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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CYP19A1, PLEKHA6 (from a repository: Mon Jun 1 03:33:18 2020)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins4 (50.00 %)
The number (and %) of the tumor suppressors1 (12.50 %)
Total number of binary PPIs (saturation %)13 (46.43 %)
The number (and %) of affected PPIs6 (46.15 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.250
Assortativity coefficient-0.4898
The network average Clustering coefficient0.463
The number (and %) of a zero Clustering coefficients3 (37.50 %)
The number (and %) of a zero Betweenness Centrality6 (75.00 %)


List of the fusions

PPI for parental proteins: PLEKHA6,CYP19A1 All fusions
Proteins found in more fusions PLEKHA5 (see 1 fusions); APOE (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 PLEKHA6parental protein60.20021.000FliJ (PF02050, IPR012823): Flagellar FliJ protein
PH (PF00169, IPR001849, SM00233): PH domain
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
2 CYP19A1oncoprotein000p450 (PF00067, IPR001128): Cytochrome P450
3 APOEprotein found in more fusions200Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
4 CFTRsuppressor31.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
5 MYBPHLinteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
6 NTRK1oncoprotein31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
7 PLEKHA5protein found in more fusions31.0000PH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
8 XPO1interactor40.5003.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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