Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SEPT9, TRAPPC8 (from a repository: Mon Aug 26 22:13:47 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)71
The number (and %) of the onco-proteins17 (23.94 %)
The number (and %) of the tumor suppressors8 (11.27 %)
Total number of binary PPIs (saturation %)326 (13.12 %)
The number (and %) of affected PPIs71 (21.78 %)
The number of possible different fusions15
PPI diameter4
PPI radius2
The average degree of PPI8.338
Assortativity coefficient-0.1898
The network average Clustering coefficient0.584
The number (and %) of a zero Clustering coefficients3 (4.23 %)
The number (and %) of a zero Betweenness Centrality14 (19.72 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SEPTIN9,TRAPPC8 All fusions
Proteins found in more fusions HNRNPD (see 1 fusions); TRAPPC10 (see 1 fusions); APP (see 5 fusions); COPA (see 1 fusions); SH3KBP1 (see 1 fusions); U2AF2 (see 2 fusions); TRAPPC11 (see 1 fusions); TRAPPC8 (see 1 fusions); TPM3 (see 3 fusions); MSH2 (see 1 fusions); NEDD4 (see 1 fusions); NCL (see 4 fusions); NTRK1/TPM3 (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SEPT9parental protein530.1172496.159Septin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
2 TRAPPC8parental protein180.346343.651TRAPPC-Trs85 (PF12739, IPR024420): ER-Golgi trafficking TRAPP I complex 85 kDa subunit
SNAP (PF14938): Soluble NSF attachment protein, SNAP
3 ACAT2interactor31.0000Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ANLNoncoprotein100.44418.541Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
5 APPprotein found in more fusions150.165534.254APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 BARD1suppressor60.20027.567BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
7 CDC42EP4interactor70.76217.338PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
8 CDC5Linteractor150.52745.993OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
9 CFTRsuppressor80.38111.919ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
10 COPAprotein found in more fusions110.42244.816Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
COPI_C (PF06957, IPR010714): Coatomer (COPI) alpha subunit C-terminus
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
11 DDA1interactor21.0000DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
12 EEDsuppressor90.7502.424WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
13 FERMT2interactor50.50012.091FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
14 FLNBoncoprotein50.5002.022CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
15 FN1oncoprotein120.24238.742fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
16 HAUS1interactor31.0000THP2 (PF09432, IPR018557): Tho complex subunit THP2
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
17 HIF1Asuppressor21.0000Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
18 HNRNPDoncoprotein110.62212.674CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
19 HSPA5oncoprotein150.61526.330HSP70 (PF00012, IPR013126): Hsp70 protein
20 HSPD1suppressor130.48764.997Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
21 IKBKGinteractor31.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
22 JPT1interactor206.160JUPITER (PF17054): Microtubule-Associated protein Jupiter
23 MSH2suppressor70.60021.405MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
24 NCLprotein found in more fusions90.50021.743DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
25 NDUFV2interactor50.4005.0002Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
26 NEDD4suppressor40.6674.447Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
27 NTRK1oncoprotein250.207977.755I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
28 OBSL1interactor150.39636.419BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
29 PAXIP1interactor60.13337.625BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
30 RIDAinteractor31.0000Ribonuc_L-PSP (PF01042, IPR006175): Endoribonuclease L-PSP
31 SCO2interactor50.50016.882SCO1-SenC (PF02630, IPR003782): SCO1/SenC
32 SCP2interactor40.6672.498SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family
Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
33 SEC22Binteractor80.28617.556Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
34 SEPT1interactor80.76217.338Pet20 (PF08692, IPR014804): Mitochondrial protein Pet20
Septin (PF00735, IPR000038): Septin
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
35 SEPT11interactor120.43929.319Septin (PF00735, IPR000038): Septin
DUF3080 (PF11279, IPR021431): Protein of unknown function (DUF3080)
36 SEPT2oncoprotein170.44981.464FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
37 SEPT3interactor80.9520.286Septin (PF00735, IPR000038): Septin
38 SEPT6oncoprotein130.50023.302Septin (PF00735, IPR000038): Septin
DUF2959 (PF11172, IPR021342): Protein of unknown function (DUF2959)
39 SEPT7interactor150.51431.405Fez1 (PF06818): Fez1
Septin (PF00735, IPR000038): Septin
40 SH3KBP1protein found in more fusions80.8102.574Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
41 SNW1protein found in more fusions160.54346.929SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
42 SRRM2interactor170.390161.194cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
43 STK11suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
44 SUCLG1interactor30.6670.667CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
CoA_binding_2 (PF13380, IPR003781): CoA binding domain
45 SUCLG2interactor40.5002.167ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
46 SVILinteractor40.5002.667Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
47 TECPR1interactor31.0000DUF1768 (PF08719, IPR012816): Domain of unknown function (DUF1768)
Pex24p (PF06398, IPR010482): Integral peroxisomal membrane peroxin
PH (PF00169, IPR001849, SM00233): PH domain
Hyd_WA (PF06462, IPR006624, SM00706): Propeller
48 TIMM44interactor40.6678.395Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
RecG_N (PF17190): RecG N-terminal helical domain
49 TMED9interactor30.6670.500EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
50 TOR1AIP1interactor21.0000LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C)
Pap_E4 (PF02711, IPR003861): E4 protein
51 TPM3oncoprotein70.26723.341Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
52 TRAPPC10protein found in more fusions90.9290.508Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1
TRAPPC10 (PF12584, IPR022233): Trafficking protein particle complex subunit 10, TRAPPC10
53 TRAPPC11protein found in more fusions110.53398.541DUF974 (PF06159, IPR010378): Protein of unknown function (DUF974)
Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1
Gryzun-like (PF12742, IPR025876): Gryzun, putative Golgi trafficking
54 TRAPPC12interactor140.577171.426TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
55 TRAPPC13interactor41.0000DUF974 (PF06159, IPR010378): Protein of unknown function (DUF974)
Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Trs65 (PF12735, IPR024662): TRAPP trafficking subunit Trs65
56 TRAPPC2interactor100.8062.143Sedlin_N (PF04628, IPR006722): Sedlin, N-terminal conserved region
57 TRAPPC2Linteractor120.63670.375Sedlin_N (PF04628, IPR006722): Sedlin, N-terminal conserved region
58 TRAPPC3interactor90.66755.119TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
59 TRAPPC3Linteractor90.8611.413TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
60 TRAPPC4interactor120.72759.983Sybindin (PF04099, IPR007233): Sybindin-like family
61 TRAPPC6Binteractor80.8930.841TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
62 TRAPPC9interactor90.667104.208PMBR (PF09373, IPR018975): Pseudomurein-binding repeat
TRAPPC9-Trs120 (PF08626, IPR013935): Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
Vps23_core (PF09454, IPR017916): Vps23 core domain
63 U2AF2protein found in more fusions150.60450.537RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
64 UBXN6interactor30.6671.905PUB (PF09409, IPR018997): PUB domain
UBX (PF00789, IPR001012, SM00166): UBX domain
65 UNKinteractor70.09563.981MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
66 UQCRFS1interactor21.0000Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
67 UQCRFS1P1interactor100NA
68 VAMP2interactor31.0000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
PRIMA1 (PF16101): Proline-rich membrane anchor 1
69 VAPBinteractor50.50032.078ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
70 VMA21interactor100VMA21 (PF09446, IPR019013): VMA21-like domain
71 XPO1interactor130.26998.387CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k    t o    T o p ⇑