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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DCBLD2, ALCAM (from a repository: Sat Jul 27 18:12:25 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins7 (41.18 %)
The number (and %) of the tumor suppressors1 (5.88 %)
Total number of binary PPIs (saturation %)33 (24.26 %)
The number (and %) of affected PPIs16 (48.48 %)
The number of possible different fusions4
PPI diameter4
PPI radius2
The average degree of PPI3.294
Assortativity coefficient-0.2445
The network average Clustering coefficient0.285
The number (and %) of a zero Clustering coefficients7 (41.18 %)
The number (and %) of a zero Betweenness Centrality6 (35.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ALCAM,DCBLD2 All fusions
Proteins found in more fusions EGFR (see 2 fusions); LGALS3 (see 2 fusions); TRAF6 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ALCAMparental protein70.19068.333C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4366 (PF14283, IPR025376): Domain of unknown function (DUF4366)
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
2 DCBLD2parental protein90.083123.367CUB (PF00431, IPR000859, SM00042): CUB domain
LCCL (PF03815, IPR004043, SM00603): LCCL domain
Syndecan (PF01034, IPR027789): Syndecan domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
3 ART3interactor100ART (PF01129, IPR000768): NAD:arginine ADP-ribosyltransferase
4 CD6oncoprotein100SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
TMEM154 (PF15102, IPR028064): TMEM154 protein family
5 EGFRoncoprotein70.40056.233Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
6 ELAVL1oncoprotein303.833RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
7 HLA-DRAinteractor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
8 ITM2Binteractor100BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SpoVG (PF04026, IPR007170): SpoVG
9 LGALS3oncoprotein50.6673.367Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
10 LGALS8interactor30.6672.700Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
11 LGALS9interactor30.6672.700Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
12 NAAAinteractor21.0000CBAH (PF02275, IPR003199): Linear amide C-N hydrolases, choloylglycine hydrolase family
NAAA-beta (PF15508, IPR029130): beta subunit of N-acylethanolamine-hydrolyzing acid amidase
13 NTRK1oncoprotein50.16721.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
14 PTPRKsuppressor60.33339.300fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
15 SEMA4Boncoprotein100PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
16 SIAEinteractor30.6673.333SASA (PF03629, IPR005181): Carbohydrate esterase, sialic acid-specific acetylesterase
17 TRAF6protein found in more fusions303.833SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)

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