Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins FANCB, PSMB1 (from a repository: Fri Aug 2 18:10:14 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 129 The number (and %) of the onco-proteins 30 (23.26 %) The number (and %) of the tumor suppressors 12 (9.30 %) Total number of binary PPIs (saturation %) 1555 (18.83 %) The number (and %) of affected PPIs 128 (8.23 %) The number of possible different fusions 21 PPI diameter 4 PPI radius 2 The average degree of PPI 23.302 Assortativity coefficient -0.1408 The network average Clustering coefficient 0.690 The number (and %) of a zero Clustering coefficients 6 (4.65 %) The number (and %) of a zero Betweenness Centrality 22 (17.05 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: FANCB,PSMB1	All fusions
Proteins found in more fusions	EXOSC6 (see 1 fusions); PSMB3 (see 1 fusions); FANCL (see 2 fusions); PARK2 (see 1 fusions); VHL (see 1 fusions); MYC (see 2 fusions); PSME3 (see 2 fusions); PSMB7 (see 2 fusions); PSMA7 (see 5 fusions); FANCA (see 1 fusions); UBC (see 7 fusions); FANCG (see 1 fusions); SRSF2 (see 1 fusions); SYVN1 (see 1 fusions); RPL5 (see 1 fusions); BAG3 (see 4 fusions); FKBP8 (see 1 fusions); MCM2 (see 1 fusions); EPAS1 (see 1 fusions); PSMC5 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	FANCB	parental protein	9	0.778	254.000	DP (PF08781, IPR014889, SM01138): Transcription factor DP
2	PSMB1	parental protein	119	0.191	7360.957	Proteasome (PF00227, IPR001353): Proteasome subunit
3	ADRM1	interactor	40	0.908	7.869	Proteasom_Rpn13 (PF04683, IPR006773): Proteasome complex subunit Rpn13 ubiquitin receptor GET2 (PF08690, IPR028143): GET complex subunit GET2 RPN13_C (PF16550, IPR032368): UCH-binding domain
4	AMFR	oncoprotein	25	0.732	26.758	CUE (PF02845, IPR003892, SM00546): CUE domain UbiA (PF01040, IPR000537): UbiA prenyltransferase family zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
5	AP3M1	interactor	7	1.000	0	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
6	ASNA1	interactor	8	0.929	0.218	ArsA_ATPase (PF02374, IPR025723): Anion-transporting ATPase
7	BAG3	oncoprotein	26	0.707	39.284	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
8	BCL3	oncoprotein	1	0	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
9	CASP4	interactor	1	0	0	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
10	CCT5	interactor	13	0.397	26.392	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11	CDKN1B	suppressor	3	0.667	0.236	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
12	CENPS	suppressor	8	1.000	0	CENP-S (PF15630, IPR029003): CENP-S protein COMMD1_N (PF17221): COMMD1 N-terminal domain
13	CFTR	suppressor	10	0.861	0.497	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
14	CLIC4	oncoprotein	8	0.821	1.840	GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
15	DCP2	interactor	1	0	0	DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain NUDIX (PF00293, IPR000086): NUDIX domain
16	DDB2	suppressor	7	0.600	4.037	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
17	DSTYK	interactor	2	1.000	0	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
18	EPAS1	suppressor	7	0.667	2.800	Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1 PAS_11 (PF14598): PAS domain
19	EXOSC6	protein found in more fusions	7	1.000	0	RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
20	FAAP100	interactor	8	1.000	0	FANCAA (PF15146, IPR029251): Fanconi anemia-associated
21	FAAP20	interactor	9	0.778	233.265	UBZ_FAAP20 (PF15750, IPR031490): Ubiquitin-binding zinc-finger FANCA_interact (PF15751, IPR031491): FAAP20 FANCA interaction domain
22	FAAP24	interactor	8	1.000	0	Rad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_2 (PF12826): Helix-hairpin-helix motif
23	FANCA	oncoprotein	10	0.778	323.758	Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
24	FANCG	suppressor	10	0.778	864.408	BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain Hpt (PF01627, IPR008207, SM00073): Hpt domain TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
25	FANCL	protein found in more fusions	10	0.806	15.536	WD-3 (PF09765, IPR019162): WD-repeat region FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
26	FANCM	interactor	11	0.667	47.857	ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain MRC1 (PF09444, IPR018564): MRC1-like domain ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain HHH_2 (PF12826): Helix-hairpin-helix motif FANCM-MHF_bd (PF16783, IPR031879): FANCM to MHF binding domain
27	FBXO28	interactor	5	0.400	4.015	Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit F-box (PF00646, IPR001810, SM00256): F-box domain FAM76 (PF16046, IPR032017): FAM76 protein
28	FKBP8	protein found in more fusions	33	0.881	21.272	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
29	FN1	oncoprotein	27	0.459	89.185	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
30	HAUS2	interactor	3	0.667	1.000	DpnII (PF04556, IPR007637): DpnII restriction endonuclease HAUS2 (PF15003, IPR028346): HAUS augmin-like complex subunit 2
31	HECW2	interactor	7	0.533	3.900	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57 RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
32	HNRNPA2B1	oncoprotein	18	0.510	25.529	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
33	HSD17B10	interactor	6	0.800	0.411	adh_short (PF00106, IPR002198): short chain dehydrogenase
34	INSIG2	interactor	15	0.924	0.801	INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
35	IQCB1	interactor	17	0.757	11.425	DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765) IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
36	ITGA4	interactor	23	0.506	47.783	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
37	KIFC3	oncoprotein	7	0.333	157.644	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
