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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EXTL3, SERPING1 (from a repository: Wed Jul 17 23:54:31 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins6 (24.00 %)
The number (and %) of the tumor suppressors2 (8.00 %)
Total number of binary PPIs (saturation %)34 (11.33 %)
The number (and %) of affected PPIs23 (67.65 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI2.320
Assortativity coefficient-0.4333
The network average Clustering coefficient0.296
The number (and %) of a zero Clustering coefficients15 (60.00 %)
The number (and %) of a zero Betweenness Centrality19 (76.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EXTL3,SERPING1 All fusions
Proteins found in more fusions SRPK2 (see 1 fusions); SERPING1/ALB (see 1 fusions); PLEKHA5 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EXTL3parental protein100.022288.000Exostosin (PF03016, IPR004263): Exostosin family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Glyco_transf_64 (PF09258, IPR015338): Glycosyl transferase family 64 domain
2 SERPING1parental protein130.038394.000PT (PF04886, IPR006970): PT repeat
Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
3 ALBprotein found in more fusions21.0000Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 BAG6interactor200DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
5 C1Rinteractor31.0000CUB (PF00431, IPR000859, SM00042): CUB domain
DUF842 (PF05811, IPR008560): Eukaryotic protein of unknown function (DUF842)
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
6 C1Sinteractor21.0000CUB (PF00431, IPR000859, SM00042): CUB domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
7 ELANEinteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
8 ENO1oncoprotein20145.000Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
9 F2interactor21.0000Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Kringle (PF00051, IPR000001): Kringle domain
Thrombin_light (PF09396, IPR018992): Thrombin light chain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
Antifungal_pept (PF11410, IPR024206): Antifungal peptide
10 GLRA2interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
11 LPAR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
12 MASP1interactor21.0000CUB (PF00431, IPR000859, SM00042): CUB domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
13 MASP2interactor21.0000CUB (PF00431, IPR000859, SM00042): CUB domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
14 NR4A1suppressor100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
15 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
16 PLEKHA5protein found in more fusions30115.000PH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
17 SCARA3interactor30.333139.000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Filament (PF00038, IPR001664): Intermediate filament protein
Flagellin_C (PF00700, IPR001029): Bacterial flagellin C-terminal helical region
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
18 SELEoncoprotein100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
19 SELPinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
20 SLC39A4suppressor100Zip (PF02535, IPR003689): ZIP Zinc transporter
Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
21 SRPK2oncoprotein30121.000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
22 SYNE4interactor100KASH (PF10541, IPR012315): Nuclear envelope localisation domain
23 WBP1interactor100WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
24 XIAPinteractor31.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
25 ZACNinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region

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