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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EXTL3, HOXB-AS3 (from a repository: Tue Sep 17 13:40:37 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins2 (16.67 %)
The number (and %) of the tumor suppressors1 (8.33 %)
Total number of binary PPIs (saturation %)13 (19.70 %)
The number (and %) of affected PPIs10 (76.92 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI1.833
Assortativity coefficient-0.5164
The network average Clustering coefficient0.169
The number (and %) of a zero Clustering coefficients9 (75.00 %)
The number (and %) of a zero Betweenness Centrality11 (91.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HOXB-AS3,EXTL3 All fusions
Proteins found in more fusions PLEKHA5 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HOXB-AS3interactor000NA
2 EXTL3parental protein100.02288.000Exostosin (PF03016, IPR004263): Exostosin family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Glyco_transf_64 (PF09258, IPR015338): Glycosyl transferase family 64 domain
3 GLRA2interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
4 LPAR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
6 PLEKHA5protein found in more fusions200PH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
7 SCARA3interactor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Filament (PF00038, IPR001664): Intermediate filament protein
Flagellin_C (PF00700, IPR001029): Bacterial flagellin C-terminal helical region
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
8 SLC39A4suppressor100Zip (PF02535, IPR003689): ZIP Zinc transporter
Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
9 SYNE4interactor100KASH (PF10541, IPR012315): Nuclear envelope localisation domain
10 WBP1interactor100WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
11 XIAPinteractor31.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
12 ZACNinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region

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