38	KRT13	interactor	2	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus Keratin_2_head (PF16208, IPR032444): Keratin type II head
39	KRT15	interactor	4	0.667	2.552	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
40	MAPRE3	interactor	2	1.000	0	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EB1 (PF03271, IPR004953): EB1-like C-terminal motif
41	MCM2	oncoprotein	28	0.373	119.729	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
42	MED4	interactor	8	0.321	20.677	Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
43	MID1	oncoprotein	16	0.857	5.625	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain SPRY (PF00622, IPR003877, SM00449): SPRY domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
44	MRPS9	interactor	6	0.733	1.933	Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
45	MYC	oncoprotein	26	0.583	61.160	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
46	NOTCH2	suppressor	1	0	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
47	PARK2	suppressor	47	0.660	200.818	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
48	PASK	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain PAS_8 (PF13188, IPR000014): PAS domain PAS_9 (PF13426, IPR000014): PAS domain
49	PCK1	interactor	16	0.767	9.314	PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
50	PEX19	interactor	4	1.000	0	Pex19 (PF04614, IPR006708): Pex19 protein family Rod-binding (PF10135, IPR019301): Rod binding protein
51	PGK1	interactor	9	0.694	1.988	PGK (PF00162, IPR001576): Phosphoglycerate kinase
52	PLK1	suppressor	16	0.825	6.376	Pkinase (PF00069, IPR000719): Protein kinase domain POLO_box (PF00659, IPR000959): POLO box duplicated region
53	POMP	interactor	24	0.763	23.941	UMP1 (PF05348, IPR008012): Proteasome maturation factor UMP1
54	PPP4R3A	interactor	6	0.333	7.983	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1 WH1 (PF00568, IPR000697, SM00461): WH1 domain DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
55	PSEN1	oncoprotein	6	0.700	3.567	Presenilin (PF01080, IPR001108): Presenilin LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
56	PSMA1	interactor	66	0.494	406.714	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
57	PSMA2	interactor	64	0.550	245.855	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
58	PSMA3	interactor	63	0.548	239.614	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
59	PSMA4	interactor	55	0.624	121.112	Proteasome (PF00227, IPR001353): Proteasome subunit U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34 Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
60	PSMA5	oncoprotein	66	0.482	838.892	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
61	PSMA6	interactor	64	0.527	281.710	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
62	PSMA7	protein found in more fusions	62	0.574	166.793	Proteasome (PF00227, IPR001353): Proteasome subunit Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
63	PSMA8	interactor	32	0.929	4.909	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature Myb_DNA-bind_5 (PF13873, IPR028002): Myb/SANT-like DNA-binding domain
64	PSMB10	interactor	16	0.917	0.901	Proteasome (PF00227, IPR001353): Proteasome subunit Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
65	PSMB2	interactor	57	0.590	216.278	Proteasome (PF00227, IPR001353): Proteasome subunit
66	PSMB3	protein found in more fusions	66	0.496	348.022	Proteasome (PF00227, IPR001353): Proteasome subunit
67	PSMB4	interactor	59	0.576	182.732	Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Proteasome (PF00227, IPR001353): Proteasome subunit
68	PSMB5	interactor	57	0.603	129.113	Proteasome (PF00227, IPR001353): Proteasome subunit
69	PSMB6	interactor	53	0.668	77.733	DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502) Proteasome (PF00227, IPR001353): Proteasome subunit
70	PSMB7	protein found in more fusions	53	0.689	82.718	Proteasome (PF00227, IPR001353): Proteasome subunit Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
71	PSMB8	interactor	43	0.825	32.378	Proteasome (PF00227, IPR001353): Proteasome subunit
72	PSMB9	interactor	43	0.825	18.698	Proteasome (PF00227, IPR001353): Proteasome subunit
73	PSMC1	interactor	48	0.776	45.396	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) DivIC (PF04977, IPR007060): Septum formation initiator DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815) Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
74	PSMC2	interactor	52	0.749	39.696	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
75	PSMC3	interactor	49	0.749	98.550	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713) JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
76	PSMC4	interactor	47	0.791	60.443	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) NTPase_1 (PF03266, IPR004948): NTPase CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_16 (PF13191): AAA ATPase domain
77	PSMC5	protein found in more fusions	51	0.749	66.103	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Laminin_II (PF06009, IPR010307): Laminin Domain II RILP (PF11461, IPR021563): Rab interacting lysosomal protein AAA_16 (PF13191): AAA ATPase domain
78	PSMC6	interactor	47	0.768	77.786	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily) TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
79	PSMD1	interactor	48	0.770	63.941	PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin) PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat HEAT_2 (PF13646): HEAT repeats
80	PSMD11	interactor	47	0.763	49.357	DUF247 (PF03140, IPR004158): Plant protein of unknown function PCI (PF01399, IPR000717, SM00088): PCI domain AAA_16 (PF13191): AAA ATPase domain TPR_12 (PF13424): Tetratricopeptide repeat
81	PSMD12	interactor	46	0.840	18.121	Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain PCI (PF01399, IPR000717, SM00088): PCI domain
