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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins JAZF1, ALCAM (from a repository: Mon Aug 5 09:18:53 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins5 (35.71 %)
The number (and %) of the tumor suppressors2 (14.29 %)
Total number of binary PPIs (saturation %)25 (27.47 %)
The number (and %) of affected PPIs12 (48.00 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI2.714
Assortativity coefficient-0.2932
The network average Clustering coefficient0.549
The number (and %) of a zero Clustering coefficients3 (21.43 %)
The number (and %) of a zero Betweenness Centrality9 (64.29 %)


List of the fusions

PPI for parental proteins: ALCAM,JAZF1 All fusions
Proteins found in more fusions EGFR (see 2 fusions); LGALS3 (see 2 fusions); RXRA (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ALCAMparental protein70.19060.000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4366 (PF14283, IPR025376): Domain of unknown function (DUF4366)
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
2 JAZF1parental protein50.20064.000ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger
3 ART3interactor100ART (PF01129, IPR000768): NAD:arginine ADP-ribosyltransferase
4 CD6oncoprotein100SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
TMEM154 (PF15102, IPR028064): TMEM154 protein family
5 EGFRoncoprotein60.30087.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
6 LGALS3oncoprotein40.6677.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
7 LGALS8interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
8 LGALS9interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
9 NR2C2suppressor200Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
10 NTRK1oncoprotein31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
11 PPARGsuppressor40.33380.000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
12 RXRAoncoprotein31.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
13 TRRAPinteractor21.0000BALF1 (PF06861, IPR010677): BALF1 protein
BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
ACDC (PF14733, IPR028078): AP2-coincident C-terminal
14 YEATS4interactor21.0000YEATS (PF03366, IPR005033): YEATS family
SOGA (PF11365, IPR027881): Protein SOGA

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