor100ATP-synt_C (PF00137, IPR002379): ATP synthase subunit C
5 BTN3A1interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
6 BTN3A3interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
7 CTNND2oncoprotein100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
8 DDX24interactor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tti2 (PF10521, IPR018870): Tti2 family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
9 ERBINoncoprotein40.6671.000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
10 MYConcoprotein50.5003.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
11 NRXN1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Syndecan (PF01034, IPR027789): Syndecan domain
12 NUP35interactor100Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
13 PEX13interactor200Peroxin-13_N (PF04088, IPR007223): Peroxin 13, N-terminal region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
14 PKP4interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
15 PRPF40Aprotein found in more fusions200FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
16 PTOV1interactor100Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2
17 RAD21oncoprotein21.0000Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box

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