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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ETFB, ATP6V0A4 (from a repository: Sat Aug 10 02:16:41 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins6 (24.00 %)
The number (and %) of the tumor suppressors1 (4.00 %)
Total number of binary PPIs (saturation %)59 (19.67 %)
The number (and %) of affected PPIs23 (38.98 %)
The number of possible different fusions6
PPI diameter4
PPI radius2
The average degree of PPI4.000
Assortativity coefficient-0.3190
The network average Clustering coefficient0.551
The number (and %) of a zero Clustering coefficients6 (24.00 %)
The number (and %) of a zero Betweenness Centrality14 (56.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ATP6V0A4,ETFB All fusions
Proteins found in more fusions APP (see 5 fusions); CUL7 (see 2 fusions); PFKM (see 1 fusions); STAU1 (see 2 fusions); IVD (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ATP6V0A4parental protein100V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
2 ETFBparental protein220.113364.167ETF (PF01012, IPR014730, SM00893): Electron transfer flavoprotein domain
3 ADRB2interactor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 APPprotein found in more fusions70.4007.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATL3interactor30.6671.500GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
6 ATP6AP2interactor200Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
7 CAPGsuppressor100Gelsolin (PF00626, IPR007123): Gelsolin repeat
8 CUL7protein found in more fusions60.6002.500ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
9 DLDinteractor21.0000Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
10 DYNLT1interactor30.6670.500Tctex-1 (PF03645, IPR005334): Tctex-1 family
11 ETFAinteractor90.25036.500ETF (PF01012, IPR014730, SM00893): Electron transfer flavoprotein domain
ETF_alpha (PF00766, IPR014731): Electron transfer flavoprotein FAD-binding domain
12 ETFRF1interactor31.0000Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
13 GOLT1Binteractor100Got1 (PF04178, IPR007305): Got1/Sft2-like family
14 GPX4interactor21.0000GSHPx (PF00255, IPR000889): Glutathione peroxidase
15 GRHPRinteractor21.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
16 HADHinteractor40.6672.0003HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
17 IRF2BPLinteractor21.0000Calpain_inhib (PF00748, IPR001259): Calpain inhibitor
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
18 IVDprotein found in more fusions31.0000Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
19 LRPPRCinteractor50.6006.500DED (PF01335, IPR001875, SM00031): Death effector domain
MA3 (PF02847, IPR003891, SM00544): MA3 domain
PPR (PF01535, IPR002885): PPR repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
TPR_19 (PF14559): Tetratricopeptide repeat
PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR
20 NTRK1oncoprotein120.218119.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
21 PFKMprotein found in more fusions3046.000PFK (PF00365, IPR000023): Phosphofructokinase
22 PITPNBinteractor21.0000IP_trans (PF02121, IPR001666): Phosphatidylinositol transfer protein
23 RABGGTAinteractor100PPTA (PF01239, IPR002088): Protein prenyltransferase alpha subunit repeat
RabGGT_insert (PF07711, IPR009087): Rab geranylgeranyl transferase alpha-subunit, insert domain
LRR_9 (PF14580): Leucine-rich repeat
24 STAU1protein found in more fusions70.6006.333dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
25 XPO1interactor31.0000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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