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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PLEKHA6, BCL2L11 (from a repository: Fri Jul 26 14:24:22 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)51
The number (and %) of the onco-proteins15 (29.41 %)
The number (and %) of the tumor suppressors8 (15.69 %)
Total number of binary PPIs (saturation %)163 (12.78 %)
The number (and %) of affected PPIs49 (30.06 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI5.490
Assortativity coefficient-0.2256
The network average Clustering coefficient0.421
The number (and %) of a zero Clustering coefficients10 (19.61 %)
The number (and %) of a zero Betweenness Centrality16 (31.37 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PLEKHA6,BCL2L11 All fusions
Proteins found in more fusions APOE (see 1 fusions); APP (see 5 fusions); MCL1 (see 2 fusions); AURKA (see 1 fusions); BAG3 (see 4 fusions); SMARCB1 (see 12 fusions); BCL2L1 (see 1 fusions); VHL (see 1 fusions); UBQLN2 (see 3 fusions); RACK1 (see 3 fusions); PLEKHA5 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PLEKHA6parental protein60.200122.611FliJ (PF02050, IPR012823): Flagellar FliJ protein
PH (PF00169, IPR001849, SM00233): PH domain
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
2 BCL2L11parental protein430.0761686.361Bclx_interact (PF08945, IPR015040): Bcl-x interacting, BH3 domain
Bim_N (PF06773, IPR014771): Bim protein N-terminus
3 ANKLE2interactor30.33312.719Cauli_VI (PF01693, IPR011320): Caulimovirus viroplasmin
LEM (PF03020, IPR003887, SM00540): LEM domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
4 APOEprotein found in more fusions3012.899Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
5 APPprotein found in more fusions140.20573.964APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ATP2A3interactor21.0000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
7 ATP6V1G1interactor21.0000V-ATPase_G (PF03179): Vacuolar (H+)-ATPase G subunit
8 AURKAoncoprotein70.46724.638Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
9 AURKBinteractor70.40051.260Pkinase (PF00069, IPR000719): Protein kinase domain
10 BAG3oncoprotein90.57111.551BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
11 BAXsuppressor120.41837.394Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
12 BCL2oncoprotein100.47219.277Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
13 BCL2A1oncoprotein30.6670.400Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
14 BCL2L1oncoprotein90.57110.674Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
15 BCL2L2oncoprotein21.0000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator
16 BTKsuppressor40.6670.667BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
17 BTRConcoprotein60.5004.267WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
18 CD302interactor100UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
19 CFTRsuppressor60.20034.896ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
20 CISHinteractor41.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
ER-remodelling (PF14755, IPR032786): Intracellular membrane remodeller
SOCS_box (PF07525, IPR001496): SOCS box
21 CUL2suppressor80.42928.162Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
22 DYNLL1interactor60.5006.770Dynein_light (PF01221, IPR001372): Dynein light chain type 1
23 DYNLL2interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
24 EDNRAinteractor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
25 FBXW11interactor70.5335.167WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
26 FEM1Cinteractor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
TPR_12 (PF13424): Tetratricopeptide repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
27 FGL1interactor21.0000Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
28 GIMAP5interactor50.7001.733AIG1 (PF04548, IPR006703): AIG1 family
KapB (PF08810, IPR014916): Kinase associated protein B
29 GTF2Iinteractor40.33315.775GTF2I (PF02946, IPR004212): GTF2I-like repeat
30 HSPA4interactor90.27868.077Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
31 KIF22interactor100Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
HHH_3 (PF12836): Helix-hairpin-helix motif
32 MAGEA11interactor200MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
33 MAPK8oncoprotein50.6671.333DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
34 MCL1oncoprotein90.50016.430Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
35 MTHFRoncoprotein100MTHFR (PF02219, IPR003171): Methylenetetrahydrofolate reductase
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
36 MYBPHLinteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
37 NDRG1suppressor40.33314.968Ndr (PF03096, IPR004142): Ndr family
38 NTRK1oncoprotein110.044140.265I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
39 PLEKHA5protein found in more fusions50.33319.744PH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
40 RACK1suppressor110.31165.709WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
41 RHPN2interactor100BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
42 RIOK3interactor30.33312.222RIO1 (PF01163, IPR018934): RIO1 family
43 SMARCB1suppressor40.33314.395SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
44 TCEB2interactor60.66721.749ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
45 TRIM2interactor100Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Caskin-tail (PF16632, IPR032117): C-terminal region of Caskin
DUF5128 (PF17170): 6-bladed beta-propeller
46 UBQLN2protein found in more fusions306.386Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
47 USP27Xinteractor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ISG65-75 (PF11727, IPR021057): Invariant surface glycoprotein
48 VDAC1interactor80.464110.031Porin_3 (PF01459, IPR027246): Eukaryotic porin
49 VHLsuppressor80.5247.667Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
50 XPO1interactor90.13977.865CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
51 YWHABinteractor80.32171.97614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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