82	PSMD13	interactor	44	0.820	32.019	Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase PCI (PF01399, IPR000717, SM00088): PCI domain
83	PSMD14	interactor	49	0.778	32.728	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
84	PSMD2	oncoprotein	52	0.692	66.079	PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat THAP (PF05485, IPR006612, SM00980): THAP domain HEAT_2 (PF13646): HEAT repeats
85	PSMD3	interactor	50	0.701	77.417	Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat PCI (PF01399, IPR000717, SM00088): PCI domain Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
86	PSMD4	interactor	43	0.872	14.308	UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
87	PSMD5	interactor	39	0.887	11.514	Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
88	PSMD6	interactor	47	0.782	45.953	RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7 PCI (PF01399, IPR000717, SM00088): PCI domain
89	PSMD7	interactor	46	0.799	51.485	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function Auts2 (PF15336): Autism susceptibility gene 2 protein Coilin_N (PF15862, IPR031722): Coilin N-terminus
90	PSMD8	interactor	42	0.908	6.954	CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
91	PSME1	interactor	30	0.833	8.675	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
92	PSME2	interactor	31	0.795	15.006	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
93	PSME3	protein found in more fusions	32	0.710	37.497	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
94	PSME4	interactor	18	0.876	1.894	Filament (PF00038, IPR001664): Intermediate filament protein HEAT (PF02985, IPR000357): HEAT repeat DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437) BLM10_mid (PF16507, IPR032430): Proteasome-substrate-size regulator, mid region
95	PSMG3	interactor	12	0.909	0.446	PAC3 (PF10178, IPR018788): Proteasome assembly chaperone 3
96	PYCRL	interactor	8	1.000	0	F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger P5CR_dimer (PF14748, IPR029036): Pyrroline-5-carboxylate reductase dimerisation
97	RAD23A	oncoprotein	41	0.809	74.394	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
98	RBM8A	interactor	3	1.000	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
99	RIOK3	interactor	3	1.000	0	RIO1 (PF01163, IPR018934): RIO1 family
100	RPL10A	interactor	11	0.836	2.285	Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
101	RPL24	interactor	10	0.778	7.077	MAS20 (PF02064, IPR002056): MAS20 protein import receptor Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
102	RPL5	suppressor	14	0.615	19.274	Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
103	RPL7A	interactor	12	0.712	7.401	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
104	RPP30	interactor	3	0.667	0.095	RNase_P_p30 (PF01876, IPR002738): RNase P subunit p30
105	RPP38	interactor	8	1.000	0	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
106	RPS15A	interactor	17	0.507	30.501	Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
107	RPS23	interactor	8	1.000	0	Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
108	SEC13	interactor	5	0.500	1.700	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
109	SERPINB2	interactor	1	0	0	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
110	SERPINE1	interactor	3	1.000	0	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
111	SF3A1	interactor	8	0.786	4.233	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
112	SHFM1	interactor	33	0.754	16.109	CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
113	SLX1B	interactor	15	0.943	0.767	GIY-YIG (PF01541, IPR000305, SM00465): GIY-YIG catalytic domain FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
114	SNX3	interactor	4	0.667	2.000	PX (PF00787, IPR001683, SM00312): PX domain
115	SRSF2	oncoprotein	10	0.556	6.966	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP2 (PF01254, IPR000678): Nuclear transition protein 2 Transformer (PF06495, IPR010519): Fruit fly transformer protein Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
116	SUGT1	interactor	7	0.571	1.893	CheC (PF04509, IPR007597): CheC-like family CS (PF04969, IPR007052): CS domain SGS (PF05002, IPR007699): SGS domain TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
117	SYVN1	protein found in more fusions	17	0.975	0.300	Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
118	THBS3	oncoprotein	2	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain Laminin_G_2 (PF02210, IPR001791): Laminin G domain TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EGF_3 (PF12947, IPR024731): EGF domain
119	TRAF1	oncoprotein	5	0.667	1.567	HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA SlyX (PF04102, IPR007236): SlyX TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
120	TRIM27	oncoprotein	10	0.417	138.264	IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
121	UBC	protein found in more fusions	53	0.440	754.504	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
122	UBE2A	interactor	8	0.524	8.288	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
123	UBE2V1	interactor	8	0.393	9.201	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
124	UBE4B	suppressor	5	0.500	2.500	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core U-box (PF04564, IPR003613, SM00504): U-box domain DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
125	UCHL5	oncoprotein	39	0.919	23.768	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
126	UFM1	interactor	3	0.667	1.000	Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
127	UNK	interactor	4	0.500	2.000	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
128	VCAM1	interactor	23	0.522	57.621	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
129	VHL	suppressor	16	0.438	28.410	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): VHL beta domain VHL_C (PF17211): VHL box domain

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