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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GPC5, ZNF133 (from a repository: Thu Nov 21 23:55:24 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)10
The number (and %) of the onco-proteins4 (40.00 %)
The number (and %) of the tumor suppressors1 (10.00 %)
Total number of binary PPIs (saturation %)18 (40.00 %)
The number (and %) of affected PPIs8 (44.44 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.200
Assortativity coefficient-0.2556
The network average Clustering coefficient0.348
The number (and %) of a zero Clustering coefficients5 (50.00 %)
The number (and %) of a zero Betweenness Centrality7 (70.00 %)


List of the fusions

PPI for parental proteins: GPC5,ZNF133 All fusions
Proteins found in more fusions ILK (see 2 fusions); TRIM28 (see 1 fusions); FOS (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 GPC5parental protein100Glypican (PF01153, IPR001863): Glypican
2 ZNF133parental protein70.14334.000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
3 DCPSinteractor100DcpS (PF05652, IPR008594): Scavenger mRNA decapping enzyme (DcpS) N-terminal
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
4 FOSoncoprotein200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
5 ILKsuppressor40.6671.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
6 KRTAP10-7interactor200Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
7 MAPK6oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
8 MDM2oncoprotein31.0000Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
9 PDPK1interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
PH_3 (PF14593): PH domain
10 TRIM28protein found in more fusions40.6671.000ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2

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