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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FCGRT, ALCAM (from a repository: Sat Jan 7 00:12:40 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins5 (31.25 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)24 (20.00 %)
The number (and %) of affected PPIs14 (58.33 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.375
Assortativity coefficient-0.4302
The network average Clustering coefficient0.400
The number (and %) of a zero Clustering coefficients7 (43.75 %)
The number (and %) of a zero Betweenness Centrality12 (75.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ALCAM,FCGRT All fusions
Proteins found in more fusions EGFR (see 2 fusions); HLA-B (see 2 fusions); LGALS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ALCAMparental protein70.19030.000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4366 (PF14283, IPR025376): Domain of unknown function (DUF4366)
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
2 FCGRTparental protein70.04840.000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
3 A4GALTinteractor100Gb3_synth (PF04572, IPR007652): Alpha 1,4-glycosyltransferase conserved region
Gly_transf_sug (PF04488, IPR007577): Glycosyltransferase sugar-binding region containing DXD motif
4 ALBinteractor100Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
5 ART3interactor100ART (PF01129, IPR000768): NAD:arginine ADP-ribosyltransferase
6 ATG16L1interactor200ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2332 (PF10094, IPR011200): Uncharacterized protein conserved in bacteria (DUF2332)
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
7 ATP1B4interactor100Gcd10p (PF04189, IPR007316): Gcd10p family
Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
8 CD1Binteractor100C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
MLANA (PF14991, IPR029242): Protein melan-A
MHC_I_3 (PF16497, IPR011161): MHC-I family domain
9 CD6oncoprotein100SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
TMEM154 (PF15102, IPR028064): TMEM154 protein family
10 EGFRoncoprotein50.5003.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
11 HLA-Boncoprotein31.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
12 HLA-Einteractor21.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
13 LGALS3oncoprotein40.6671.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
14 LGALS8interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
15 LGALS9interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
16 NTRK1oncoprotein31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain

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